Motif ID: HES1
Z-value: 0.654
Transcription factors associated with HES1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HES1 | ENSG00000114315.3 | HES1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HES1 | hg19_v2_chr3_+_193853927_193853944 | 0.11 | 6.2e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 218 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.4 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
| 0.1 | 2.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 1.9 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.5 | 1.8 | GO:0046102 | inosine metabolic process(GO:0046102) |
| 0.1 | 1.8 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.6 | 1.7 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.1 | 1.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.5 | 1.6 | GO:0071790 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 0.5 | 1.6 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.2 | 1.6 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.5 | 1.5 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.1 | 1.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 1.5 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.2 | 1.2 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.1 | 1.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 1.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.4 | 1.1 | GO:0051780 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
| 0.1 | 1.1 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.0 | 1.0 | GO:0072698 | protein localization to microtubule cytoskeleton(GO:0072698) |
| 0.1 | 0.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 83 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.3 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.5 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 1.9 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.7 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 1.7 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.5 | 1.6 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.1 | 1.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 1.4 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.1 | 1.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 1.0 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 1.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.2 | 0.9 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 0.8 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.0 | 0.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 153 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 1.8 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.2 | 1.7 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 1.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.5 | 1.6 | GO:0050421 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.1 | 1.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.5 | 1.5 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.2 | 1.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 1.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 1.4 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 1.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 1.2 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 0.4 | 1.1 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
| 0.0 | 1.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 1.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.9 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 0.9 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 0.7 | GO:0004347 | glucose-6-phosphate isomerase activity(GO:0004347) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.8 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.6 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.1 | 1.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.4 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.2 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 1.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.5 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 48 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 2.2 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.7 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 1.7 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.6 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 1.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.2 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 1.1 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.0 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 0.9 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.8 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.7 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.7 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.7 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.6 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.6 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
