Motif ID: HOXA10_HOXB9

Z-value: 0.468

Transcription factors associated with HOXA10_HOXB9:

Gene SymbolEntrez IDGene Name
HOXA10 ENSG00000253293.3 HOXA10
HOXB9 ENSG00000170689.8 HOXB9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA10hg19_v2_chr7_-_27213893_27213954-0.621.3e-03Click!
HOXB9hg19_v2_chr17_-_46703826_46703845-0.433.8e-02Click!


Activity profile for motif HOXA10_HOXB9.

activity profile for motif HOXA10_HOXB9


Sorted Z-values histogram for motif HOXA10_HOXB9

Sorted Z-values for motif HOXA10_HOXB9



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA10_HOXB9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_160231451 0.853 ENST00000495887.1
 DCAF8
DDB1 and CUL4 associated factor 8
chr5_-_88119580 0.461 ENST00000539796.1
 MEF2C
myocyte enhancer factor 2C
chr20_-_7921090 0.447 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr15_+_40886199 0.443 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
 CASC5


cancer susceptibility candidate 5


chr5_+_98109322 0.393 ENST00000513185.1
 RGMB
repulsive guidance molecule family member b
chr12_-_95945246 0.370 ENST00000258499.3
 USP44
ubiquitin specific peptidase 44
chr7_+_35756186 0.355 ENST00000430518.1
 AC018647.3
AC018647.3
chr3_+_169629354 0.355 ENST00000428432.2
ENST00000335556.3
 SAMD7

sterile alpha motif domain containing 7

chr7_-_41742697 0.348 ENST00000242208.4
 INHBA
inhibin, beta A
chr12_+_20963632 0.335 ENST00000540853.1
ENST00000261196.2
 SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr12_+_20963647 0.328 ENST00000381545.3
 SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr10_+_102106829 0.327 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr14_+_73706308 0.327 ENST00000554301.1
ENST00000555445.1
 PAPLN

papilin, proteoglycan-like sulfated glycoprotein

chr12_+_64173583 0.319 ENST00000261234.6
 TMEM5
transmembrane protein 5
chr18_-_19994830 0.312 ENST00000525417.1
 CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr12_-_90049878 0.291 ENST00000359142.3
 ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr6_+_46761118 0.287 ENST00000230588.4
 MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr1_+_244515930 0.284 ENST00000366537.1
ENST00000308105.4
 C1orf100

chromosome 1 open reading frame 100

chr19_+_21106081 0.270 ENST00000300540.3
ENST00000595854.1
ENST00000601284.1
ENST00000328178.8
ENST00000599885.1
ENST00000596476.1
ENST00000345030.6
 ZNF85






zinc finger protein 85






chr12_-_90049828 0.269 ENST00000261173.2
ENST00000348959.3
 ATP2B1

ATPase, Ca++ transporting, plasma membrane 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.6 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 0.5 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.3 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0035799 ureter maturation(GO:0035799)
0.0 0.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.4 GO:1990423 RZZ complex(GO:1990423)
0.1 0.3 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.0 GO:1990032 parallel fiber(GO:1990032)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.2 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.2 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.2 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling