Motif ID: HMBOX1

Z-value: 0.786


Transcription factors associated with HMBOX1:

Gene SymbolEntrez IDGene Name
HMBOX1 ENSG00000147421.13 HMBOX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMBOX1hg19_v2_chr8_+_28747884_287479380.692.2e-04Click!


Activity profile for motif HMBOX1.

activity profile for motif HMBOX1


Sorted Z-values histogram for motif HMBOX1

Sorted Z-values for motif HMBOX1



Network of associatons between targets according to the STRING database.



First level regulatory network of HMBOX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_25348007 3.102 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr6_+_88117683 2.743 ENST00000369562.4
 C6ORF165
UPF0704 protein C6orf165
chr6_+_112408768 2.477 ENST00000368656.2
ENST00000604268.1
 FAM229B

family with sequence similarity 229, member B

chr9_-_117111222 1.865 ENST00000374079.4
 AKNA
AT-hook transcription factor
chr4_+_9172135 1.796 ENST00000512047.1
 FAM90A26
family with sequence similarity 90, member A26
chr6_-_52668605 1.782 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chr13_+_24144509 1.570 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_+_75536335 1.516 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C



zinc finger, C2HC-type containing 1C



chr14_+_75536280 1.482 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr3_-_57530051 1.383 ENST00000311202.6
ENST00000351747.2
ENST00000495027.1
ENST00000389536.4
 DNAH12



dynein, axonemal, heavy chain 12



chr1_-_169396666 1.359 ENST00000456107.1
ENST00000367805.3
 CCDC181

coiled-coil domain containing 181

chr21_-_46340884 1.334 ENST00000302347.5
ENST00000517819.1
 ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

chr2_+_61293021 1.258 ENST00000402291.1
 KIAA1841
KIAA1841
chr1_-_169396646 1.245 ENST00000367806.3
 CCDC181
coiled-coil domain containing 181
chr1_+_174844645 1.241 ENST00000486220.1
 RABGAP1L
RAB GTPase activating protein 1-like
chr20_+_43211149 1.230 ENST00000372886.1
 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr8_+_67976593 1.174 ENST00000262210.5
ENST00000412460.1
 CSPP1

centrosome and spindle pole associated protein 1

chr4_+_36283213 1.141 ENST00000357504.3
 DTHD1
death domain containing 1
chr2_-_220110187 1.116 ENST00000295759.7
ENST00000392089.2
 GLB1L

galactosidase, beta 1-like

chr2_-_62081148 1.114 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 1.8 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 1.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.4 GO:0001942 hair follicle development(GO:0001942)
0.0 1.2 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.1 GO:0010842 retina layer formation(GO:0010842)
0.0 1.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 1.0 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.9 GO:0001554 luteolysis(GO:0001554)
0.0 0.9 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.9 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 0.7 GO:0035936 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.1 0.7 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.7 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.6 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0002177 manchette(GO:0002177)
0.1 2.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.4 GO:0030286 dynein complex(GO:0030286)
0.2 1.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0034464 BBSome(GO:0034464)
0.2 0.7 GO:0031251 PAN complex(GO:0031251)
0.1 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.4 GO:0097227 sperm annulus(GO:0097227)
0.1 0.3 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.2 2.2 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 1.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.5 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.1 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME_MEIOSIS Genes involved in Meiosis