Motif ID: HIF1A

Z-value: 0.799


Transcription factors associated with HIF1A:

Gene SymbolEntrez IDGene Name
HIF1A ENSG00000100644.12 HIF1A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIF1Ahg19_v2_chr14_+_62162258_62162269-0.443.3e-02Click!


Activity profile for motif HIF1A.

activity profile for motif HIF1A


Sorted Z-values histogram for motif HIF1A

Sorted Z-values for motif HIF1A



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_19988462 2.144 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr1_+_150254936 1.844 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
 C1orf51


chromosome 1 open reading frame 51


chr4_-_186317034 1.304 ENST00000505916.1
 LRP2BP
LRP2 binding protein
chr12_+_7023735 1.197 ENST00000538763.1
ENST00000544774.1
ENST00000545045.2
 ENO2


enolase 2 (gamma, neuronal)


chr12_+_7023491 1.189 ENST00000541477.1
ENST00000229277.1
 ENO2

enolase 2 (gamma, neuronal)

chrX_+_69509927 1.111 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr8_+_75896731 1.084 ENST00000262207.4
 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr5_+_10441970 1.000 ENST00000274134.4
 ROPN1L
rhophilin associated tail protein 1-like
chr3_-_145878954 0.998 ENST00000282903.5
ENST00000360060.3
 PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr2_-_28113965 0.947 ENST00000302188.3
 RBKS
ribokinase
chr2_+_173420697 0.931 ENST00000282077.3
ENST00000392571.2
ENST00000410055.1
 PDK1


pyruvate dehydrogenase kinase, isozyme 1


chr7_+_48075108 0.794 ENST00000420324.1
ENST00000435376.1
ENST00000430738.1
ENST00000348904.3
ENST00000539619.1
 C7orf57




chromosome 7 open reading frame 57




chr2_-_220083076 0.764 ENST00000295750.4
 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr19_+_5720666 0.740 ENST00000381624.3
ENST00000381614.2
 CATSPERD

catsper channel auxiliary subunit delta

chr10_+_120789223 0.733 ENST00000425699.1
 NANOS1
nanos homolog 1 (Drosophila)
chr2_-_28113217 0.712 ENST00000444339.2
 RBKS
ribokinase
chr11_+_74204395 0.708 ENST00000526036.1
 AP001372.2
AP001372.2
chr14_-_64970494 0.643 ENST00000608382.1
 ZBTB25
zinc finger and BTB domain containing 25
chr19_-_55691614 0.637 ENST00000592470.1
ENST00000354308.3
 SYT5

synaptotagmin V

chr4_-_39529049 0.619 ENST00000501493.2
ENST00000509391.1
ENST00000507089.1
 UGDH


UDP-glucose 6-dehydrogenase



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 1.7 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 1.7 GO:0015886 heme transport(GO:0015886)
0.0 1.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.2 1.2 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 1.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.1 GO:0060325 face morphogenesis(GO:0060325)
0.3 1.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.2 1.0 GO:0035425 autocrine signaling(GO:0035425)
0.0 1.0 GO:0003351 epithelial cilium movement(GO:0003351)
0.3 0.9 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.1 0.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.7 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.7 GO:0048240 sperm capacitation(GO:0048240)
0.2 0.6 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.6 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.2 0.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 0.7 GO:0036128 CatSper complex(GO:0036128)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 1.7 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.0 1.7 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 1.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 1.0 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 1.0 GO:0005521 lamin binding(GO:0005521)
0.2 0.9 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.1 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 0.7 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.2 0.6 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.6 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.5 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.2 0.5 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.5 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint