Motif ID: HMGA1

Z-value: 0.648


Transcription factors associated with HMGA1:

Gene SymbolEntrez IDGene Name
HMGA1 ENSG00000137309.15 HMGA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMGA1hg19_v2_chr6_+_34204642_34204664-0.125.7e-01Click!


Activity profile for motif HMGA1.

activity profile for motif HMGA1


Sorted Z-values histogram for motif HMGA1

Sorted Z-values for motif HMGA1



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_71551652 1.624 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr12_+_20963647 1.267 ENST00000381545.3
 SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr1_-_161337662 1.253 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr12_+_20963632 1.245 ENST00000540853.1
ENST00000261196.2
 SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr4_-_110723194 0.770 ENST00000394635.3
 CFI
complement factor I
chr5_-_13944652 0.768 ENST00000265104.4
 DNAH5
dynein, axonemal, heavy chain 5
chr4_-_110723134 0.756 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr4_+_41540160 0.748 ENST00000503057.1
ENST00000511496.1
 LIMCH1

LIM and calponin homology domains 1

chr9_+_105757590 0.738 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr14_+_96949319 0.674 ENST00000554706.1
 AK7
adenylate kinase 7
chr4_+_36283213 0.625 ENST00000357504.3
 DTHD1
death domain containing 1
chr5_-_147211226 0.613 ENST00000296695.5
 SPINK1
serine peptidase inhibitor, Kazal type 1
chr4_-_110723335 0.581 ENST00000394634.2
 CFI
complement factor I
chr15_+_71228826 0.576 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
 LRRC49




leucine rich repeat containing 49




chr9_-_34397800 0.573 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr15_-_28419569 0.527 ENST00000569772.1
 HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr7_-_138386097 0.526 ENST00000421622.1
 SVOPL
SVOP-like
chr9_-_3469181 0.521 ENST00000366116.2
 AL365202.1
Uncharacterized protein
chr4_+_155484155 0.506 ENST00000509493.1
 FGB
fibrinogen beta chain
chr3_-_74570291 0.469 ENST00000263665.6
 CNTN3
contactin 3 (plasmacytoma associated)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0030449 regulation of complement activation(GO:0030449)
0.0 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 1.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.7 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:1904294 positive regulation of ERAD pathway(GO:1904294)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0036157 outer dynein arm(GO:0036157)
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 2.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.7 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.5 GO:0032183 SUMO binding(GO:0032183)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.3 GO:0016160 amylase activity(GO:0016160)
0.1 0.3 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.1 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.2 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 2.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.5 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion