Motif ID: HESX1

Z-value: 0.825


Transcription factors associated with HESX1:

Gene SymbolEntrez IDGene Name
HESX1 ENSG00000163666.4 HESX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HESX1hg19_v2_chr3_-_57233966_57234014-0.592.2e-03Click!


Activity profile for motif HESX1.

activity profile for motif HESX1


Sorted Z-values histogram for motif HESX1

Sorted Z-values for motif HESX1



Network of associatons between targets according to the STRING database.



First level regulatory network of HESX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 193 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_161337662 4.328 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr11_+_101918153 3.313 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr6_+_52285131 3.231 ENST00000433625.2
 EFHC1
EF-hand domain (C-terminal) containing 1
chr6_+_116937636 2.672 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr1_-_42921915 2.616 ENST00000372565.3
ENST00000433602.2
 ZMYND12

zinc finger, MYND-type containing 12

chr16_+_19421803 2.408 ENST00000541464.1
 TMC5
transmembrane channel-like 5
chr6_+_52285046 2.251 ENST00000371068.5
 EFHC1
EF-hand domain (C-terminal) containing 1
chr8_-_110656995 2.011 ENST00000276646.9
ENST00000533065.1
 SYBU

syntabulin (syntaxin-interacting)

chr11_+_71791359 2.000 ENST00000419228.1
ENST00000435085.1
ENST00000307198.7
ENST00000538413.1
 LRTOMT



leucine rich transmembrane and O-methyltransferase domain containing



chr16_+_4784273 1.933 ENST00000299320.5
ENST00000586724.1
 C16orf71

chromosome 16 open reading frame 71

chr8_+_120885949 1.738 ENST00000523492.1
ENST00000286234.5
 DEPTOR

DEP domain containing MTOR-interacting protein

chr1_+_15256230 1.684 ENST00000376028.4
ENST00000400798.2
 KAZN

kazrin, periplakin interacting protein

chr2_-_160654745 1.659 ENST00000259053.4
ENST00000429078.2
 CD302

CD302 molecule

chr11_-_5276008 1.342 ENST00000336906.4
 HBG2
hemoglobin, gamma G
chr21_+_33784670 1.310 ENST00000300255.2
 EVA1C
eva-1 homolog C (C. elegans)
chr2_+_230787213 1.308 ENST00000409992.1
 FBXO36
F-box protein 36
chr5_+_149340282 1.282 ENST00000286298.4
 SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr1_+_3614591 1.275 ENST00000378290.4
 TP73
tumor protein p73
chr2_+_230787201 1.270 ENST00000283946.3
 FBXO36
F-box protein 36
chr2_+_85981008 1.262 ENST00000306279.3
 ATOH8
atonal homolog 8 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 2.7 GO:0035082 axoneme assembly(GO:0035082)
0.1 2.0 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 1.8 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 1.8 GO:0070268 cornification(GO:0070268)
0.1 1.7 GO:0045792 negative regulation of cell size(GO:0045792)
0.4 1.5 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.2 1.3 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.1 1.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 1.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.4 1.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.3 1.1 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) phenylpropanoid catabolic process(GO:0046271)
0.1 1.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 1.1 GO:0015671 oxygen transport(GO:0015671)
0.1 1.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 1.0 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 0.9 GO:0061055 myotome development(GO:0061055)
0.1 0.9 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.9 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0072686 mitotic spindle(GO:0072686)
0.9 2.7 GO:0001534 radial spoke(GO:0001534)
0.2 2.0 GO:0097433 dense body(GO:0097433)
0.0 1.7 GO:0030057 desmosome(GO:0030057)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.2 1.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 1.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.1 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.0 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.1 0.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 2.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 2.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.3 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.4 1.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 1.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.9 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 0.7 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.2 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.5 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)