Motif ID: HMGA1

Z-value: 0.648


Transcription factors associated with HMGA1:

Gene SymbolEntrez IDGene Name
HMGA1 ENSG00000137309.15 HMGA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMGA1hg19_v2_chr6_+_34204642_34204664-0.125.7e-01Click!


Activity profile for motif HMGA1.

activity profile for motif HMGA1


Sorted Z-values histogram for motif HMGA1

Sorted Z-values for motif HMGA1



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_71551652 1.624 ENST00000546561.1
TSPAN8
tetraspanin 8
chr12_+_20963647 1.267 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr1_-_161337662 1.253 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr12_+_20963632 1.245 ENST00000540853.1
ENST00000261196.2
SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr4_-_110723194 0.770 ENST00000394635.3
CFI
complement factor I
chr5_-_13944652 0.768 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr4_-_110723134 0.756 ENST00000510800.1
ENST00000512148.1
CFI

complement factor I

chr4_+_41540160 0.748 ENST00000503057.1
ENST00000511496.1
LIMCH1

LIM and calponin homology domains 1

chr9_+_105757590 0.738 ENST00000374798.3
ENST00000487798.1
CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr14_+_96949319 0.674 ENST00000554706.1
AK7
adenylate kinase 7
chr4_+_36283213 0.625 ENST00000357504.3
DTHD1
death domain containing 1
chr5_-_147211226 0.613 ENST00000296695.5
SPINK1
serine peptidase inhibitor, Kazal type 1
chr4_-_110723335 0.581 ENST00000394634.2
CFI
complement factor I
chr15_+_71228826 0.576 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49




leucine rich repeat containing 49




chr9_-_34397800 0.573 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr15_-_28419569 0.527 ENST00000569772.1
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr7_-_138386097 0.526 ENST00000421622.1
SVOPL
SVOP-like
chr9_-_3469181 0.521 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr4_+_155484155 0.506 ENST00000509493.1
FGB
fibrinogen beta chain
chr3_-_74570291 0.469 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr5_+_140213815 0.464 ENST00000525929.1
ENST00000378125.3
PCDHA7

protocadherin alpha 7

chr7_+_116654935 0.462 ENST00000432298.1
ENST00000422922.1
ST7

suppression of tumorigenicity 7

chr14_-_21270995 0.454 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr4_-_177116772 0.447 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chrX_+_37865804 0.436 ENST00000297875.2
ENST00000357972.5
SYTL5

synaptotagmin-like 5

chr9_-_47314222 0.430 ENST00000420228.1
ENST00000438517.1
ENST00000414020.1
AL953854.2


AL953854.2


chr5_-_147211190 0.424 ENST00000510027.2
SPINK1
serine peptidase inhibitor, Kazal type 1
chr12_-_67197760 0.417 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1



glutamate receptor interacting protein 1



chr3_-_195310802 0.402 ENST00000421243.1
ENST00000453131.1
APOD

apolipoprotein D

chr10_+_115511213 0.389 ENST00000361048.1
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr1_-_160231451 0.386 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr12_+_69742121 0.384 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ


lysozyme


chr13_+_97928395 0.381 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr10_-_28270795 0.372 ENST00000545014.1
ARMC4
armadillo repeat containing 4
chr1_+_12524965 0.371 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr9_+_89563578 0.359 ENST00000415801.1
RP11-276H19.1
RP11-276H19.1
chr17_+_7761013 0.358 ENST00000571846.1
CYB5D1
cytochrome b5 domain containing 1
chr3_+_109128837 0.354 ENST00000497996.1
RP11-702L6.4
RP11-702L6.4
chr3_+_171561127 0.352 ENST00000334567.5
ENST00000450693.1
TMEM212

transmembrane protein 212

chr17_+_7761301 0.351 ENST00000332439.4
ENST00000570446.1
CYB5D1

cytochrome b5 domain containing 1

chr5_+_140207536 0.347 ENST00000529310.1
ENST00000527624.1
PCDHA6

protocadherin alpha 6

chr3_+_14444063 0.347 ENST00000454876.2
ENST00000360861.3
ENST00000416216.2
SLC6A6


solute carrier family 6 (neurotransmitter transporter), member 6


chr1_+_104159999 0.336 ENST00000414303.2
ENST00000423678.1
AMY2A

amylase, alpha 2A (pancreatic)

chr3_-_148939835 0.330 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chr1_-_150738261 0.323 ENST00000448301.2
ENST00000368985.3
CTSS

cathepsin S

chr21_-_43735628 0.322 ENST00000291525.10
ENST00000518498.1
TFF3

trefoil factor 3 (intestinal)

chr2_-_228244013 0.316 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr13_-_49975632 0.312 ENST00000457041.1
ENST00000355854.4
CAB39L

calcium binding protein 39-like

chr13_-_39564993 0.309 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr15_-_40401062 0.308 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF



Bcl2 modifying factor



chr8_-_110620284 0.306 ENST00000529690.1
SYBU
syntabulin (syntaxin-interacting)
chr12_-_91505608 0.306 ENST00000266718.4
LUM
lumican
chr6_-_119031228 0.304 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L


centrosomal protein 85kDa-like


chr6_+_131958436 0.300 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr2_-_209010874 0.298 ENST00000260988.4
CRYGB
crystallin, gamma B
chr1_-_86848760 0.290 ENST00000460698.2
ODF2L
outer dense fiber of sperm tails 2-like
chr5_+_140186647 0.290 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4


protocadherin alpha 4


chr1_+_95975672 0.283 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1

RP11-286B14.1

chr3_-_107596910 0.282 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635












long intergenic non-protein coding RNA 635












chr13_+_96085847 0.276 ENST00000376873.3
CLDN10
claudin 10
chr3_-_167371740 0.274 ENST00000466760.1
ENST00000479765.1
WDR49

WD repeat domain 49

chr3_+_160559931 0.273 ENST00000464260.1
ENST00000295839.9
PPM1L

protein phosphatase, Mg2+/Mn2+ dependent, 1L

chr5_+_68860949 0.272 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr1_+_86934526 0.263 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr5_+_140227048 0.262 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr1_-_157014865 0.254 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr11_+_27076764 0.247 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_-_122102065 0.242 ENST00000479899.1
ENST00000291458.5
ENST00000497726.1
CCDC58


coiled-coil domain containing 58


chr15_+_59730348 0.237 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A



family with sequence similarity 81, member A



chr3_-_120365866 0.236 ENST00000475447.2
HGD
homogentisate 1,2-dioxygenase
chr5_+_140248518 0.236 ENST00000398640.2
PCDHA11
protocadherin alpha 11
chr8_-_18666360 0.235 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chrX_+_36246735 0.234 ENST00000378653.3
CXorf30
chromosome X open reading frame 30
chr4_-_74486347 0.233 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr4_-_22444733 0.232 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr7_+_13141097 0.231 ENST00000411542.1
AC011288.2
AC011288.2
chr12_-_86650045 0.230 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr19_-_1021113 0.230 ENST00000333175.5
ENST00000356663.3
TMEM259

transmembrane protein 259

chr12_+_56661461 0.230 ENST00000546544.1
ENST00000553234.1
COQ10A

coenzyme Q10 homolog A (S. cerevisiae)

chr2_+_1418154 0.227 ENST00000423320.1
ENST00000382198.1
TPO

thyroid peroxidase

chr16_-_18887627 0.225 ENST00000563235.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chrX_-_73072534 0.223 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr18_-_47792851 0.223 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr10_-_69597915 0.221 ENST00000225171.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr7_+_30174426 0.220 ENST00000324453.8
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr7_-_99381798 0.220 ENST00000415003.1
ENST00000354593.2
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr3_+_111717600 0.215 ENST00000273368.4
TAGLN3
transgelin 3
chr5_+_140220769 0.214 ENST00000531613.1
ENST00000378123.3
PCDHA8

protocadherin alpha 8

chr6_-_26056695 0.212 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chrX_+_41548259 0.211 ENST00000378138.5
GPR34
G protein-coupled receptor 34
chr11_+_1940925 0.209 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
TNNT3





troponin T type 3 (skeletal, fast)





chr5_-_61031495 0.206 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2

CTD-2170G1.2

chr12_-_122879969 0.206 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr2_-_217560248 0.206 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr9_+_33629119 0.204 ENST00000331828.4
TRBV21OR9-2
T cell receptor beta variable 21/OR9-2 (pseudogene)
chrX_-_117119243 0.204 ENST00000539496.1
ENST00000469946.1
KLHL13

kelch-like family member 13

chr9_-_21305312 0.201 ENST00000259555.4
IFNA5
interferon, alpha 5
chr1_-_198990166 0.198 ENST00000427439.1
RP11-16L9.3
RP11-16L9.3
chr6_-_76072719 0.198 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr5_-_75008244 0.195 ENST00000510798.1
ENST00000446329.2
POC5

POC5 centriolar protein

chr12_+_41831485 0.194 ENST00000539469.2
ENST00000298919.7
PDZRN4

PDZ domain containing ring finger 4

chr4_-_123542224 0.194 ENST00000264497.3
IL21
interleukin 21
chr1_+_65730385 0.193 ENST00000263441.7
ENST00000395325.3
DNAJC6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr10_+_94594351 0.191 ENST00000371552.4
EXOC6
exocyst complex component 6
chr2_+_109204743 0.189 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr19_+_9361606 0.188 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr10_+_4828815 0.187 ENST00000533295.1
AKR1E2
aldo-keto reductase family 1, member E2
chrX_+_105192423 0.183 ENST00000540278.1
NRK
Nik related kinase
chrX_-_80457385 0.180 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5


high mobility group nucleosome binding domain 5


chrX_-_99987088 0.180 ENST00000372981.1
ENST00000263033.5
SYTL4

synaptotagmin-like 4

chr10_-_123274693 0.176 ENST00000429361.1
FGFR2
fibroblast growth factor receptor 2
chr17_+_61086917 0.175 ENST00000424789.2
ENST00000389520.4
TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr6_-_110011704 0.175 ENST00000448084.2
AK9
adenylate kinase 9
chr11_+_58390132 0.175 ENST00000361987.4
CNTF
ciliary neurotrophic factor
chrX_-_117107680 0.174 ENST00000447671.2
ENST00000262820.3
KLHL13

kelch-like family member 13

chr1_+_202431859 0.173 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr1_+_154401791 0.172 ENST00000476006.1
IL6R
interleukin 6 receptor
chr6_-_139613269 0.172 ENST00000358430.3
TXLNB
taxilin beta
chr6_+_140175987 0.171 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1

RP5-899B16.1

chr11_+_49050504 0.171 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chrX_+_36254051 0.169 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chrX_+_144908928 0.168 ENST00000408967.2
TMEM257
transmembrane protein 257
chr9_-_14308004 0.168 ENST00000493697.1
NFIB
nuclear factor I/B
chr2_-_86333244 0.165 ENST00000263857.6
ENST00000409681.1
POLR1A

polymerase (RNA) I polypeptide A, 194kDa

chr2_+_179184955 0.165 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr7_-_120498357 0.165 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12


tetraspanin 12


chr11_+_30253410 0.165 ENST00000533718.1
FSHB
follicle stimulating hormone, beta polypeptide
chr6_-_49712147 0.164 ENST00000433368.2
ENST00000354620.4
CRISP3

cysteine-rich secretory protein 3

chr12_-_91539918 0.163 ENST00000548218.1
DCN
decorin
chr10_+_96522361 0.163 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr12_-_87232644 0.161 ENST00000549405.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_222436988 0.160 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPHA4



EPH receptor A4



chrX_+_103031421 0.159 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
PLP1


proteolipid protein 1


chr16_+_53241854 0.159 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr13_-_38172863 0.158 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN





periostin, osteoblast specific factor





chr1_-_179112173 0.157 ENST00000408940.3
ENST00000504405.1
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr14_-_20774092 0.156 ENST00000423949.2
ENST00000553828.1
ENST00000258821.3
TTC5


tetratricopeptide repeat domain 5


chr1_-_57431679 0.156 ENST00000371237.4
ENST00000535057.1
ENST00000543257.1
C8B


complement component 8, beta polypeptide


chr14_+_75988768 0.153 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr5_+_140180635 0.153 ENST00000522353.2
ENST00000532566.2
PCDHA3

protocadherin alpha 3

chr1_-_57045228 0.153 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_90338712 0.153 ENST00000265741.3
ENST00000406263.1
CDK14

cyclin-dependent kinase 14

chr6_-_49712123 0.152 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr6_+_153552455 0.151 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr2_+_145780739 0.151 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
TEX41


testis expressed 41 (non-protein coding)


chr4_-_48082192 0.150 ENST00000507351.1
TXK
TXK tyrosine kinase
chr14_+_37641012 0.150 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr18_-_24722995 0.150 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_+_108541608 0.149 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr3_+_138340049 0.146 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr7_-_25268104 0.146 ENST00000222674.2
NPVF
neuropeptide VF precursor
chrX_-_117107542 0.145 ENST00000371878.1
KLHL13
kelch-like family member 13
chr8_+_75262629 0.145 ENST00000434412.2
GDAP1
ganglioside induced differentiation associated protein 1
chr1_+_180601139 0.144 ENST00000367590.4
ENST00000367589.3
XPR1

xenotropic and polytropic retrovirus receptor 1

chr7_-_112727774 0.144 ENST00000297146.3
ENST00000501255.2
GPR85

G protein-coupled receptor 85

chr12_+_54422142 0.143 ENST00000243108.4
HOXC6
homeobox C6
chr8_-_66701319 0.143 ENST00000379419.4
PDE7A
phosphodiesterase 7A
chr14_+_73563735 0.143 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr18_-_53177984 0.143 ENST00000543082.1
TCF4
transcription factor 4
chr10_+_94590910 0.143 ENST00000371547.4
EXOC6
exocyst complex component 6
chr1_+_158325684 0.141 ENST00000368162.2
CD1E
CD1e molecule
chr7_+_123241908 0.141 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15


ankyrin repeat and SOCS box containing 15


chr4_-_89744314 0.140 ENST00000508369.1
FAM13A
family with sequence similarity 13, member A
chr12_-_86650077 0.140 ENST00000552808.2
ENST00000547225.1
MGAT4C

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

chr6_-_87804815 0.140 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr11_-_124180733 0.139 ENST00000357821.2
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr1_-_152086556 0.139 ENST00000368804.1
TCHH
trichohyalin
chr10_-_116444371 0.139 ENST00000533213.2
ENST00000369252.4
ABLIM1

actin binding LIM protein 1

chr3_+_69812701 0.139 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr14_-_90085458 0.138 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3


forkhead box N3


chr2_-_71222466 0.138 ENST00000606025.1
AC007040.11
Uncharacterized protein
chr7_+_116660246 0.137 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
ST7





suppression of tumorigenicity 7





chr3_+_108541545 0.137 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr3_+_173116225 0.136 ENST00000457714.1
NLGN1
neuroligin 1
chr6_+_20534672 0.135 ENST00000274695.4
ENST00000378624.4
CDKAL1

CDK5 regulatory subunit associated protein 1-like 1

chr1_-_179112189 0.134 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr5_-_27038683 0.134 ENST00000511822.1
ENST00000231021.4
CDH9

cadherin 9, type 2 (T1-cadherin)

chr2_-_89545079 0.134 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr11_+_101983176 0.134 ENST00000524575.1
YAP1
Yes-associated protein 1
chr1_+_174844645 0.133 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr6_-_52705641 0.133 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr11_+_71249071 0.133 ENST00000398534.3
KRTAP5-8
keratin associated protein 5-8
chrX_-_19688475 0.133 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr11_-_34535297 0.131 ENST00000532417.1
ELF5
E74-like factor 5 (ets domain transcription factor)
chr2_+_191792376 0.131 ENST00000409428.1
ENST00000409215.1
GLS

glutaminase

chr6_-_161085291 0.130 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr6_+_12717892 0.130 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr6_-_39197226 0.130 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr5_+_135496675 0.130 ENST00000507637.1
SMAD5
SMAD family member 5
chr9_-_28670283 0.130 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_+_33278811 0.129 ENST00000303296.4
ENST00000379016.3
HIPK3

homeodomain interacting protein kinase 3

chr10_-_69597810 0.129 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr1_+_61330931 0.128 ENST00000371191.1
NFIA
nuclear factor I/A
chr14_+_51026743 0.127 ENST00000358385.6
ENST00000357032.3
ENST00000354525.4
ATL1


atlastin GTPase 1


chr5_+_161112754 0.124 ENST00000523217.1
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr8_-_116504448 0.123 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr1_+_204839959 0.122 ENST00000404076.1
NFASC
neurofascin
chr12_-_22063787 0.120 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr4_+_155484103 0.120 ENST00000302068.4
FGB
fibrinogen beta chain
chr12_-_15082050 0.120 ENST00000540097.1
ERP27
endoplasmic reticulum protein 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.2 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.1 0.2 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.1 0.2 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 0.2 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.1 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.1 1.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.2 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.1 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.2 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.2 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:1990523 bone regeneration(GO:1990523)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.2 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.0 GO:0000060 protein import into nucleus, translocation(GO:0000060)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.1 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.1 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0044691 tooth eruption(GO:0044691)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 2.4 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.2 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.0 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.0 0.1 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.0 0.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.0 GO:0019285 amino-acid betaine biosynthetic process(GO:0006578) glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0033088 regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.0 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.7 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.0 GO:0050758 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) cellular response to folic acid(GO:0071231)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.0 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.2 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:1903286 regulation of potassium ion import(GO:1903286) regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.0 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.8 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.3 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.7 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.3 GO:0016160 amylase activity(GO:0016160)
0.1 0.3 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.1 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.2 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.2 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 0.2 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.2 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.0 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.0 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.1 2.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.3 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis