Motif ID: HOXB5

Z-value: 0.612


Transcription factors associated with HOXB5:

Gene SymbolEntrez IDGene Name
HOXB5 ENSG00000120075.5 HOXB5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.377.5e-02Click!


Activity profile for motif HOXB5.

activity profile for motif HOXB5


Sorted Z-values histogram for motif HOXB5

Sorted Z-values for motif HOXB5



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB5

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_133097902 3.819 ENST00000262283.5
 OC90
Otoconin-90
chr19_-_16045220 2.215 ENST00000326742.8
 CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr17_+_46970134 0.627 ENST00000503641.1
ENST00000514808.1
 ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr19_-_50143452 0.626 ENST00000246792.3
 RRAS
related RAS viral (r-ras) oncogene homolog
chr17_+_46970178 0.616 ENST00000393366.2
ENST00000506855.1
 ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr17_+_46970127 0.574 ENST00000355938.5
 ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_+_56915776 0.509 ENST00000550726.1
ENST00000542360.1
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr16_-_84651647 0.499 ENST00000564057.1
 COTL1
coactosin-like 1 (Dictyostelium)
chr10_-_103603523 0.473 ENST00000370046.1
 KCNIP2
Kv channel interacting protein 2
chr12_+_66217911 0.448 ENST00000403681.2
 HMGA2
high mobility group AT-hook 2
chr12_+_56915713 0.437 ENST00000262031.5
ENST00000552247.2
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr3_-_195538760 0.405 ENST00000475231.1
 MUC4
mucin 4, cell surface associated
chr1_+_4714792 0.369 ENST00000378190.3
 AJAP1
adherens junctions associated protein 1
chr11_-_125648690 0.365 ENST00000436890.2
ENST00000358524.3
 PATE2

prostate and testis expressed 2

chr16_+_31539197 0.314 ENST00000564707.1
 AHSP
alpha hemoglobin stabilizing protein
chr3_-_195538728 0.312 ENST00000349607.4
ENST00000346145.4
 MUC4

mucin 4, cell surface associated

chr7_+_5322561 0.300 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
 SLC29A4



solute carrier family 29 (equilibrative nucleoside transporter), member 4



chr6_+_121756809 0.300 ENST00000282561.3
 GJA1
gap junction protein, alpha 1, 43kDa
chrX_+_135230712 0.294 ENST00000535737.1
 FHL1
four and a half LIM domains 1
chrX_+_47077632 0.277 ENST00000457458.2
 CDK16
cyclin-dependent kinase 16

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.6 2.2 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1 1.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)
0.1 0.4 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.4 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.3 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.3 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.3 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.3 GO:0048311 mitochondrion distribution(GO:0048311)
0.1 0.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.0 0.2 GO:2001170 negative regulation of energy homeostasis(GO:2000506) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:0020027 hemoglobin metabolic process(GO:0020027)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 2.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.7 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.3 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.3 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.1 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation