Motif ID: HMX3

Z-value: 0.901


Transcription factors associated with HMX3:

Gene SymbolEntrez IDGene Name
HMX3 ENSG00000188620.9 HMX3



Activity profile for motif HMX3.

activity profile for motif HMX3


Sorted Z-values histogram for motif HMX3

Sorted Z-values for motif HMX3



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_69681710 2.635 ENST00000265403.7
ENST00000458688.2
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr9_+_99690592 2.540 ENST00000354649.3
 NUTM2G
NUT family member 2G
chr4_+_69962212 2.468 ENST00000508661.1
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_+_69962185 2.411 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr7_+_147830776 1.501 ENST00000538075.1
 CNTNAP2
contactin associated protein-like 2
chr3_+_100354442 1.451 ENST00000475887.1
 GPR128
G protein-coupled receptor 128
chr7_+_80275953 1.414 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
 CD36


CD36 molecule (thrombospondin receptor)


chr12_-_91505608 1.348 ENST00000266718.4
 LUM
lumican
chr12_+_20968608 1.190 ENST00000553473.1
ENST00000554957.1
ENST00000381541.3
ENST00000540229.1
 SLCO1B3
SLCO1B7
LST3

solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B7 (non-functional)
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein

chr18_-_74839891 0.956 ENST00000581878.1
 MBP
myelin basic protein
chr9_+_105757590 0.832 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr4_-_120243545 0.818 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr11_+_62104897 0.798 ENST00000415229.2
ENST00000535727.1
ENST00000301776.5
 ASRGL1


asparaginase like 1


chr5_+_150404904 0.795 ENST00000521632.1
 GPX3
glutathione peroxidase 3 (plasma)
chr8_+_95565947 0.768 ENST00000523011.1
 RP11-267M23.4
RP11-267M23.4
chr6_+_134758827 0.763 ENST00000431422.1
 LINC01010
long intergenic non-protein coding RNA 1010
chr9_+_130159409 0.734 ENST00000373371.3
 SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr6_+_12290586 0.712 ENST00000379375.5
 EDN1
endothelin 1
chr6_-_76782371 0.692 ENST00000369950.3
ENST00000369963.3
 IMPG1

interphotoreceptor matrix proteoglycan 1

chr1_+_87012753 0.667 ENST00000370563.3
 CLCA4
chloride channel accessory 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 211 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.3 2.3 GO:0070543 response to linoleic acid(GO:0070543)
0.2 1.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 1.5 GO:0071109 superior temporal gyrus development(GO:0071109)
0.3 1.3 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.2 1.0 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 1.0 GO:0007141 male meiosis I(GO:0007141)
0.0 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 0.9 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.8 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.8 GO:0006528 asparagine metabolic process(GO:0006528)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.7 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.7 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.7 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.3 GO:0033010 paranodal junction(GO:0033010)
0.1 1.0 GO:0033269 internode region of axon(GO:0033269)
0.0 1.0 GO:0032982 myosin filament(GO:0032982)
0.3 0.9 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.9 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0034681 integrin alpha1-beta1 complex(GO:0034665) integrin alpha3-beta1 complex(GO:0034667) integrin alpha10-beta1 complex(GO:0034680) integrin alpha11-beta1 complex(GO:0034681)
0.1 0.3 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 2.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 1.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.3 1.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 0.8 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.8 GO:0008430 selenium binding(GO:0008430)
0.1 0.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.7 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.0 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_DEFENSINS Genes involved in Defensins
0.0 0.8 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling