Motif ID: HMX2

Z-value: 0.438


Transcription factors associated with HMX2:

Gene SymbolEntrez IDGene Name
HMX2 ENSG00000188816.3 HMX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMX2hg19_v2_chr10_+_124907638_1249076600.377.6e-02Click!


Activity profile for motif HMX2.

activity profile for motif HMX2


Sorted Z-values histogram for motif HMX2

Sorted Z-values for motif HMX2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_111174054 0.623 ENST00000369770.3
 KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr10_-_7513904 0.483 ENST00000420395.1
 RP5-1031D4.2
RP5-1031D4.2
chr1_+_209878182 0.414 ENST00000367027.3
 HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_-_146781153 0.413 ENST00000520473.1
 DPYSL3
dihydropyrimidinase-like 3
chr18_+_42260861 0.405 ENST00000282030.5
 SETBP1
SET binding protein 1
chr6_-_27858570 0.396 ENST00000359303.2
 HIST1H3J
histone cluster 1, H3j
chr13_+_24144509 0.370 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr9_+_27109392 0.368 ENST00000406359.4
 TEK
TEK tyrosine kinase, endothelial
chr2_-_160654745 0.350 ENST00000259053.4
ENST00000429078.2
 CD302

CD302 molecule

chr19_+_58144529 0.344 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
 ZNF211





zinc finger protein 211





chr18_-_24765248 0.335 ENST00000580774.1
ENST00000284224.8
 CHST9

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

chr1_-_110933611 0.335 ENST00000472422.2
ENST00000437429.2
 SLC16A4

solute carrier family 16, member 4

chr4_-_70518941 0.304 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
 UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr7_-_7680601 0.299 ENST00000396682.2
 RPA3
replication protein A3, 14kDa
chr21_-_34185944 0.297 ENST00000479548.1
 C21orf62
chromosome 21 open reading frame 62
chr6_+_151561085 0.288 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_116102562 0.283 ENST00000374193.4
ENST00000465979.1
 WDR31

WD repeat domain 31

chr10_+_32873190 0.276 ENST00000375025.4
 C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr2_+_211342432 0.273 ENST00000430249.2
 CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr8_-_93978309 0.272 ENST00000517858.1
ENST00000378861.5
 TRIQK

triple QxxK/R motif containing


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0021633 optic nerve structural organization(GO:0021633)
0.2 0.5 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.4 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.3 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.2 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.2 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0043194 spectrin-associated cytoskeleton(GO:0014731) axon initial segment(GO:0043194)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.0 GO:0031417 NatC complex(GO:0031417)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 0.5 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.1 0.4 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.3 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.0 GO:0004951 cholecystokinin receptor activity(GO:0004951)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation