Motif ID: HOXB3

Z-value: 0.612


Transcription factors associated with HOXB3:

Gene SymbolEntrez IDGene Name
HOXB3 ENSG00000120093.7 HOXB3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB3hg19_v2_chr17_-_46667594_466676190.582.9e-03Click!


Activity profile for motif HOXB3.

activity profile for motif HOXB3


Sorted Z-values histogram for motif HOXB3

Sorted Z-values for motif HOXB3



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_152486950 2.314 ENST00000368790.3
 CRCT1
cysteine-rich C-terminal 1
chr17_+_62223320 1.543 ENST00000580828.1
ENST00000582965.1
 SNORA76

small nucleolar RNA, H/ACA box 76

chr22_+_30792980 1.153 ENST00000403484.1
ENST00000405717.3
ENST00000402592.3
 SEC14L2


SEC14-like 2 (S. cerevisiae)


chr11_-_107729887 1.052 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr4_+_86525299 1.048 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr12_+_15699286 1.041 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr5_+_150639360 1.015 ENST00000523004.1
 GM2A
GM2 ganglioside activator
chr1_+_62439037 0.948 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr17_-_9683238 0.929 ENST00000571771.1
 DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr2_+_113816215 0.915 ENST00000346807.3
 IL36RN
interleukin 36 receptor antagonist
chr6_+_34204642 0.907 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1




high mobility group AT-hook 1




chr3_+_121774202 0.881 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86



CD86 molecule



chr2_+_113816685 0.811 ENST00000393200.2
 IL36RN
interleukin 36 receptor antagonist
chr17_+_40610862 0.809 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
 ATP6V0A1








ATPase, H+ transporting, lysosomal V0 subunit a1








chr4_+_144354644 0.793 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr11_+_33061543 0.780 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1


t-complex 11, testis-specific-like 1


chr12_-_123187890 0.777 ENST00000328880.5
 HCAR2
hydroxycarboxylic acid receptor 2
chr2_+_28618532 0.776 ENST00000545753.1
 FOSL2
FOS-like antigen 2
chr12_-_123201337 0.728 ENST00000528880.2
 HCAR3
hydroxycarboxylic acid receptor 3
chr4_-_69111401 0.727 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 1.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.4 1.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 1.0 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 1.0 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.3 0.9 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 0.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.9 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.2 0.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.8 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 0.7 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.2 0.7 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 0.7 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.7 GO:1903575 cornified envelope assembly(GO:1903575)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 1.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 0.8 GO:1990923 PET complex(GO:1990923)
0.1 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.7 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 0.5 GO:1990032 parallel fiber(GO:1990032)
0.1 0.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.5 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 1.2 GO:0008431 vitamin E binding(GO:0008431)
0.1 1.0 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 0.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.9 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.2 0.8 GO:0034584 piRNA binding(GO:0034584)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 0.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 0.7 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.7 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.7 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.6 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.5 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.5 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.9 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.9 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle