Motif ID: HOXA2_HOXB1

Z-value: 0.560

Transcription factors associated with HOXA2_HOXB1:

Gene SymbolEntrez IDGene Name
HOXA2 ENSG00000105996.5 HOXA2
HOXB1 ENSG00000120094.6 HOXB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_271424300.203.4e-01Click!
HOXB1hg19_v2_chr17_-_46608272_466083850.029.2e-01Click!


Activity profile for motif HOXA2_HOXB1.

activity profile for motif HOXA2_HOXB1


Sorted Z-values histogram for motif HOXA2_HOXB1

Sorted Z-values for motif HOXA2_HOXB1



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_151561506 2.472 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_151561085 2.376 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_205391178 1.351 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr2_-_190044480 1.277 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr11_-_2162162 1.247 ENST00000381389.1
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_-_74501360 1.238 ENST00000323940.5
 STRA6
stimulated by retinoic acid 6
chr11_-_111782484 0.905 ENST00000533971.1
 CRYAB
crystallin, alpha B
chr4_-_90757364 0.727 ENST00000508895.1
 SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr10_-_100995540 0.686 ENST00000370546.1
ENST00000404542.1
 HPSE2

heparanase 2

chr11_-_111782696 0.674 ENST00000227251.3
ENST00000526180.1
 CRYAB

crystallin, alpha B

chr17_-_46623441 0.663 ENST00000330070.4
 HOXB2
homeobox B2
chr4_-_90756769 0.659 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
 SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr3_-_51813009 0.619 ENST00000398780.3
 IQCF6
IQ motif containing F6
chr17_+_37824700 0.608 ENST00000581428.1
 PNMT
phenylethanolamine N-methyltransferase
chr19_-_51512804 0.555 ENST00000594211.1
ENST00000376832.4
 KLK9

kallikrein-related peptidase 9

chr17_+_39975544 0.539 ENST00000544340.1
 FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_39975455 0.516 ENST00000455106.1
 FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_37824217 0.502 ENST00000394246.1
 PNMT
phenylethanolamine N-methyltransferase
chr15_-_64673630 0.499 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
 KIAA0101


KIAA0101


chr12_+_21168630 0.477 ENST00000421593.2
 SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 1.6 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 1.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 1.4 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.4 1.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 1.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 1.3 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 1.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.4 1.1 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.7 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.1 0.3 GO:0007538 primary sex determination(GO:0007538)
0.1 0.3 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0005938 cell cortex(GO:0005938)
0.0 1.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 1.3 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 0.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 1.6 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 1.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 1.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.0 GO:0030305 heparanase activity(GO:0030305)
0.0 0.5 GO:0031432 titin binding(GO:0031432)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 0.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols