Motif ID: GSC_GSC2

Z-value: 0.799

Transcription factors associated with GSC_GSC2:

Gene SymbolEntrez IDGene Name
GSC ENSG00000133937.3 GSC
GSC2 ENSG00000063515.2 GSC2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GSC2hg19_v2_chr22_-_19137796_191377960.359.6e-02Click!
GSChg19_v2_chr14_-_95236551_95236576-0.164.5e-01Click!


Activity profile for motif GSC_GSC2.

activity profile for motif GSC_GSC2


Sorted Z-values histogram for motif GSC_GSC2

Sorted Z-values for motif GSC_GSC2



Network of associatons between targets according to the STRING database.



First level regulatory network of GSC_GSC2

PNG image of the network

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Top targets:


Showing 1 to 20 of 194 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_4689649 7.650 ENST00000441199.2
ENST00000416307.2
 VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr4_-_16077741 5.813 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
 PROM1


prominin 1


chr17_-_4689727 5.452 ENST00000328739.5
ENST00000354194.4
 VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr1_+_151682909 3.464 ENST00000326413.3
ENST00000442233.2
 RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr3_+_111393659 2.086 ENST00000477665.1
 PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_+_162351503 1.947 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr15_-_27184664 1.716 ENST00000541819.2
 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr3_-_65583561 1.555 ENST00000460329.2
 MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr3_-_19975665 1.535 ENST00000295824.9
ENST00000389256.4
 EFHB

EF-hand domain family, member B

chr13_+_36050881 1.434 ENST00000537702.1
 NBEA
neurobeachin
chr2_-_175711133 1.242 ENST00000409597.1
ENST00000413882.1
 CHN1

chimerin 1

chr5_+_76114758 1.238 ENST00000514165.1
ENST00000296677.4
 F2RL1

coagulation factor II (thrombin) receptor-like 1

chr22_-_19137796 1.177 ENST00000086933.2
 GSC2
goosecoid homeobox 2
chr5_+_50678921 0.986 ENST00000230658.7
 ISL1
ISL LIM homeobox 1
chr10_+_104178946 0.985 ENST00000432590.1
 FBXL15
F-box and leucine-rich repeat protein 15
chr1_+_244214577 0.969 ENST00000358704.4
 ZBTB18
zinc finger and BTB domain containing 18
chr8_-_133123406 0.907 ENST00000434736.2
 HHLA1
HERV-H LTR-associating 1
chr11_+_61522844 0.806 ENST00000265460.5
 MYRF
myelin regulatory factor
chr17_+_68100989 0.799 ENST00000585558.1
ENST00000392670.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_-_104178857 0.746 ENST00000020673.5
 PSD
pleckstrin and Sec7 domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.8 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0 2.0 GO:0007286 spermatid development(GO:0007286)
0.1 1.3 GO:0071420 cellular response to histamine(GO:0071420)
0.4 1.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.0 1.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 1.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 1.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.3 1.0 GO:0021524 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913)
0.1 0.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.2 0.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.6 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 0.5 GO:0097254 renal tubular secretion(GO:0097254)
0.1 0.5 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.2 GO:0031143 pseudopodium(GO:0031143)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.5 GO:0097470 ribbon synapse(GO:0097470)
0.4 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0030425 dendrite(GO:0030425)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0042805 actinin binding(GO:0042805)
0.1 1.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 1.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.8 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.5 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.5 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.8 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME_OPSINS Genes involved in Opsins
0.0 0.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones