Motif ID: HMGA2

Z-value: 0.472


Transcription factors associated with HMGA2:

Gene SymbolEntrez IDGene Name
HMGA2 ENSG00000149948.9 HMGA2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_66218678-0.744.1e-05Click!


Activity profile for motif HMGA2.

activity profile for motif HMGA2


Sorted Z-values histogram for motif HMGA2

Sorted Z-values for motif HMGA2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_34397800 1.401 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr1_+_196621156 0.906 ENST00000359637.2
 CFH
complement factor H
chr5_+_36608422 0.720 ENST00000381918.3
 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_129691195 0.699 ENST00000368671.3
 CLRN3
clarin 3
chr11_+_73661364 0.660 ENST00000339764.1
 DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr1_+_196621002 0.655 ENST00000367429.4
ENST00000439155.2
 CFH

complement factor H

chr6_-_52705641 0.644 ENST00000370989.2
 GSTA5
glutathione S-transferase alpha 5
chr2_+_120436733 0.598 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
 TMEM177


transmembrane protein 177


chr6_-_32908792 0.530 ENST00000418107.2
 HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_-_216257849 0.482 ENST00000456923.1
 FN1
fibronectin 1
chr17_-_30186328 0.405 ENST00000302362.6
 COPRS
coordinator of PRMT5, differentiation stimulator
chr12_+_113587558 0.400 ENST00000335621.6
 CCDC42B
coiled-coil domain containing 42B
chrX_-_7895479 0.368 ENST00000381042.4
 PNPLA4
patatin-like phospholipase domain containing 4
chrX_-_7895755 0.365 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
 PNPLA4


patatin-like phospholipase domain containing 4


chr19_-_11457162 0.363 ENST00000590482.1
 TMEM205
transmembrane protein 205
chr19_-_11457082 0.354 ENST00000587948.1
 TMEM205
transmembrane protein 205
chr19_-_11456722 0.343 ENST00000354882.5
 TMEM205
transmembrane protein 205
chr20_+_48884002 0.326 ENST00000425497.1
ENST00000445003.1
 RP11-290F20.3

RP11-290F20.3

chr19_-_11456905 0.326 ENST00000588560.1
ENST00000592952.1
 TMEM205

transmembrane protein 205

chr1_+_2487800 0.319 ENST00000355716.4
 TNFRSF14
tumor necrosis factor receptor superfamily, member 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 0.8 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.7 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.7 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.7 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.4 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.2 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.7 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.2 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins