Motif ID: HES7_HES5

Z-value: 0.809

Transcription factors associated with HES7_HES5:

Gene SymbolEntrez IDGene Name
HES5 ENSG00000197921.5 HES5
HES7 ENSG00000179111.4 HES7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HES7hg19_v2_chr17_-_8027402_80274320.452.6e-02Click!
HES5hg19_v2_chr1_-_2461684_24617100.135.5e-01Click!


Activity profile for motif HES7_HES5.

activity profile for motif HES7_HES5


Sorted Z-values histogram for motif HES7_HES5

Sorted Z-values for motif HES7_HES5



Network of associatons between targets according to the STRING database.



First level regulatory network of HES7_HES5

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_+_42694732 5.591 ENST00000398646.3
 FAM3B
family with sequence similarity 3, member B
chr13_+_35516390 5.422 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr7_-_73184588 3.131 ENST00000395145.2
 CLDN3
claudin 3
chr1_-_109655377 2.800 ENST00000369948.3
 C1orf194
chromosome 1 open reading frame 194
chr19_+_13106383 1.979 ENST00000397661.2
 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_119066545 1.845 ENST00000415318.1
 CCDC153
coiled-coil domain containing 153
chr17_+_48172639 1.829 ENST00000503176.1
ENST00000503614.1
 PDK2

pyruvate dehydrogenase kinase, isozyme 2

chr9_+_92219919 1.768 ENST00000252506.6
ENST00000375769.1
 GADD45G

growth arrest and DNA-damage-inducible, gamma

chr5_-_54529415 1.682 ENST00000282572.4
 CCNO
cyclin O
chr22_-_31741757 1.659 ENST00000215919.3
 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_220108309 1.611 ENST00000409640.1
 GLB1L
galactosidase, beta 1-like
chr21_-_46330545 1.484 ENST00000320216.6
ENST00000397852.1
 ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

chr19_+_35168633 1.476 ENST00000505365.2
 ZNF302
zinc finger protein 302
chr3_-_125820348 1.337 ENST00000509064.1
ENST00000508835.1
 SLC41A3

solute carrier family 41, member 3

chr17_-_5015129 1.236 ENST00000575898.1
ENST00000416429.2
 ZNF232

zinc finger protein 232

chr11_-_63376013 1.151 ENST00000540943.1
 PLA2G16
phospholipase A2, group XVI
chr1_+_28261492 1.099 ENST00000373894.3
 SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr20_-_2821271 1.052 ENST00000448755.1
ENST00000360652.2
 PCED1A

PC-esterase domain containing 1A

chr11_-_26593649 1.046 ENST00000455601.2
 MUC15
mucin 15, cell surface associated
chr1_+_28261621 1.029 ENST00000549094.1
 SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0030073 insulin secretion(GO:0030073)
0.1 3.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 2.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.8 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 1.8 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 1.7 GO:0006284 base-excision repair(GO:0006284)
0.0 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 1.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 1.0 GO:0010635 regulation of mitochondrial fusion(GO:0010635)
0.3 0.9 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.9 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.8 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 0.7 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.7 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.5 1.8 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 1.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.5 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0035580 specific granule lumen(GO:0035580)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.5 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.4 GO:0001652 granular component(GO:0001652)
0.0 0.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.3 GO:0030849 autosome(GO:0030849)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0005125 cytokine activity(GO:0005125)
0.2 2.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 1.8 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.7 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 1.5 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 1.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 1.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 1.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 1.0 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 1.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 0.9 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.2 0.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.9 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.5 GO:0009008 DNA-methyltransferase activity(GO:0009008)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 2.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.8 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs