Motif ID: GMEB2

Z-value: 0.943


Transcription factors associated with GMEB2:

Gene SymbolEntrez IDGene Name
GMEB2 ENSG00000101216.6 GMEB2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GMEB2hg19_v2_chr20_-_62258394_622584640.038.7e-01Click!


Activity profile for motif GMEB2.

activity profile for motif GMEB2


Sorted Z-values histogram for motif GMEB2

Sorted Z-values for motif GMEB2



Network of associatons between targets according to the STRING database.



First level regulatory network of GMEB2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_66797627 0.916 ENST00000565627.1
ENST00000564179.1
 ZWILCH

zwilch kinetochore protein

chr15_+_66797455 0.838 ENST00000446801.2
 ZWILCH
zwilch kinetochore protein
chr1_+_92495528 0.830 ENST00000370383.4
 EPHX4
epoxide hydrolase 4
chr7_+_120590803 0.776 ENST00000315870.5
ENST00000339121.5
ENST00000445699.1
 ING3


inhibitor of growth family, member 3


chr4_-_74964904 0.766 ENST00000508487.2
 CXCL2
chemokine (C-X-C motif) ligand 2
chr5_+_162887556 0.707 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
 HMMR


hyaluronan-mediated motility receptor (RHAMM)


chr18_+_2571510 0.678 ENST00000261597.4
ENST00000575515.1
 NDC80

NDC80 kinetochore complex component

chr12_+_122064673 0.676 ENST00000537188.1
 ORAI1
ORAI calcium release-activated calcium modulator 1
chr5_-_74162605 0.648 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
 FAM169A


family with sequence similarity 169, member A


chr7_+_100472717 0.646 ENST00000457580.2
ENST00000388793.4
ENST00000432932.1
ENST00000347433.4
 SRRT



serrate RNA effector molecule homolog (Arabidopsis)



chr11_-_65667997 0.637 ENST00000312562.2
ENST00000534222.1
 FOSL1

FOS-like antigen 1

chr16_-_46655538 0.618 ENST00000303383.3
 SHCBP1
SHC SH2-domain binding protein 1
chr7_-_45026159 0.610 ENST00000584327.1
ENST00000438705.3
 SNHG15

small nucleolar RNA host gene 15 (non-protein coding)

chr11_-_65667884 0.587 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
 FOSL1


FOS-like antigen 1


chr5_+_149340282 0.585 ENST00000286298.4
 SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr11_+_61583721 0.569 ENST00000257261.6
 FADS2
fatty acid desaturase 2
chr15_+_40453204 0.567 ENST00000287598.6
ENST00000412359.3
 BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr7_-_45026419 0.556 ENST00000578968.1
ENST00000580528.1
 SNHG15

small nucleolar RNA host gene 15 (non-protein coding)

chr2_+_183989083 0.554 ENST00000295119.4
 NUP35
nucleoporin 35kDa
chr2_+_183989157 0.552 ENST00000541912.1
 NUP35
nucleoporin 35kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.5 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 1.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 1.3 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 1.1 GO:0006999 nuclear pore organization(GO:0006999)
0.1 1.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 1.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.9 GO:0045144 meiotic sister chromatid segregation(GO:0045144)
0.1 0.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 0.8 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.8 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.8 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.8 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.8 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 0.7 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.7 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.7 GO:0010032 meiotic chromosome condensation(GO:0010032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0030684 preribosome(GO:0030684)
0.4 1.8 GO:1990423 RZZ complex(GO:1990423)
0.1 1.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 1.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.3 GO:0042555 MCM complex(GO:0042555)
0.1 1.0 GO:0070761 PCAF complex(GO:0000125) pre-snoRNP complex(GO:0070761)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.8 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 0.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.7 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.7 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 0.7 GO:0000796 condensin complex(GO:0000796)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 1.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.8 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.7 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 0.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.6 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.2 0.6 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.3 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 2.2 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.8 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.1 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.9 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.8 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.7 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway