Motif ID: HNF1A_HNF1B
Z-value: 0.942
Transcription factors associated with HNF1A_HNF1B:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
HNF1A | ENSG00000135100.13 | HNF1A |
HNF1B | ENSG00000108753.8 | HNF1B |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
HNF1A | hg19_v2_chr12_+_121416340_121416371 | -0.47 | 1.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.0 | GO:0000023 | maltose metabolic process(GO:0000023) |
0.4 | 2.2 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
0.4 | 3.4 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
0.4 | 3.7 | GO:0015889 | cobalamin transport(GO:0015889) |
0.3 | 2.0 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
0.3 | 1.0 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
0.3 | 1.1 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.2 | 0.7 | GO:1904106 | protein localization to microvillus(GO:1904106) |
0.2 | 0.6 | GO:0010621 | negative regulation of transcription by transcription factor localization(GO:0010621) |
0.2 | 0.9 | GO:0044245 | polysaccharide digestion(GO:0044245) |
0.2 | 0.5 | GO:0090294 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
0.2 | 0.5 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
0.2 | 0.6 | GO:0051958 | methotrexate transport(GO:0051958) |
0.1 | 0.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.1 | 0.7 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
0.1 | 1.0 | GO:0009441 | glycolate metabolic process(GO:0009441) |
0.1 | 0.9 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.1 | 0.3 | GO:0070173 | regulation of enamel mineralization(GO:0070173) |
0.1 | 0.2 | GO:0016539 | intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) negative regulation of dopaminergic neuron differentiation(GO:1904339) |
0.1 | 10.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
0.1 | 0.5 | GO:0048014 | Tie signaling pathway(GO:0048014) |
0.1 | 0.1 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
0.1 | 0.2 | GO:2001027 | negative regulation of endothelial cell chemotaxis(GO:2001027) |
0.1 | 0.3 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
0.1 | 0.4 | GO:0000066 | mitochondrial ornithine transport(GO:0000066) |
0.0 | 0.2 | GO:0007402 | ganglion mother cell fate determination(GO:0007402) |
0.0 | 0.4 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
0.0 | 0.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
0.0 | 0.3 | GO:0070560 | protein secretion by platelet(GO:0070560) |
0.0 | 1.2 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
0.0 | 0.4 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509) |
0.0 | 0.2 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
0.0 | 0.2 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
0.0 | 0.5 | GO:0008228 | opsonization(GO:0008228) |
0.0 | 0.1 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.0 | 0.3 | GO:0006848 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
0.0 | 0.5 | GO:0006069 | ethanol oxidation(GO:0006069) |
0.0 | 0.2 | GO:0030538 | embryonic genitalia morphogenesis(GO:0030538) |
0.0 | 0.5 | GO:0015866 | ADP transport(GO:0015866) |
0.0 | 0.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
0.0 | 0.1 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
0.0 | 0.1 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
0.0 | 0.8 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
0.0 | 1.1 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.0 | 1.3 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.0 | 0.4 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
0.0 | 0.2 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
0.0 | 0.8 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
0.0 | 0.1 | GO:0051182 | coenzyme transport(GO:0051182) |
0.0 | 0.1 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
0.0 | 0.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.0 | 0.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
0.0 | 0.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.0 | 0.2 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
0.0 | 1.2 | GO:0006953 | acute-phase response(GO:0006953) |
0.0 | 2.0 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
0.0 | 0.1 | GO:0061107 | seminal vesicle development(GO:0061107) |
0.0 | 0.5 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
0.0 | 0.4 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
0.0 | 0.2 | GO:0034378 | chylomicron assembly(GO:0034378) |
0.0 | 0.0 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
0.0 | 0.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
0.0 | 1.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 1.4 | GO:0035383 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
0.0 | 0.5 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
0.1 | 0.6 | GO:0005579 | membrane attack complex(GO:0005579) |
0.0 | 0.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.0 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.1 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
0.0 | 0.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.0 | 2.0 | GO:0031904 | endosome lumen(GO:0031904) |
0.0 | 3.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.0 | 2.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
0.0 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.1 | GO:0044326 | dendritic spine neck(GO:0044326) |
0.0 | 0.1 | GO:0036025 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
0.0 | 0.6 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 1.6 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.0 | 1.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 0.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 1.3 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.0 | 0.2 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
0.9 | 3.5 | GO:0016160 | amylase activity(GO:0016160) |
0.9 | 3.4 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.5 | 1.4 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
0.4 | 2.0 | GO:0004925 | prolactin receptor activity(GO:0004925) |
0.3 | 3.7 | GO:0031419 | cobalamin binding(GO:0031419) |
0.3 | 1.1 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.3 | 1.8 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
0.2 | 1.4 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
0.2 | 0.5 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
0.2 | 0.6 | GO:0015350 | methotrexate transporter activity(GO:0015350) |
0.1 | 0.6 | GO:0035939 | microsatellite binding(GO:0035939) |
0.1 | 10.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.1 | 0.4 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
0.1 | 1.3 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 0.9 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
0.1 | 0.8 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
0.1 | 1.2 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
0.1 | 0.5 | GO:0034046 | poly(G) binding(GO:0034046) |
0.1 | 0.4 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
0.1 | 0.4 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.1 | 1.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 0.3 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
0.1 | 0.5 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
0.1 | 0.4 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
0.0 | 0.2 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
0.0 | 0.4 | GO:0043559 | insulin binding(GO:0043559) |
0.0 | 0.7 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.0 | 0.2 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
0.0 | 0.3 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.0 | 0.2 | GO:0004522 | ribonuclease A activity(GO:0004522) |
0.0 | 0.5 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
0.0 | 0.2 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.0 | 0.2 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.0 | 0.1 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
0.0 | 0.2 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
0.0 | 0.3 | GO:0019826 | oxygen sensor activity(GO:0019826) |
0.0 | 0.2 | GO:0030250 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
0.0 | 0.1 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
0.0 | 0.1 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 1.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.7 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 0.0 | GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124) |
0.0 | 0.1 | GO:0033265 | choline binding(GO:0033265) |
0.0 | 0.1 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
0.0 | 0.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.0 | 0.2 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.4 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
0.0 | 0.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 1.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.2 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.6 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.0 | 1.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.7 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 0.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 0.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 4.5 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
0.4 | 10.5 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.2 | 3.5 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.1 | 2.0 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.1 | 1.0 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
0.0 | 1.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.0 | 0.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.0 | 1.2 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 0.7 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
0.0 | 0.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.7 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.9 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
0.0 | 0.2 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.0 | 1.3 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
0.0 | 0.5 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |