Motif ID: HNF1A_HNF1B

Z-value: 0.942

Transcription factors associated with HNF1A_HNF1B:

Gene SymbolEntrez IDGene Name
HNF1A ENSG00000135100.13 HNF1A
HNF1B ENSG00000108753.8 HNF1B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416340_121416371-0.471.9e-02Click!


Activity profile for motif HNF1A_HNF1B.

activity profile for motif HNF1A_HNF1B


Sorted Z-values histogram for motif HNF1A_HNF1B

Sorted Z-values for motif HNF1A_HNF1B



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_110723194 3.503 ENST00000394635.3
 CFI
complement factor I
chr4_-_110723134 3.499 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr4_-_110723335 3.214 ENST00000394634.2
 CFI
complement factor I
chrX_-_15619076 2.210 ENST00000252519.3
 ACE2
angiotensin I converting enzyme 2
chr19_+_50016610 2.088 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_35195338 2.029 ENST00000509839.1
 PRLR
prolactin receptor
chr7_+_141695671 1.486 ENST00000497673.1
ENST00000475668.2
 MGAM

maltase-glucoamylase (alpha-glucosidase)

chr6_-_29013017 1.481 ENST00000377175.1
 OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr7_+_141695633 1.475 ENST00000549489.2
 MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_+_18807424 1.343 ENST00000400664.1
 KLHDC7A
kelch domain containing 7A
chr19_+_50016411 1.342 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
 FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr22_+_31003133 1.287 ENST00000405742.3
 TCN2
transcobalamin II
chr17_-_202579 1.273 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
 RPH3AL


rabphilin 3A-like (without C2 domains)


chr17_+_4692230 1.264 ENST00000331264.7
 GLTPD2
glycolipid transfer protein domain containing 2
chr20_-_7921090 1.257 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr14_-_94854926 1.254 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
 SERPINA1


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1


chr22_+_31003190 1.240 ENST00000407817.3
 TCN2
transcobalamin II
chr16_+_20775358 1.238 ENST00000440284.2
 ACSM3
acyl-CoA synthetase medium-chain family member 3
chr22_+_31002779 1.157 ENST00000215838.3
 TCN2
transcobalamin II
chr17_+_26800756 1.139 ENST00000537681.1
 SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0030449 regulation of complement activation(GO:0030449)
0.4 3.7 GO:0015889 cobalamin transport(GO:0015889)
0.4 3.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.6 3.0 GO:0000023 maltose metabolic process(GO:0000023)
0.4 2.2 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.3 2.0 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 2.0 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.5 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 1.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.2 GO:0006953 acute-phase response(GO:0006953)
0.3 1.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.3 1.0 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.1 1.0 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.0 GO:0031904 endosome lumen(GO:0031904)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 3.7 GO:0031419 cobalamin binding(GO:0031419)
0.9 3.5 GO:0016160 amylase activity(GO:0016160)
0.9 3.4 GO:0019770 IgG receptor activity(GO:0019770)
1.1 3.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.4 2.0 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 1.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.5 1.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 1.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 1.3 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.8 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009)
0.2 0.6 GO:0015350 methotrexate transporter activity(GO:0015350)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.5 4.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 3.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.0 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins