Motif ID: HOXB13

Z-value: 0.424


Transcription factors associated with HOXB13:

Gene SymbolEntrez IDGene Name
HOXB13 ENSG00000159184.7 HOXB13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_46806558-0.067.8e-01Click!


Activity profile for motif HOXB13.

activity profile for motif HOXB13


Sorted Z-values histogram for motif HOXB13

Sorted Z-values for motif HOXB13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB13

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_86376081 2.028 ENST00000285379.5
 CA2
carbonic anhydrase II
chr1_+_84630645 1.179 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_125133315 1.148 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr2_-_190044480 1.039 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr11_-_102826434 1.029 ENST00000340273.4
ENST00000260302.3
 MMP13

matrix metallopeptidase 13 (collagenase 3)

chr17_-_39538550 0.748 ENST00000394001.1
 KRT34
keratin 34
chr1_+_84630053 0.686 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr5_+_135496675 0.669 ENST00000507637.1
 SMAD5
SMAD family member 5
chr6_+_122793058 0.654 ENST00000392491.2
 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr19_+_1440838 0.642 ENST00000594262.1
 AC027307.3
Uncharacterized protein
chr16_-_2205352 0.598 ENST00000563192.1
 RP11-304L19.5
RP11-304L19.5
chr5_-_145214893 0.545 ENST00000394450.2
 PRELID2
PRELI domain containing 2
chr9_+_125132803 0.502 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_-_50860565 0.438 ENST00000403097.1
 GRB10
growth factor receptor-bound protein 10
chr15_-_55541227 0.416 ENST00000566877.1
 RAB27A
RAB27A, member RAS oncogene family
chr1_-_45956800 0.399 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr19_+_35634146 0.392 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
 FXYD7


FXYD domain containing ion transport regulator 7


chr1_-_155880672 0.363 ENST00000609492.1
ENST00000368322.3
 RIT1

Ras-like without CAAX 1

chr7_+_35756092 0.360 ENST00000458087.3
 AC018647.3
AC018647.3
chrM_-_14670 0.353 ENST00000361681.2
 MT-ND6
mitochondrially encoded NADH dehydrogenase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0097338 response to clozapine(GO:0097338)
0.7 2.0 GO:0042938 dipeptide transport(GO:0042938)
0.1 1.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 1.0 GO:0003417 growth plate cartilage development(GO:0003417)
0.1 0.7 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.4 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.0 0.1 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.7 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:1990393 3M complex(GO:1990393)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 2.0 GO:0004064 arylesterase activity(GO:0004064)
0.4 1.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 0.8 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.0 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts