Motif ID: GUCAGUU

Z-value: 0.380


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223-3p MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 176 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_68498376 0.997 ENST00000540479.1
ENST00000395465.3
 CALML4

calmodulin-like 4

chr1_-_183622442 0.713 ENST00000308641.4
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr20_-_39317868 0.645 ENST00000373313.2
 MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr13_+_24734844 0.469 ENST00000382108.3
 SPATA13
spermatogenesis associated 13
chr6_-_46138676 0.447 ENST00000371383.2
ENST00000230565.3
 ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chr17_+_53342311 0.431 ENST00000226067.5
 HLF
hepatic leukemia factor
chr17_+_55333876 0.409 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr1_+_244214577 0.387 ENST00000358704.4
 ZBTB18
zinc finger and BTB domain containing 18
chr16_+_19422035 0.343 ENST00000381414.4
ENST00000396229.2
 TMC5

transmembrane channel-like 5

chr8_+_81397876 0.329 ENST00000430430.1
 ZBTB10
zinc finger and BTB domain containing 10
chr11_+_73661364 0.294 ENST00000339764.1
 DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr6_-_79787902 0.287 ENST00000275034.4
 PHIP
pleckstrin homology domain interacting protein
chr1_-_173991434 0.285 ENST00000367696.2
 RC3H1
ring finger and CCCH-type domains 1
chr20_-_4982132 0.274 ENST00000338244.1
ENST00000424750.2
 SLC23A2

solute carrier family 23 (ascorbic acid transporter), member 2

chr17_+_4981535 0.270 ENST00000318833.3
 ZFP3
ZFP3 zinc finger protein
chr1_+_118148556 0.267 ENST00000369448.3
 FAM46C
family with sequence similarity 46, member C
chr2_-_211036051 0.265 ENST00000418791.1
ENST00000452086.1
ENST00000281772.9
 KANSL1L


KAT8 regulatory NSL complex subunit 1-like


chr16_+_22308717 0.258 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
 POLR3E






polymerase (RNA) III (DNA directed) polypeptide E (80kD)






chr7_-_130080977 0.237 ENST00000223208.5
 CEP41
centrosomal protein 41kDa
chr14_+_67999999 0.233 ENST00000329153.5
 PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 0.3 GO:0015993 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.2 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.1 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)

Gene overrepresentation in cellular_component category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)