Motif ID: HNF1A_HNF1B

Z-value: 0.942

Transcription factors associated with HNF1A_HNF1B:

Gene SymbolEntrez IDGene Name
HNF1A ENSG00000135100.13 HNF1A
HNF1B ENSG00000108753.8 HNF1B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416340_121416371-0.471.9e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_110723194 3.503 ENST00000394635.3
CFI
complement factor I
chr4_-_110723134 3.499 ENST00000510800.1
ENST00000512148.1
CFI

complement factor I

chr4_-_110723335 3.214 ENST00000394634.2
CFI
complement factor I
chrX_-_15619076 2.210 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr19_+_50016610 2.088 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_35195338 2.029 ENST00000509839.1
PRLR
prolactin receptor
chr7_+_141695671 1.486 ENST00000497673.1
ENST00000475668.2
MGAM

maltase-glucoamylase (alpha-glucosidase)

chr6_-_29013017 1.481 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr7_+_141695633 1.475 ENST00000549489.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_+_18807424 1.343 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chr19_+_50016411 1.342 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr22_+_31003133 1.287 ENST00000405742.3
TCN2
transcobalamin II
chr17_-_202579 1.273 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL


rabphilin 3A-like (without C2 domains)


chr17_+_4692230 1.264 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr20_-_7921090 1.257 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr14_-_94854926 1.254 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
SERPINA1


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1


chr22_+_31003190 1.240 ENST00000407817.3
TCN2
transcobalamin II
chr16_+_20775358 1.238 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr22_+_31002779 1.157 ENST00000215838.3
TCN2
transcobalamin II
chr17_+_26800756 1.139 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr17_+_26800648 1.128 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr1_+_162351503 1.126 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr8_-_95220775 1.069 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17


cadherin 17, LI cadherin (liver-intestine)


chr17_+_26800296 1.035 ENST00000444914.3
ENST00000314669.5
SLC13A2

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

chr12_+_109785708 1.009 ENST00000310903.5
MYO1H
myosin IH
chr7_-_50633078 0.973 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr22_-_32651326 0.915 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr13_+_96085847 0.895 ENST00000376873.3
CLDN10
claudin 10
chr17_+_68071458 0.790 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr3_-_74570291 0.782 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr17_+_68071389 0.777 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr16_-_55909255 0.754 ENST00000290567.9
CES5A
carboxylesterase 5A
chr16_-_55909272 0.754 ENST00000319165.9
CES5A
carboxylesterase 5A
chr16_-_55909211 0.746 ENST00000520435.1
CES5A
carboxylesterase 5A
chrX_-_105282712 0.741 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_+_21244986 0.712 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr1_+_104293028 0.686 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr9_-_123812542 0.677 ENST00000223642.1
C5
complement component 5
chr22_-_30968813 0.657 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1


galactose-3-O-sulfotransferase 1


chr17_-_26733179 0.633 ENST00000440501.1
ENST00000321666.5
SLC46A1

solute carrier family 46 (folate transporter), member 1

chr3_-_157221380 0.621 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr17_+_35732955 0.612 ENST00000300618.4
C17orf78
chromosome 17 open reading frame 78
chr17_+_35732916 0.591 ENST00000586700.1
C17orf78
chromosome 17 open reading frame 78
chr5_-_61031495 0.586 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2

CTD-2170G1.2

chr3_-_157221357 0.561 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_126070726 0.559 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr6_-_52628271 0.530 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr12_-_91574142 0.525 ENST00000547937.1
DCN
decorin
chr2_+_38177575 0.523 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2



regulator of microtubule dynamics 2



chr3_-_137834436 0.515 ENST00000327532.2
ENST00000467030.1
DZIP1L

DAZ interacting zinc finger protein 1-like

chr1_+_104159999 0.509 ENST00000414303.2
ENST00000423678.1
AMY2A

amylase, alpha 2A (pancreatic)

chr6_+_47624172 0.503 ENST00000507065.1
ENST00000296862.1
GPR111

G protein-coupled receptor 111

chr6_-_154751629 0.501 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr8_-_108510224 0.478 ENST00000517746.1
ENST00000297450.3
ANGPT1

angiopoietin 1

chr2_-_55920952 0.475 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr4_-_70518941 0.472 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr4_-_100212132 0.472 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr10_+_45406627 0.470 ENST00000389583.4
TMEM72
transmembrane protein 72
chr6_+_54173227 0.459 ENST00000259782.4
ENST00000370864.3
TINAG

tubulointerstitial nephritis antigen

chr1_-_168464875 0.454 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr6_-_25930819 0.442 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr12_+_20963647 0.426 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr10_-_61495760 0.425 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr12_-_39837192 0.412 ENST00000361961.3
ENST00000395670.3
KIF21A

kinesin family member 21A

chr6_-_51952367 0.412 ENST00000340994.4
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr2_-_228244013 0.406 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr6_+_12717892 0.403 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr6_-_25930904 0.402 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr12_+_20963632 0.400 ENST00000540853.1
ENST00000261196.2
SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr4_-_76944621 0.385 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr8_-_70745575 0.381 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr4_-_1166954 0.380 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2


spondin 2, extracellular matrix protein


chr8_+_104892639 0.379 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_51952418 0.377 ENST00000371117.3
PKHD1
polycystic kidney and hepatic disease 1 (autosomal recessive)
chr3_-_164796269 0.376 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr2_+_133174147 0.368 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr5_+_140571902 0.367 ENST00000239446.4
PCDHB10
protocadherin beta 10
chr11_-_65149422 0.364 ENST00000526432.1
ENST00000527174.1
SLC25A45

solute carrier family 25, member 45

chr5_+_67586465 0.363 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr13_-_103719196 0.362 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr14_-_57960545 0.361 ENST00000526336.1
ENST00000216445.3
C14orf105

chromosome 14 open reading frame 105

chr8_-_87242589 0.355 ENST00000419776.2
ENST00000297524.3
SLC7A13

solute carrier family 7 (anionic amino acid transporter), member 13

chr5_-_111093167 0.338 ENST00000446294.2
ENST00000419114.2
NREP

neuronal regeneration related protein

chr19_+_11350278 0.323 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr17_+_79953310 0.318 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr6_+_54172653 0.302 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr17_+_1646130 0.288 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2




serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2




chr19_+_41305085 0.287 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr12_-_8693469 0.284 ENST00000545274.1
ENST00000446457.2
CLEC4E

C-type lectin domain family 4, member E

chr1_+_207277590 0.280 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr2_+_115219171 0.274 ENST00000409163.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr16_-_69385681 0.263 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_71494461 0.263 ENST00000396073.3
ENAM
enamelin
chr4_+_3443614 0.260 ENST00000382774.3
ENST00000511533.1
HGFAC

HGF activator

chr12_+_60058458 0.252 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_+_21911054 0.251 ENST00000519850.1
ENST00000381470.3
DMTN

dematin actin binding protein

chr3_-_169587621 0.247 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31


leucine rich repeat containing 31


chr14_+_39703112 0.246 ENST00000555143.1
ENST00000280082.3
MIA2

melanoma inhibitory activity 2

chr7_-_155601766 0.245 ENST00000430104.1
SHH
sonic hedgehog
chr8_-_17752996 0.242 ENST00000381841.2
ENST00000427924.1
FGL1

fibrinogen-like 1

chr3_-_49466686 0.240 ENST00000273598.3
ENST00000436744.2
NICN1

nicolin 1

chr15_-_99057551 0.239 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr9_+_130860583 0.238 ENST00000373064.5
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr6_+_131571535 0.228 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr4_+_159443090 0.227 ENST00000343542.5
ENST00000470033.1
RXFP1

relaxin/insulin-like family peptide receptor 1

chr22_-_30970560 0.223 ENST00000402369.1
ENST00000406361.1
GAL3ST1

galactose-3-O-sulfotransferase 1

chr9_+_130860810 0.221 ENST00000433501.1
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr14_+_21156915 0.215 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr5_-_10761206 0.211 ENST00000432074.2
ENST00000230895.6
DAP

death-associated protein

chr3_+_183948161 0.210 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr1_-_42630389 0.210 ENST00000357001.2
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr6_-_161085291 0.207 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr11_-_111649015 0.205 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr11_+_560956 0.204 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7


Ras association (RalGDS/AF-6) domain family (N-terminal) member 7


chr7_-_47579188 0.203 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3



tensin 3



chr2_-_88427568 0.201 ENST00000393750.3
ENST00000295834.3
FABP1

fatty acid binding protein 1, liver

chr20_+_43029911 0.200 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A


hepatocyte nuclear factor 4, alpha


chr11_-_117695449 0.196 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr19_-_49565254 0.195 ENST00000593537.1
NTF4
neurotrophin 4
chr2_-_158300556 0.194 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr3_+_185431080 0.192 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr11_+_46740730 0.191 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2


coagulation factor II (thrombin)


chr1_+_119911425 0.183 ENST00000361035.4
ENST00000325945.3
HAO2

hydroxyacid oxidase 2 (long chain)

chr12_+_100867486 0.182 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_+_186383741 0.177 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr6_-_25874440 0.175 ENST00000361703.6
ENST00000397060.4
SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr1_+_36789335 0.175 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr9_-_94712434 0.173 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr12_+_100867694 0.154 ENST00000392986.3
ENST00000549996.1
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr11_-_128894053 0.153 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr4_+_100495864 0.153 ENST00000265517.5
ENST00000422897.2
MTTP

microsomal triglyceride transfer protein

chr16_-_15474904 0.152 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr7_-_6098770 0.151 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1


eukaryotic translation initiation factor 2-alpha kinase 1


chr4_-_74486109 0.145 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_76879852 0.144 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr12_+_100897130 0.142 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4


nuclear receptor subfamily 1, group H, member 4


chr10_-_38146510 0.133 ENST00000395867.3
ZNF248
zinc finger protein 248
chr12_-_91546926 0.132 ENST00000550758.1
DCN
decorin
chr3_+_75955817 0.131 ENST00000487694.3
ENST00000602589.1
ROBO2

roundabout, axon guidance receptor, homolog 2 (Drosophila)

chr4_-_74486347 0.128 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_-_116833500 0.127 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr7_+_152456829 0.126 ENST00000377776.3
ENST00000256001.8
ENST00000397282.2
ACTR3B


ARP3 actin-related protein 3 homolog B (yeast)


chr11_+_2405833 0.124 ENST00000527343.1
ENST00000464784.2
CD81

CD81 molecule

chr2_-_162931052 0.124 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr16_+_20775024 0.123 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr10_+_111765562 0.123 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr10_-_128359074 0.121 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr16_-_57831676 0.114 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3


kinesin family member C3


chr17_+_48823896 0.113 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr9_+_82186872 0.112 ENST00000376544.3
ENST00000376520.4
TLE4

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

chr12_+_40787194 0.110 ENST00000425730.2
ENST00000454784.4
MUC19

mucin 19, oligomeric

chrX_+_36254051 0.110 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr2_+_109223595 0.094 ENST00000410093.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_110284384 0.093 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr11_-_83393457 0.090 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr6_+_25754927 0.090 ENST00000377905.4
ENST00000439485.2
SLC17A4

solute carrier family 17, member 4

chr12_-_8693539 0.090 ENST00000299663.3
CLEC4E
C-type lectin domain family 4, member E
chr19_-_42133420 0.083 ENST00000221954.2
ENST00000600925.1
CEACAM4

carcinoembryonic antigen-related cell adhesion molecule 4

chr3_+_180319918 0.077 ENST00000296015.4
ENST00000491380.1
ENST00000412756.2
ENST00000382584.4
TTC14



tetratricopeptide repeat domain 14



chr3_+_66271410 0.075 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr5_+_140772381 0.075 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr4_-_987164 0.074 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr13_+_27825706 0.073 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21


ribosomal protein L21


chr7_-_87856280 0.072 ENST00000490437.1
ENST00000431660.1
SRI

sorcin

chr7_-_87856303 0.071 ENST00000394641.3
SRI
sorcin
chr1_-_159684371 0.071 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP





C-reactive protein, pentraxin-related





chr11_+_20620946 0.069 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr14_+_24590560 0.068 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr4_-_166034029 0.068 ENST00000306480.6
TMEM192
transmembrane protein 192
chr10_-_52645379 0.067 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr10_-_32667660 0.064 ENST00000375110.2
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr5_-_138718973 0.063 ENST00000353963.3
ENST00000348729.3
SLC23A1

solute carrier family 23 (ascorbic acid transporter), member 1

chr14_+_95027772 0.058 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4

SERPINA5

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

chr4_+_155484155 0.057 ENST00000509493.1
FGB
fibrinogen beta chain
chr8_-_87755878 0.055 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr17_+_41052808 0.054 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC


glucose-6-phosphatase, catalytic subunit


chr13_-_41593425 0.053 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_+_152456904 0.052 ENST00000537264.1
ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
chr10_-_52645416 0.051 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF





APOBEC1 complementation factor





chr16_-_20587599 0.051 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B







acyl-CoA synthetase medium-chain family member 2B







chr18_-_48346415 0.050 ENST00000431965.2
ENST00000436348.2
MRO

maestro

chr18_+_5748793 0.048 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1

RP11-945C19.1

chr4_+_187187337 0.045 ENST00000492972.2
F11
coagulation factor XI
chr3_-_137893721 0.045 ENST00000505015.2
ENST00000260803.4
DBR1

debranching RNA lariats 1

chr10_-_72648541 0.044 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr12_+_70133152 0.044 ENST00000550536.1
ENST00000362025.5
RAB3IP

RAB3A interacting protein

chr17_+_73642486 0.043 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr17_+_48823975 0.042 ENST00000513969.1
ENST00000503728.1
LUC7L3

LUC7-like 3 (S. cerevisiae)

chrX_-_124097620 0.041 ENST00000371130.3
ENST00000422452.2
TENM1

teneurin transmembrane protein 1

chr4_-_102267953 0.039 ENST00000523694.2
ENST00000507176.1
PPP3CA

protein phosphatase 3, catalytic subunit, alpha isozyme

chr22_+_32439019 0.037 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr3_+_107318157 0.037 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr20_+_57414743 0.031 ENST00000313949.7
GNAS
GNAS complex locus
chr16_+_20462783 0.031 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
ACSM2A








acyl-CoA synthetase medium-chain family member 2A








chr11_+_64358686 0.030 ENST00000473690.1
SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12
chr9_+_140125385 0.030 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr3_+_72200408 0.029 ENST00000473713.1
LINC00870
long intergenic non-protein coding RNA 870
chr1_+_66999799 0.029 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1


SH3-domain GRB2-like (endophilin) interacting protein 1


chr9_+_140125209 0.029 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr2_-_47572105 0.028 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4



AC073283.4




Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0000023 maltose metabolic process(GO:0000023)
0.4 2.2 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.4 3.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.4 3.7 GO:0015889 cobalamin transport(GO:0015889)
0.3 2.0 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 1.0 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.3 1.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.7 GO:1904106 protein localization to microvillus(GO:1904106)
0.2 0.6 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.2 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 0.5 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 0.5 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 0.6 GO:0051958 methotrexate transport(GO:0051958)
0.1 0.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.7 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 1.0 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 10.7 GO:0030449 regulation of complement activation(GO:0030449)
0.1 0.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.3 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 1.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.2 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.5 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.3 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.5 GO:0015866 ADP transport(GO:0015866)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 1.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.8 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 1.2 GO:0006953 acute-phase response(GO:0006953)
0.0 2.0 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.4 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.0 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 1.5 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 2.0 GO:0031904 endosome lumen(GO:0031904)
0.0 3.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.9 3.5 GO:0016160 amylase activity(GO:0016160)
0.9 3.4 GO:0019770 IgG receptor activity(GO:0019770)
0.5 1.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.4 2.0 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 3.7 GO:0031419 cobalamin binding(GO:0031419)
0.3 1.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.3 1.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 1.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 0.5 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.2 0.6 GO:0015350 methotrexate transporter activity(GO:0015350)
0.1 0.6 GO:0035939 microsatellite binding(GO:0035939)
0.1 10.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 1.3 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.8 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 1.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.5 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.4 GO:0043559 insulin binding(GO:0043559)
0.0 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.3 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.3 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.4 10.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 3.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.0 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation