Motif ID: HOXA4

Z-value: 0.468


Transcription factors associated with HOXA4:

Gene SymbolEntrez IDGene Name
HOXA4 ENSG00000197576.9 HOXA4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27170352_27170418-0.546.2e-03Click!


Activity profile for motif HOXA4.

activity profile for motif HOXA4


Sorted Z-values histogram for motif HOXA4

Sorted Z-values for motif HOXA4



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA4

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39211463 1.838 ENST00000542910.1
ENST00000398477.1
 KRTAP2-2

keratin associated protein 2-2

chr2_+_128403720 0.620 ENST00000272644.3
 GPR17
G protein-coupled receptor 17
chr2_+_128403439 0.609 ENST00000544369.1
 GPR17
G protein-coupled receptor 17
chr10_+_77056134 0.601 ENST00000528121.1
ENST00000416398.1
 ZNF503-AS1

ZNF503 antisense RNA 1

chr11_-_69633792 0.567 ENST00000334134.2
 FGF3
fibroblast growth factor 3
chr9_+_75263565 0.479 ENST00000396237.3
 TMC1
transmembrane channel-like 1
chr2_-_69098566 0.431 ENST00000295379.1
 BMP10
bone morphogenetic protein 10
chr8_+_22424551 0.376 ENST00000523348.1
 SORBS3
sorbin and SH3 domain containing 3
chr8_-_95449155 0.370 ENST00000481490.2
 FSBP
fibrinogen silencer binding protein
chr4_+_84457250 0.364 ENST00000395226.2
 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr4_+_84457529 0.351 ENST00000264409.4
 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr12_+_29376592 0.349 ENST00000182377.4
 FAR2
fatty acyl CoA reductase 2
chr11_-_5364809 0.349 ENST00000300773.2
 OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr12_+_29376673 0.345 ENST00000547116.1
 FAR2
fatty acyl CoA reductase 2
chrX_+_41548220 0.343 ENST00000378142.4
 GPR34
G protein-coupled receptor 34
chrX_+_41548259 0.342 ENST00000378138.5
 GPR34
G protein-coupled receptor 34
chr3_+_159557637 0.336 ENST00000445224.2
 SCHIP1
schwannomin interacting protein 1
chr22_+_26138108 0.330 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
 MYO18B


myosin XVIIIB


chr1_-_42384343 0.328 ENST00000372584.1
 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr19_+_45409011 0.325 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
 APOE


apolipoprotein E



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0031424 keratinization(GO:0031424)
0.1 1.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.7 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.7 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.6 GO:0055026 negative regulation of cardiac muscle tissue development(GO:0055026)
0.1 0.5 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.3 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.1 0.3 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.3 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.3 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.2 GO:0050894 determination of affect(GO:0050894)
0.1 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.2 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.5 GO:0044308 axonal spine(GO:0044308)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1 0.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.1 0.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.2 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling