Motif ID: HOXB5

Z-value: 0.612


Transcription factors associated with HOXB5:

Gene SymbolEntrez IDGene Name
HOXB5 ENSG00000120075.5 HOXB5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.377.5e-02Click!


Activity profile for motif HOXB5.

activity profile for motif HOXB5


Sorted Z-values histogram for motif HOXB5

Sorted Z-values for motif HOXB5



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_133097902 3.819 ENST00000262283.5
 OC90
Otoconin-90
chr19_-_16045220 2.215 ENST00000326742.8
 CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr17_+_46970134 0.627 ENST00000503641.1
ENST00000514808.1
 ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr19_-_50143452 0.626 ENST00000246792.3
 RRAS
related RAS viral (r-ras) oncogene homolog
chr17_+_46970178 0.616 ENST00000393366.2
ENST00000506855.1
 ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr17_+_46970127 0.574 ENST00000355938.5
 ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_+_56915776 0.509 ENST00000550726.1
ENST00000542360.1
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr16_-_84651647 0.499 ENST00000564057.1
 COTL1
coactosin-like 1 (Dictyostelium)
chr10_-_103603523 0.473 ENST00000370046.1
 KCNIP2
Kv channel interacting protein 2
chr12_+_66217911 0.448 ENST00000403681.2
 HMGA2
high mobility group AT-hook 2
chr12_+_56915713 0.437 ENST00000262031.5
ENST00000552247.2
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr3_-_195538760 0.405 ENST00000475231.1
 MUC4
mucin 4, cell surface associated
chr1_+_4714792 0.369 ENST00000378190.3
 AJAP1
adherens junctions associated protein 1
chr11_-_125648690 0.365 ENST00000436890.2
ENST00000358524.3
 PATE2

prostate and testis expressed 2

chr16_+_31539197 0.314 ENST00000564707.1
 AHSP
alpha hemoglobin stabilizing protein
chr3_-_195538728 0.312 ENST00000349607.4
ENST00000346145.4
 MUC4

mucin 4, cell surface associated

chr7_+_5322561 0.300 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
 SLC29A4



solute carrier family 29 (equilibrative nucleoside transporter), member 4



chr6_+_121756809 0.300 ENST00000282561.3
 GJA1
gap junction protein, alpha 1, 43kDa
chrX_+_135230712 0.294 ENST00000535737.1
 FHL1
four and a half LIM domains 1
chrX_+_47077632 0.277 ENST00000457458.2
 CDK16
cyclin-dependent kinase 16
chr6_-_29395509 0.275 ENST00000377147.2
 OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr3_-_127541194 0.257 ENST00000453507.2
 MGLL
monoglyceride lipase
chr1_-_161193349 0.254 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
 APOA2






apolipoprotein A-II






chr1_+_155579979 0.253 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
 MSTO1



misato 1, mitochondrial distribution and morphology regulator



chr6_-_29396243 0.251 ENST00000377148.1
 OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr7_-_102252038 0.246 ENST00000461209.1
 RASA4
RAS p21 protein activator 4
chr3_-_164914640 0.237 ENST00000241274.3
 SLITRK3
SLIT and NTRK-like family, member 3
chr15_+_74218787 0.237 ENST00000261921.7
 LOXL1
lysyl oxidase-like 1
chr2_-_47168850 0.229 ENST00000409207.1
 MCFD2
multiple coagulation factor deficiency 2
chr3_-_128186091 0.225 ENST00000319153.3
 DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr6_-_97285336 0.222 ENST00000229955.3
ENST00000417980.1
 GPR63

G protein-coupled receptor 63

chrM_+_12331 0.222 ENST00000361567.2
 MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr3_+_51422478 0.215 ENST00000528157.1
 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr2_-_47168906 0.207 ENST00000444761.2
ENST00000409147.1
 MCFD2

multiple coagulation factor deficiency 2

chr10_-_103603568 0.192 ENST00000356640.2
 KCNIP2
Kv channel interacting protein 2
chr17_-_17140436 0.188 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
 FLCN


folliculin


chr12_-_53614155 0.184 ENST00000543726.1
 RARG
retinoic acid receptor, gamma
chr15_-_75017711 0.179 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
 CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1





chr12_-_52715179 0.173 ENST00000293670.3
 KRT83
keratin 83
chr1_+_154975110 0.171 ENST00000535420.1
ENST00000368426.3
 ZBTB7B

zinc finger and BTB domain containing 7B

chr12_-_53614043 0.162 ENST00000338561.5
 RARG
retinoic acid receptor, gamma
chr16_-_58004992 0.159 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
 CNGB1


cyclic nucleotide gated channel beta 1


chr2_+_17721920 0.153 ENST00000295156.4
 VSNL1
visinin-like 1
chrX_-_139587225 0.147 ENST00000370536.2
 SOX3
SRY (sex determining region Y)-box 3
chr6_-_31869769 0.140 ENST00000375527.2
 ZBTB12
zinc finger and BTB domain containing 12
chr3_+_45986511 0.133 ENST00000458629.1
ENST00000457814.1
 CXCR6

chemokine (C-X-C motif) receptor 6

chr11_-_57089671 0.132 ENST00000532437.1
 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr13_-_64650144 0.129 ENST00000456627.1
 LINC00355
long intergenic non-protein coding RNA 355
chr1_+_41157421 0.122 ENST00000372654.1
 NFYC
nuclear transcription factor Y, gamma
chr17_+_6679528 0.121 ENST00000321535.4
 FBXO39
F-box protein 39
chr17_-_42143963 0.116 ENST00000585388.1
ENST00000293406.3
 LSM12

LSM12 homolog (S. cerevisiae)

chr1_+_162351503 0.114 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr1_+_116915855 0.114 ENST00000295598.5
 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_+_167525277 0.113 ENST00000400926.2
 CCR6
chemokine (C-C motif) receptor 6
chr18_-_33077556 0.108 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr1_+_206317450 0.104 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
 CTSE


cathepsin E


chr6_-_32820529 0.103 ENST00000425148.2
 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_-_30102547 0.098 ENST00000279386.2
 TBX6
T-box 6
chr14_+_21945335 0.098 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
 TOX4


TOX high mobility group box family member 4


chrX_+_48380205 0.093 ENST00000446158.1
ENST00000414061.1
 EBP

emopamil binding protein (sterol isomerase)

chr7_+_120969045 0.091 ENST00000222462.2
 WNT16
wingless-type MMTV integration site family, member 16
chr9_+_4662282 0.091 ENST00000381883.2
 PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr11_-_35440579 0.090 ENST00000606205.1
 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr13_-_54706954 0.086 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
 LINC00458




long intergenic non-protein coding RNA 458




chr17_+_2496971 0.081 ENST00000397195.5
 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_149569520 0.081 ENST00000230671.2
ENST00000524041.1
 SLC6A7

solute carrier family 6 (neurotransmitter transporter), member 7

chr1_+_146373546 0.078 ENST00000446760.2
 NBPF12
neuroblastoma breakpoint family, member 12
chr20_-_3687775 0.077 ENST00000344754.4
ENST00000202578.4
 SIGLEC1

sialic acid binding Ig-like lectin 1, sialoadhesin

chr1_+_41157361 0.072 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
 NFYC




nuclear transcription factor Y, gamma




chr20_-_6034672 0.067 ENST00000378858.4
 LRRN4
leucine rich repeat neuronal 4
chr7_+_130020932 0.067 ENST00000484324.1
 CPA1
carboxypeptidase A1 (pancreatic)
chr12_-_56101647 0.066 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
 ITGA7




integrin, alpha 7




chr12_+_53693466 0.052 ENST00000267103.5
ENST00000548632.1
 C12orf10

chromosome 12 open reading frame 10

chr8_+_118147498 0.048 ENST00000519688.1
ENST00000456015.2
 SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr16_-_30381580 0.046 ENST00000409939.3
 TBC1D10B
TBC1 domain family, member 10B
chr15_-_49103235 0.043 ENST00000380950.2
 CEP152
centrosomal protein 152kDa
chr8_-_93107443 0.043 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
 RUNX1T1







runt-related transcription factor 1; translocated to, 1 (cyclin D-related)







chr1_-_119530428 0.034 ENST00000369429.3
 TBX15
T-box 15
chr2_-_188430478 0.029 ENST00000421427.1
 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_-_31509714 0.027 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
 DDX39B









DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B









chr1_-_155658518 0.024 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
 YY1AP1


YY1 associated protein 1


chrX_+_103411189 0.019 ENST00000493442.1
 FAM199X
family with sequence similarity 199, X-linked
chr19_+_7571968 0.018 ENST00000599312.1
 CTD-2207O23.12
Uncharacterized protein
chr1_-_155658766 0.014 ENST00000295566.4
ENST00000368330.2
 YY1AP1

YY1 associated protein 1

chr4_-_68620053 0.013 ENST00000420975.2
ENST00000226413.4
 GNRHR

gonadotropin-releasing hormone receptor

chr5_-_35048047 0.010 ENST00000231420.6
 AGXT2
alanine--glyoxylate aminotransferase 2
chr1_-_155658260 0.006 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
 YY1AP1







YY1 associated protein 1







chr8_-_93107827 0.003 ENST00000520724.1
ENST00000518844.1
 RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr3_+_130613226 0.003 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
 ATP2C1




ATPase, Ca++ transporting, type 2C, member 1




chr20_-_48184638 0.002 ENST00000244043.4
 PTGIS
prostaglandin I2 (prostacyclin) synthase
chr19_-_12267524 0.001 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
 ZNF625



zinc finger protein 625



chr6_-_31510181 0.001 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
 DDX39B


DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1 0.4 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.4 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.3 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 3.8 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.3 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.1 1.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:2001170 negative regulation of energy homeostasis(GO:2000506) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.1 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:0046469 platelet activating factor metabolic process(GO:0046469)
0.0 0.1 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.3 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.4 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 3.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 2.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.3 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.3 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation