Motif ID: HMX1
Z-value: 0.599
Transcription factors associated with HMX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HMX1 | ENSG00000215612.5 | HMX1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMX1 | hg19_v2_chr4_-_8873531_8873543 | 0.30 | 1.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.4 | 1.1 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487) |
| 0.2 | 2.5 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 0.5 | GO:1902214 | negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214) |
| 0.2 | 2.6 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.1 | 1.0 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 1.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.8 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.1 | 0.3 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.1 | 0.5 | GO:0019470 | 4-hydroxyproline catabolic process(GO:0019470) |
| 0.1 | 0.1 | GO:0016539 | intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) |
| 0.1 | 0.3 | GO:0001983 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 0.1 | 0.2 | GO:1900158 | negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.1 | 0.4 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.1 | 0.3 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.1 | 0.4 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.1 | 0.3 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 0.2 | GO:0015729 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.1 | 0.2 | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process(GO:0042351) |
| 0.1 | 0.4 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.1 | 0.2 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.1 | 0.2 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.1 | 1.4 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.1 | 0.6 | GO:0061525 | hindgut development(GO:0061525) |
| 0.1 | 0.2 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.1 | 0.3 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.1 | 0.2 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.1 | 0.2 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 0.8 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.1 | 1.7 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.1 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 0.1 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
| 0.0 | 0.4 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.0 | 0.3 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.1 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.0 | 0.3 | GO:0033504 | floor plate development(GO:0033504) |
| 0.0 | 1.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.2 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.0 | 0.3 | GO:0035799 | ureter maturation(GO:0035799) |
| 0.0 | 0.1 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 0.0 | 0.6 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.1 | GO:1990418 | response to insulin-like growth factor stimulus(GO:1990418) |
| 0.0 | 0.2 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.0 | 0.1 | GO:0034239 | macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) |
| 0.0 | 0.2 | GO:0032439 | endosome localization(GO:0032439) |
| 0.0 | 0.1 | GO:0090027 | negative regulation of monocyte chemotaxis(GO:0090027) |
| 0.0 | 0.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.4 | GO:1904152 | regulation of retrograde protein transport, ER to cytosol(GO:1904152) |
| 0.0 | 0.1 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.0 | 0.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.0 | 0.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 0.1 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.1 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.0 | 0.2 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.0 | 0.3 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 0.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 0.3 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.0 | 0.2 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.0 | 0.3 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.0 | 0.3 | GO:0000963 | mitochondrial RNA processing(GO:0000963) |
| 0.0 | 0.2 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.0 | 0.0 | GO:0080154 | regulation of fertilization(GO:0080154) |
| 0.0 | 0.5 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.1 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 0.4 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.0 | 0.7 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.1 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.0 | 0.1 | GO:0003418 | growth plate cartilage chondrocyte differentiation(GO:0003418) |
| 0.0 | 0.0 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.0 | 0.0 | GO:0002025 | vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) |
| 0.0 | 0.2 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 0.1 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.0 | 0.1 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 0.0 | 0.7 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.0 | 0.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) phagosome acidification(GO:0090383) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 0.6 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.0 | 0.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.0 | 0.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.2 | 1.0 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 0.6 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
| 0.1 | 0.4 | GO:0090498 | extrinsic component of Golgi membrane(GO:0090498) |
| 0.1 | 1.0 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.1 | 1.7 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 0.4 | GO:1990393 | 3M complex(GO:1990393) |
| 0.1 | 0.2 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.0 | 0.4 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.1 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.0 | 0.2 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.0 | 0.3 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) |
| 0.0 | 0.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.2 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.4 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.4 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.0 | 0.1 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.2 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.1 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.2 | 1.3 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.2 | 2.5 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 0.5 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.2 | 1.8 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 0.5 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.1 | 0.8 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.1 | 0.3 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.1 | 0.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 0.2 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.1 | 0.4 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 0.2 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 0.1 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 0.0 | 0.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.1 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.0 | 0.5 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 0.1 | GO:0001160 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) |
| 0.0 | 0.1 | GO:0005330 | dopamine:sodium symporter activity(GO:0005330) |
| 0.0 | 0.3 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.4 | GO:0051430 | corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.2 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.0 | 0.1 | GO:0015928 | alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928) |
| 0.0 | 0.4 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.5 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.1 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.0 | 0.4 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 0.3 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 0.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.1 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.2 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.1 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.2 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.1 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.0 | 0.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.7 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.4 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 1.3 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.2 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.7 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.5 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.1 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.6 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.4 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.5 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 1.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.0 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.4 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.1 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 0.5 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 0.4 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
