Motif ID: HOXA6

Z-value: 0.406


Transcription factors associated with HOXA6:

Gene SymbolEntrez IDGene Name
HOXA6 ENSG00000106006.6 HOXA6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA6hg19_v2_chr7_-_27187393_27187393-0.038.8e-01Click!


Activity profile for motif HOXA6.

activity profile for motif HOXA6


Sorted Z-values histogram for motif HOXA6

Sorted Z-values for motif HOXA6



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_27183263 0.738 ENST00000222726.3
 HOXA5
homeobox A5
chr1_-_152131703 0.478 ENST00000316073.3
 RPTN
repetin
chr17_-_38859996 0.430 ENST00000264651.2
 KRT24
keratin 24
chr8_-_133123406 0.394 ENST00000434736.2
 HHLA1
HERV-H LTR-associating 1
chrX_+_135279179 0.368 ENST00000370676.3
 FHL1
four and a half LIM domains 1
chr12_-_89746173 0.365 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr4_-_41884620 0.301 ENST00000504870.1
 LINC00682
long intergenic non-protein coding RNA 682
chrX_+_135251835 0.288 ENST00000456445.1
 FHL1
four and a half LIM domains 1
chrX_+_135251783 0.282 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chr4_-_41750922 0.267 ENST00000226382.2
 PHOX2B
paired-like homeobox 2b
chr7_-_27205136 0.253 ENST00000396345.1
ENST00000343483.6
 HOXA9

homeobox A9

chrX_+_135252050 0.252 ENST00000449474.1
ENST00000345434.3
 FHL1

four and a half LIM domains 1

chr12_-_13248598 0.236 ENST00000337630.6
ENST00000545699.1
 GSG1

germ cell associated 1

chr2_-_29297127 0.236 ENST00000331664.5
 C2orf71
chromosome 2 open reading frame 71
chr15_+_93443419 0.234 ENST00000557381.1
ENST00000420239.2
 CHD2

chromodomain helicase DNA binding protein 2

chr13_-_95131923 0.225 ENST00000377028.5
ENST00000446125.1
 DCT

dopachrome tautomerase

chr7_-_27142290 0.211 ENST00000222718.5
 HOXA2
homeobox A2
chr8_+_104831472 0.204 ENST00000262231.10
ENST00000507740.1
 RIMS2

regulating synaptic membrane exocytosis 2

chr2_-_177502659 0.202 ENST00000295549.4
 AC017048.3
long intergenic non-protein coding RNA 1116
chr7_+_107110488 0.180 ENST00000304402.4
 GPR22
G protein-coupled receptor 22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 0.7 GO:0060435 bronchiole development(GO:0060435)
0.1 0.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.3 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:0035283 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 0.2 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 0.2 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.2 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0035542 positive regulation of vesicle fusion(GO:0031340) regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.0 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.0 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation