Motif ID: HAND1

Z-value: 0.459


Transcription factors associated with HAND1:

Gene SymbolEntrez IDGene Name
HAND1 ENSG00000113196.2 HAND1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND1hg19_v2_chr5_-_153857819_153857824-0.096.9e-01Click!


Activity profile for motif HAND1.

activity profile for motif HAND1


Sorted Z-values histogram for motif HAND1

Sorted Z-values for motif HAND1



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_57630873 1.426 ENST00000556732.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr2_+_210444142 0.973 ENST00000360351.4
ENST00000361559.4
 MAP2

microtubule-associated protein 2

chr17_-_43025005 0.628 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
 KIF18B


kinesin family member 18B


chr2_+_228678550 0.621 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr2_-_27718052 0.587 ENST00000264703.3
 FNDC4
fibronectin type III domain containing 4
chr17_+_6347729 0.539 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr17_+_6347761 0.536 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr11_+_118826999 0.506 ENST00000264031.2
 UPK2
uroplakin 2
chr2_+_113816215 0.504 ENST00000346807.3
 IL36RN
interleukin 36 receptor antagonist
chr11_+_124932955 0.478 ENST00000403796.2
 SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr11_+_124932986 0.470 ENST00000407458.1
ENST00000298280.5
 SLC37A2

solute carrier family 37 (glucose-6-phosphate transporter), member 2

chr12_+_49717019 0.460 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
 TROAP







trophinin associated protein







chr11_+_124933191 0.454 ENST00000532000.1
ENST00000308074.4
 SLC37A2

solute carrier family 37 (glucose-6-phosphate transporter), member 2

chr20_-_56285595 0.448 ENST00000395816.3
ENST00000347215.4
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr2_+_204732666 0.442 ENST00000295854.6
ENST00000472206.1
 CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr20_-_56286479 0.440 ENST00000265626.4
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_+_110731062 0.429 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
 LRRN3



leucine rich repeat neuronal 3



chr6_-_112194484 0.402 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
 FYN






FYN oncogene related to SRC, FGR, YES






chr13_-_30881134 0.400 ENST00000380617.3
ENST00000441394.1
 KATNAL1

katanin p60 subunit A-like 1

chrX_+_49832231 0.399 ENST00000376108.3
 CLCN5
chloride channel, voltage-sensitive 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 0.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.6 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.6 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.5 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.5 GO:1903027 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.0 0.5 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.4 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.3 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 0.2 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.1 0.2 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) positive regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000340)
0.0 0.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.6 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.3 GO:0035838 growing cell tip(GO:0035838)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 0.6 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.2 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 0.2 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 0.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL