Motif ID: GRHL1

Z-value: 0.886


Transcription factors associated with GRHL1:

Gene SymbolEntrez IDGene Name
GRHL1 ENSG00000134317.13 GRHL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_10091864,
hg19_v2_chr2_+_10091783_10091811		0.711.1e-04Click!


Activity profile for motif GRHL1.

activity profile for motif GRHL1


Sorted Z-values histogram for motif GRHL1

Sorted Z-values for motif GRHL1



Network of associatons between targets according to the STRING database.



First level regulatory network of GRHL1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_20806440 5.497 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr1_-_153113927 4.328 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr7_-_102283238 2.137 ENST00000340457.8
 UPK3BL
uroplakin 3B-like
chr7_-_102184083 2.089 ENST00000379357.5
 POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr1_-_24469602 1.820 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr11_+_706595 1.604 ENST00000531348.1
ENST00000530636.1
 EPS8L2

EPS8-like 2

chr9_+_5450503 1.571 ENST00000381573.4
ENST00000381577.3
 CD274

CD274 molecule

chr14_-_80677815 1.548 ENST00000557125.1
ENST00000555750.1
 DIO2

deiodinase, iodothyronine, type II

chr20_-_54967187 1.529 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A













chr7_+_76139925 1.445 ENST00000394849.1
 UPK3B
uroplakin 3B
chr2_+_113816215 1.410 ENST00000346807.3
 IL36RN
interleukin 36 receptor antagonist
chr7_+_76139833 1.342 ENST00000257632.5
 UPK3B
uroplakin 3B
chr2_-_85641162 1.336 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG


capping protein (actin filament), gelsolin-like


chr3_+_101568349 1.334 ENST00000326151.5
ENST00000326172.5
 NFKBIZ

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

chr7_-_80551671 1.324 ENST00000419255.2
ENST00000544525.1
 SEMA3C

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

chr11_-_67442196 1.266 ENST00000525827.1
 ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr10_+_105036909 1.188 ENST00000369849.4
 INA
internexin neuronal intermediate filament protein, alpha
chr1_+_155023757 1.185 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
 ADAM15










ADAM metallopeptidase domain 15










chr1_-_201368707 1.175 ENST00000391967.2
 LAD1
ladinin 1
chr14_-_80677613 1.143 ENST00000556811.1
 DIO2
deiodinase, iodothyronine, type II
chr1_-_201368653 1.120 ENST00000367313.3
 LAD1
ladinin 1
chr1_+_35247859 1.060 ENST00000373362.3
 GJB3
gap junction protein, beta 3, 31kDa
chr2_+_95940220 1.042 ENST00000542147.1
 PROM2
prominin 2
chr11_-_67442079 1.005 ENST00000349015.3
 ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr8_-_130799134 0.991 ENST00000276708.4
 GSDMC
gasdermin C
chr2_+_95940186 0.960 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
 PROM2


prominin 2


chr20_-_61002584 0.942 ENST00000252998.1
 RBBP8NL
RBBP8 N-terminal like
chr19_+_19496728 0.937 ENST00000537887.1
ENST00000417582.2
 GATAD2A

GATA zinc finger domain containing 2A

chr17_+_9728828 0.917 ENST00000262441.5
 GLP2R
glucagon-like peptide 2 receptor
chr6_+_32121218 0.907 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
 PPT2


palmitoyl-protein thioesterase 2


chr12_+_123874589 0.811 ENST00000437502.1
 SETD8
SET domain containing (lysine methyltransferase) 8
chr1_-_28384598 0.811 ENST00000373864.1
 EYA3
eyes absent homolog 3 (Drosophila)
chr19_-_15590306 0.773 ENST00000292609.4
 PGLYRP2
peptidoglycan recognition protein 2
chr11_+_119039414 0.741 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
 NLRX1



NLR family member X1



chr7_+_76139741 0.739 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
 UPK3B



uroplakin 3B



chr19_-_17356697 0.671 ENST00000291442.3
 NR2F6
nuclear receptor subfamily 2, group F, member 6
chr9_+_77703414 0.642 ENST00000346234.6
 OSTF1
osteoclast stimulating factor 1
chr5_-_132299313 0.632 ENST00000265343.5
 AFF4
AF4/FMR2 family, member 4
chr18_-_35145728 0.627 ENST00000361795.5
ENST00000603232.1
 CELF4

CUGBP, Elav-like family member 4

chr3_-_49142504 0.571 ENST00000306125.6
ENST00000420147.2
 QARS

glutaminyl-tRNA synthetase

chr20_-_25320367 0.506 ENST00000450393.1
ENST00000491682.1
 ABHD12

abhydrolase domain containing 12

chr19_+_10736183 0.480 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
 SLC44A2


solute carrier family 44 (choline transporter), member 2


chr3_-_49142178 0.474 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
 QARS


glutaminyl-tRNA synthetase


chr18_+_9475001 0.472 ENST00000019317.4
 RALBP1
ralA binding protein 1
chr9_-_77703115 0.422 ENST00000361092.4
ENST00000376808.4
 NMRK1

nicotinamide riboside kinase 1

chr19_+_19496624 0.406 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A


GATA zinc finger domain containing 2A


chr2_-_209118974 0.379 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
 IDH1


isocitrate dehydrogenase 1 (NADP+), soluble


chr6_-_31107127 0.377 ENST00000259845.4
 PSORS1C2
psoriasis susceptibility 1 candidate 2
chr11_-_69590101 0.368 ENST00000168712.1
 FGF4
fibroblast growth factor 4
chr1_-_51425772 0.353 ENST00000371778.4
 FAF1
Fas (TNFRSF6) associated factor 1
chr7_-_138794081 0.325 ENST00000464606.1
 ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr12_+_18414446 0.300 ENST00000433979.1
 PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr19_+_58038683 0.296 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
 ZNF549



zinc finger protein 549



chr18_-_35145981 0.286 ENST00000420428.2
ENST00000412753.1
 CELF4

CUGBP, Elav-like family member 4

chr14_-_23540826 0.271 ENST00000357481.2
 ACIN1
apoptotic chromatin condensation inducer 1
chr1_+_44440575 0.233 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
 ATP6V0B


ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b


chr5_-_132299290 0.230 ENST00000378595.3
 AFF4
AF4/FMR2 family, member 4
chr4_+_156588249 0.225 ENST00000393832.3
 GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_-_99850243 0.192 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
 EIF4E



eukaryotic translation initiation factor 4E



chr18_-_35145689 0.188 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
 CELF4


CUGBP, Elav-like family member 4


chr5_+_134303591 0.165 ENST00000282611.6
 CATSPER3
cation channel, sperm associated 3
chr18_-_35145593 0.121 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
 CELF4


CUGBP, Elav-like family member 4


chr1_+_206643806 0.111 ENST00000537984.1
 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chrX_+_146993449 0.099 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
 FMR1


fragile X mental retardation 1


chr6_-_43027105 0.088 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
 MRPL2



mitochondrial ribosomal protein L2



chr1_-_16539094 0.083 ENST00000270747.3
 ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_-_234667504 0.069 ENST00000421207.1
ENST00000435574.1
 RP5-855F14.1

RP5-855F14.1

chr1_-_36863481 0.055 ENST00000315732.2
 LSM10
LSM10, U7 small nuclear RNA associated
chr19_-_35981358 0.036 ENST00000484218.2
ENST00000338897.3
 KRTDAP

keratinocyte differentiation-associated protein

chr9_+_71736177 0.030 ENST00000606364.1
ENST00000453658.2
 TJP2

tight junction protein 2

chr9_+_130565487 0.016 ENST00000373225.3
ENST00000431857.1
 FPGS

folylpolyglutamate synthase

chr8_+_27950619 0.009 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
 ELP3




elongator acetyltransferase complex subunit 3





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.5 2.0 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.3 1.0 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.3 0.8 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.2 1.6 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 1.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 1.4 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.2 2.7 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.5 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 1.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.9 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 2.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 5.5 GO:0051602 response to electrical stimulus(GO:0051602)
0.1 1.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.7 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 1.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 4.3 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.5 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.0 0.4 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:1900453 negative regulation of long term synaptic depression(GO:1900453) regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 1.8 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 1.3 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.4 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0044393 microspike(GO:0044393)
0.4 1.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 6.6 GO:0005922 connexon complex(GO:0005922)
0.1 1.2 GO:0005883 neurofilament(GO:0005883)
0.1 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 4.3 GO:0001533 cornified envelope(GO:0001533)
0.1 2.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.7 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 1.0 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.3 0.9 GO:0004967 glucagon receptor activity(GO:0004967)
0.3 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 1.4 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 1.2 GO:0042835 BRE binding(GO:0042835)
0.2 0.8 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 2.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 1.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.4 GO:0051990 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.1 0.4 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 2.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 1.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.9 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.5 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane