Motif ID: HOXB4_LHX9
Z-value: 0.825
Transcription factors associated with HOXB4_LHX9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HOXB4 | ENSG00000182742.5 | HOXB4 |
| LHX9 | ENSG00000143355.11 | LHX9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX9 | hg19_v2_chr1_+_197881592_197881635 | 0.44 | 3.1e-02 | Click! |
| HOXB4 | hg19_v2_chr17_-_46657473_46657473 | 0.43 | 3.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 138 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 5.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 4.7 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.2 | 4.0 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 3.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 2.6 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 2.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.4 | 2.2 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 2.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.0 | 2.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 1.9 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.0 | 1.9 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.1 | 1.7 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 1.7 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 1.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 1.6 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.1 | 1.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 1.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.3 | 1.3 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.2 | 1.3 | GO:0030035 | microspike assembly(GO:0030035) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 68 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.0 | 4.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 3.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 3.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 2.6 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.2 | 2.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 2.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 2.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 1.7 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 1.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.7 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 1.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.4 | 1.2 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.2 | 1.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.2 | 1.2 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.1 | 1.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 1.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.4 | 1.1 | GO:1990032 | parallel fiber(GO:1990032) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 96 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 4.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.9 | 3.6 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.0 | 3.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.9 | 2.6 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 2.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 2.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 2.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 2.0 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 1.9 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 1.9 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 1.7 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 1.6 | GO:0005549 | odorant binding(GO:0005549) |
| 0.2 | 1.4 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 1.4 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.1 | 1.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 1.2 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.2 | 1.2 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 3.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.5 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.4 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 2.1 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.3 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.2 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.1 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.9 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.8 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.8 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.7 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.5 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.4 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.3 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 49 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 4.2 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 3.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.0 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.4 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.2 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.9 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 1.6 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.3 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 1.2 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.2 | REACTOME_INWARDLY_RECTIFYING_K_CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 1.1 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 1.1 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.0 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 1.0 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 0.9 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.9 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
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