Motif ID: GTF2I

Z-value: 0.976


Transcription factors associated with GTF2I:

Gene SymbolEntrez IDGene Name
GTF2I ENSG00000077809.8 GTF2I

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2Ihg19_v2_chr7_+_74072011_740721190.711.1e-04Click!


Activity profile for motif GTF2I.

activity profile for motif GTF2I


Sorted Z-values histogram for motif GTF2I

Sorted Z-values for motif GTF2I



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_52580920 2.860 ENST00000219746.9
 TOX3
TOX high mobility group box family member 3
chr5_-_121413974 2.675 ENST00000231004.4
 LOX
lysyl oxidase
chr1_-_109656439 2.463 ENST00000369949.4
 C1orf194
chromosome 1 open reading frame 194
chr2_+_85981008 2.257 ENST00000306279.3
 ATOH8
atonal homolog 8 (Drosophila)
chr4_+_30721968 2.215 ENST00000361762.2
 PCDH7
protocadherin 7
chr11_-_46142615 1.997 ENST00000529734.1
ENST00000323180.6
 PHF21A

PHD finger protein 21A

chr18_-_45935663 1.890 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
 ZBTB7C







zinc finger and BTB domain containing 7C







chr5_-_81046904 1.826 ENST00000515395.1
 SSBP2
single-stranded DNA binding protein 2
chr11_-_46142505 1.799 ENST00000524497.1
ENST00000418153.2
 PHF21A

PHD finger protein 21A

chr14_-_54423529 1.657 ENST00000245451.4
ENST00000559087.1
 BMP4

bone morphogenetic protein 4

chr13_-_36705425 1.649 ENST00000255448.4
ENST00000360631.3
ENST00000379892.4
 DCLK1


doublecortin-like kinase 1


chr14_-_21270995 1.645 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
 RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr14_-_61190754 1.631 ENST00000216513.4
 SIX4
SIX homeobox 4
chr19_+_55888186 1.630 ENST00000291934.3
 TMEM190
transmembrane protein 190
chr5_-_81046841 1.597 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
 SSBP2


single-stranded DNA binding protein 2


chr19_+_35629702 1.593 ENST00000351325.4
 FXYD1
FXYD domain containing ion transport regulator 1
chr17_+_72733350 1.577 ENST00000392613.5
ENST00000392612.3
ENST00000392610.1
 RAB37


RAB37, member RAS oncogene family


chr20_+_36531499 1.536 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
 VSTM2L


V-set and transmembrane domain containing 2 like


chr4_-_168155730 1.499 ENST00000502330.1
ENST00000357154.3
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr1_+_183605200 1.454 ENST00000304685.4
 RGL1
ral guanine nucleotide dissociation stimulator-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6 3.3 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.8 3.0 GO:0048389 intermediate mesoderm development(GO:0048389) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098)
0.2 2.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 2.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 2.7 GO:0030449 regulation of complement activation(GO:0030449)
0.1 2.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 2.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.3 2.0 GO:0071233 cellular response to leucine(GO:0071233)
0.1 2.0 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 2.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.5 1.9 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 1.7 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.5 1.6 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.2 1.6 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 1.6 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 1.6 GO:0042073 intraciliary transport(GO:0042073)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.7 GO:0071953 elastic fiber(GO:0071953)
0.2 4.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 3.7 GO:1990391 DNA repair complex(GO:1990391)
0.4 2.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 2.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.1 GO:0036064 ciliary basal body(GO:0036064)
0.3 2.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 2.0 GO:0031902 late endosome membrane(GO:0031902)
0.1 1.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.7 GO:0090544 BAF-type complex(GO:0090544)
0.3 1.6 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 1.6 GO:0000124 SAGA complex(GO:0000124)
0.0 1.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 4.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 4.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 3.8 GO:0070888 E-box binding(GO:0070888)
0.3 3.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 2.9 GO:0034056 estrogen response element binding(GO:0034056)
0.5 2.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 2.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.1 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0019003 GDP binding(GO:0019003)
0.2 1.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.5 1.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 1.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 1.6 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 1.6 GO:0043621 protein self-association(GO:0043621)
0.1 1.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.4 GO:0051400 BH domain binding(GO:0051400)
0.0 1.4 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 1.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.4 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 0.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.0 1.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.1 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.8 REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.7 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation