Motif ID: GUAAACA

Z-value: 1.076


Mature miRNA associated with seed GUAAACA:

NamemiRBase Accession
hsa-miR-30a-5p MIMAT0000087
hsa-miR-30b-5p MIMAT0000420
hsa-miR-30c-5p MIMAT0000244
hsa-miR-30d-5p MIMAT0000245
hsa-miR-30e-5p MIMAT0000692



Activity profile for motif GUAAACA.

activity profile for motif GUAAACA


Sorted Z-values histogram for motif GUAAACA

Sorted Z-values for motif GUAAACA



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAAACA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_86159821 1.813 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr11_-_115375107 1.487 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr8_+_26435359 1.290 ENST00000311151.5
 DPYSL2
dihydropyrimidinase-like 2
chr7_+_100770328 1.163 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr4_-_139163491 1.142 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr7_-_41742697 1.140 ENST00000242208.4
 INHBA
inhibin, beta A
chr10_+_17271266 1.091 ENST00000224237.5
 VIM
vimentin
chr11_-_87908600 1.068 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
 RAB38


RAB38, member RAS oncogene family


chr6_-_30654977 1.032 ENST00000399199.3
 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr7_+_87505544 0.982 ENST00000265728.1
 DBF4
DBF4 homolog (S. cerevisiae)
chr22_+_30792846 0.976 ENST00000312932.9
ENST00000428195.1
 SEC14L2

SEC14-like 2 (S. cerevisiae)

chr7_-_83824169 0.931 ENST00000265362.4
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_+_42634844 0.921 ENST00000315323.3
 FZD2
frizzled family receptor 2
chr7_-_143059845 0.848 ENST00000443739.2
 FAM131B
family with sequence similarity 131, member B
chr5_-_159739532 0.834 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
 CCNJL


cyclin J-like


chr13_-_61989655 0.810 ENST00000409204.4
 PCDH20
protocadherin 20
chr22_+_33197683 0.777 ENST00000266085.6
 TIMP3
TIMP metallopeptidase inhibitor 3
chr5_+_14143728 0.769 ENST00000344204.4
ENST00000537187.1
 TRIO

trio Rho guanine nucleotide exchange factor

chr2_+_95691417 0.767 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr20_+_42295745 0.763 ENST00000396863.4
ENST00000217026.4
 MYBL2

v-myb avian myeloblastosis viral oncogene homolog-like 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.8 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.0 1.8 GO:0048675 axon extension(GO:0048675)
0.4 1.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 1.5 GO:1903232 melanosome assembly(GO:1903232)
0.2 1.3 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 1.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 1.3 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.4 1.2 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.4 1.1 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 1.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.9 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.2 0.8 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.8 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.8 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0 0.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.8 GO:0043525 positive regulation of neuron apoptotic process(GO:0043525)
0.0 0.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.2 0.7 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 1.5 GO:0031905 early endosome lumen(GO:0031905)
0.0 1.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.4 1.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 1.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 0.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 0.8 GO:0031523 Myb complex(GO:0031523)
0.1 0.8 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.8 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.4 1.5 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 1.5 GO:0008301 DNA binding, bending(GO:0008301)
0.4 1.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 1.3 GO:0042169 SH2 domain binding(GO:0042169)
0.2 1.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.4 1.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 0.7 GO:0008431 vitamin E binding(GO:0008431)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.9 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation