Motif ID: HIC2
Z-value: 1.518
Transcription factors associated with HIC2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HIC2 | ENSG00000169635.5 | HIC2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | 0.35 | 9.6e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 640 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 7.2 | GO:0035878 | nail development(GO:0035878) |
| 1.1 | 6.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.2 | 5.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 4.7 | GO:0090103 | cochlea morphogenesis(GO:0090103) |
| 0.2 | 4.4 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.2 | 4.4 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.5 | 4.3 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 3.9 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.1 | 3.7 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.1 | 3.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.2 | 3.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.4 | 3.3 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.3 | 3.0 | GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) |
| 0.2 | 3.0 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 3.0 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.4 | 2.9 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.0 | 2.9 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.2 | 2.8 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 2.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 240 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 7.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 7.3 | GO:0001726 | ruffle(GO:0001726) |
| 0.4 | 7.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.9 | 6.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 6.1 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 4.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 4.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.5 | 3.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 3.7 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 3.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 3.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 3.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 3.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.3 | 3.0 | GO:0098845 | postsynaptic endosome(GO:0098845) |
| 0.0 | 3.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 2.9 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 2.9 | GO:1904115 | axon cytoplasm(GO:1904115) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 433 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 7.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 7.1 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 6.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 5.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.2 | 4.4 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.2 | 4.0 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.2 | 3.9 | GO:0019841 | retinol binding(GO:0019841) |
| 1.0 | 3.8 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.2 | 3.8 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 3.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 3.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 3.5 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 3.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 3.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 3.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.3 | 3.0 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.2 | 2.9 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 2.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 74 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 11.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 8.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 8.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.8 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.3 | 5.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 4.1 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.7 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 3.6 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 3.0 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 2.9 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.9 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 2.7 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 2.6 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.6 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.1 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.1 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.1 | PID_AURORA_A_PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 143 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 5.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.5 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.3 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 4.0 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 3.8 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 3.2 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.1 | 3.1 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 3.1 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 3.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.8 | REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.1 | 2.7 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 2.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.6 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.5 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.4 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 2.4 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 2.4 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
