Motif ID: HOXB13

Z-value: 0.424


Transcription factors associated with HOXB13:

Gene SymbolEntrez IDGene Name
HOXB13 ENSG00000159184.7 HOXB13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_46806558-0.067.8e-01Click!


Activity profile for motif HOXB13.

activity profile for motif HOXB13


Sorted Z-values histogram for motif HOXB13

Sorted Z-values for motif HOXB13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_86376081 2.028 ENST00000285379.5
 CA2
carbonic anhydrase II
chr1_+_84630645 1.179 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_125133315 1.148 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr2_-_190044480 1.039 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr11_-_102826434 1.029 ENST00000340273.4
ENST00000260302.3
 MMP13

matrix metallopeptidase 13 (collagenase 3)

chr17_-_39538550 0.748 ENST00000394001.1
 KRT34
keratin 34
chr1_+_84630053 0.686 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr5_+_135496675 0.669 ENST00000507637.1
 SMAD5
SMAD family member 5
chr6_+_122793058 0.654 ENST00000392491.2
 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr19_+_1440838 0.642 ENST00000594262.1
 AC027307.3
Uncharacterized protein
chr16_-_2205352 0.598 ENST00000563192.1
 RP11-304L19.5
RP11-304L19.5
chr5_-_145214893 0.545 ENST00000394450.2
 PRELID2
PRELI domain containing 2
chr9_+_125132803 0.502 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_-_50860565 0.438 ENST00000403097.1
 GRB10
growth factor receptor-bound protein 10
chr15_-_55541227 0.416 ENST00000566877.1
 RAB27A
RAB27A, member RAS oncogene family
chr1_-_45956800 0.399 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr19_+_35634146 0.392 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
 FXYD7


FXYD domain containing ion transport regulator 7


chr1_-_155880672 0.363 ENST00000609492.1
ENST00000368322.3
 RIT1

Ras-like without CAAX 1

chr7_+_35756092 0.360 ENST00000458087.3
 AC018647.3
AC018647.3
chrM_-_14670 0.353 ENST00000361681.2
 MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr19_+_56154913 0.319 ENST00000270451.5
ENST00000588537.1
 ZNF581

zinc finger protein 581

chr14_+_76776957 0.318 ENST00000512784.1
 ESRRB
estrogen-related receptor beta
chr14_-_72458326 0.295 ENST00000542853.1
 AC005477.1
AC005477.1
chr7_+_132937820 0.288 ENST00000393161.2
ENST00000253861.4
 EXOC4

exocyst complex component 4

chr11_+_63606373 0.270 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
 MARK2




MAP/microtubule affinity-regulating kinase 2




chr8_+_97597148 0.265 ENST00000521590.1
 SDC2
syndecan 2
chr6_-_27782548 0.252 ENST00000333151.3
 HIST1H2AJ
histone cluster 1, H2aj
chr5_-_145214848 0.230 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
 PRELID2



PRELI domain containing 2



chr13_-_103719196 0.229 ENST00000245312.3
 SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr1_+_84630367 0.220 ENST00000370680.1
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_-_80926457 0.219 ENST00000563626.1
ENST00000562231.1
 RP11-314O13.1

RP11-314O13.1

chr4_-_69111401 0.185 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr1_-_45956822 0.183 ENST00000372086.3
ENST00000341771.6
 TESK2

testis-specific kinase 2

chr17_-_73663168 0.182 ENST00000578201.1
ENST00000423245.2
 RECQL5

RecQ protein-like 5

chr13_-_45768841 0.174 ENST00000379108.1
 KCTD4
potassium channel tetramerization domain containing 4
chr6_-_43021612 0.173 ENST00000535468.1
 CUL7
cullin 7
chrX_+_115301975 0.169 ENST00000371906.4
 AGTR2
angiotensin II receptor, type 2
chr12_-_52715179 0.164 ENST00000293670.3
 KRT83
keratin 83
chr19_+_48497962 0.156 ENST00000596043.1
ENST00000597519.1
 ELSPBP1

epididymal sperm binding protein 1

chr3_+_68053359 0.155 ENST00000478136.1
 FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr1_+_23037323 0.150 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
 EPHB2



EPH receptor B2



chr12_+_8309630 0.142 ENST00000396570.3
 ZNF705A
zinc finger protein 705A
chr19_+_48497901 0.141 ENST00000339841.2
 ELSPBP1
epididymal sperm binding protein 1
chr6_+_27782788 0.138 ENST00000359465.4
 HIST1H2BM
histone cluster 1, H2bm
chr1_-_149783914 0.133 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
 HIST2H2BF


histone cluster 2, H2bf


chr1_+_52682052 0.130 ENST00000371591.1
 ZFYVE9
zinc finger, FYVE domain containing 9
chr14_-_51027838 0.125 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_+_77593448 0.117 ENST00000521891.2
 ZFHX4
zinc finger homeobox 4
chr5_-_126409159 0.115 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
 C5orf63



chromosome 5 open reading frame 63



chr3_-_150690786 0.107 ENST00000327047.1
 CLRN1
clarin 1
chr15_+_71839566 0.103 ENST00000357769.4
 THSD4
thrombospondin, type I, domain containing 4
chr4_-_164534657 0.103 ENST00000339875.5
 MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr8_+_77593474 0.101 ENST00000455469.2
ENST00000050961.6
 ZFHX4

zinc finger homeobox 4

chr16_+_30669720 0.099 ENST00000356166.6
 FBRS
fibrosin
chr16_-_71610985 0.098 ENST00000355962.4
 TAT
tyrosine aminotransferase
chr6_-_116833500 0.096 ENST00000356128.4
 TRAPPC3L
trafficking protein particle complex 3-like
chr17_-_39646116 0.081 ENST00000328119.6
 KRT36
keratin 36
chr2_+_67624430 0.079 ENST00000272342.5
 ETAA1
Ewing tumor-associated antigen 1
chr19_-_5903714 0.070 ENST00000252675.5
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000586349.1
ENST00000585661.1
 FUT5
NDUFA11


AC024592.12

fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa


Uncharacterized protein

chr1_+_110993795 0.059 ENST00000271331.3
 PROK1
prokineticin 1
chr2_-_175629164 0.054 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
 CHRNA1


cholinergic receptor, nicotinic, alpha 1 (muscle)


chr16_+_2205755 0.053 ENST00000326181.6
 TRAF7
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
chr3_+_89156674 0.043 ENST00000336596.2
 EPHA3
EPH receptor A3
chr16_-_24942273 0.035 ENST00000571406.1
 ARHGAP17
Rho GTPase activating protein 17
chr12_+_70219052 0.033 ENST00000552032.2
ENST00000547771.2
 MYRFL

myelin regulatory factor-like

chr17_-_73663245 0.029 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
 RECQL5



RecQ protein-like 5



chr4_+_68424434 0.028 ENST00000265404.2
ENST00000396225.1
 STAP1

signal transducing adaptor family member 1

chr11_+_118401706 0.026 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
 TMEM25


transmembrane protein 25


chr1_-_151148492 0.023 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr2_-_175629135 0.023 ENST00000409542.1
ENST00000409219.1
 CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr1_+_66458072 0.021 ENST00000423207.2
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr16_-_24942411 0.019 ENST00000571843.1
 ARHGAP17
Rho GTPase activating protein 17
chr13_+_28813645 0.018 ENST00000282391.5
 PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_-_14180778 0.011 ENST00000380924.1
ENST00000543693.1
 NFIB

nuclear factor I/B

chr2_-_136288113 0.003 ENST00000401392.1
 ZRANB3
zinc finger, RAN-binding domain containing 3
chr4_+_110749143 0.002 ENST00000317735.4
 RRH
retinal pigment epithelium-derived rhodopsin homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0042938 dipeptide transport(GO:0042938)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 2.1 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 1.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 1.0 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.4 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.1 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.7 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 2.0 GO:0004064 arylesterase activity(GO:0004064)
0.2 0.8 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 2.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts