Motif ID: HOXA1

Z-value: 0.572


Transcription factors associated with HOXA1:

Gene SymbolEntrez IDGene Name
HOXA1 ENSG00000105991.7 HOXA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA1hg19_v2_chr7_-_27135591_27135658-0.291.6e-01Click!


Activity profile for motif HOXA1.

activity profile for motif HOXA1


Sorted Z-values histogram for motif HOXA1

Sorted Z-values for motif HOXA1



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_30866564 1.389 ENST00000435069.1
ENST00000415957.2
ENST00000540910.1
 SEC14L3


SEC14-like 3 (S. cerevisiae)


chr8_+_104152922 0.929 ENST00000309982.5
ENST00000438105.2
ENST00000297574.6
 BAALC


brain and acute leukemia, cytoplasmic


chr15_-_93616340 0.824 ENST00000557420.1
ENST00000542321.2
 RGMA

repulsive guidance molecule family member a

chr20_+_31669333 0.820 ENST00000375483.3
 BPIFB4
BPI fold containing family B, member 4
chr2_-_154335300 0.810 ENST00000325926.3
 RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr10_-_28270795 0.761 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr8_-_27115931 0.730 ENST00000523048.1
 STMN4
stathmin-like 4
chr1_+_85527987 0.673 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr12_-_71533055 0.659 ENST00000552128.1
 TSPAN8
tetraspanin 8
chr3_-_112564797 0.576 ENST00000398214.1
ENST00000448932.1
 CD200R1L

CD200 receptor 1-like

chr17_+_68071389 0.570 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_+_26800296 0.556 ENST00000444914.3
ENST00000314669.5
 SLC13A2

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

chr14_+_96949319 0.555 ENST00000554706.1
 AK7
adenylate kinase 7
chr13_+_36050881 0.554 ENST00000537702.1
 NBEA
neurobeachin
chr22_+_25615489 0.546 ENST00000398215.2
 CRYBB2
crystallin, beta B2
chr8_-_27468842 0.524 ENST00000523500.1
 CLU
clusterin
chr8_-_27468945 0.511 ENST00000405140.3
 CLU
clusterin
chr2_+_8822113 0.484 ENST00000396290.1
ENST00000331129.3
 ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr8_+_1993173 0.478 ENST00000523438.1
 MYOM2
myomesin 2
chr15_-_43513187 0.464 ENST00000540029.1
ENST00000441366.2
 EPB42

erythrocyte membrane protein band 4.2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.8 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 1.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.8 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.2 0.5 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.5 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.4 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.4 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.3 GO:0042495 detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.1 0.3 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.1 0.3 GO:0030185 nitric oxide transport(GO:0030185)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.3 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.9 GO:0032982 myosin filament(GO:0032982)
0.0 0.9 GO:0030286 dynein complex(GO:0030286)
0.0 0.8 GO:0097546 ciliary base(GO:0097546)
0.1 0.3 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.1 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 1.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.2 0.6 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 0.6 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.5 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0042609 CD4 receptor binding(GO:0042609)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 0.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters