Motif ID: HOXB2_UNCX_HOXD3

Z-value: 0.511

Transcription factors associated with HOXB2_UNCX_HOXD3:

Gene SymbolEntrez IDGene Name
HOXB2 ENSG00000173917.9 HOXB2
HOXD3 ENSG00000128652.7 HOXD3
UNCX ENSG00000164853.8 UNCX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD3hg19_v2_chr2_+_177015122_1770151220.125.7e-01Click!
HOXB2hg19_v2_chr17_-_46623441_46623441-0.029.2e-01Click!


Activity profile for motif HOXB2_UNCX_HOXD3.

activity profile for motif HOXB2_UNCX_HOXD3


Sorted Z-values histogram for motif HOXB2_UNCX_HOXD3

Sorted Z-values for motif HOXB2_UNCX_HOXD3



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB2_UNCX_HOXD3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_141747950 1.346 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_217804661 0.964 ENST00000366933.4
 SPATA17
spermatogenesis associated 17
chr12_+_7013897 0.926 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 0.904 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr1_-_47407097 0.884 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr8_-_10512569 0.873 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr5_+_68860949 0.863 ENST00000507595.1
 GTF2H2C
general transcription factor IIH, polypeptide 2C
chr20_-_7921090 0.820 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_76072719 0.771 ENST00000370020.1
 FILIP1
filamin A interacting protein 1
chrX_-_13835147 0.763 ENST00000493677.1
ENST00000355135.2
 GPM6B

glycoprotein M6B

chr8_+_94241867 0.745 ENST00000598428.1
 AC016885.1
Uncharacterized protein
chr17_-_39306054 0.724 ENST00000343246.4
 KRTAP4-5
keratin associated protein 4-5
chr6_-_49681235 0.679 ENST00000339139.4
 CRISP2
cysteine-rich secretory protein 2
chr16_+_53133070 0.645 ENST00000565832.1
 CHD9
chromodomain helicase DNA binding protein 9
chr17_-_33446735 0.571 ENST00000460118.2
ENST00000335858.7
 RAD51D

RAD51 paralog D

chr1_-_48937838 0.567 ENST00000371847.3
 SPATA6
spermatogenesis associated 6
chr10_-_28270795 0.566 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr4_-_105416039 0.555 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr1_+_109256067 0.538 ENST00000271311.2
 FNDC7
fibronectin type III domain containing 7
chr9_-_95166884 0.514 ENST00000375561.5
 OGN
osteoglycin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.5 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 0.9 GO:0003095 pressure natriuresis(GO:0003095)
0.1 0.9 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.9 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.1 0.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.7 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.6 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.6 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.5 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0 0.5 GO:0015671 oxygen transport(GO:0015671)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.5 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 1.0 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.9 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 0.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.6 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.9 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.3 0.8 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.8 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.5 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.5 GO:0043394 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.4 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.4 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.1 0.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection