Motif ID: HOXB6_PRRX2

Z-value: 0.905

Transcription factors associated with HOXB6_PRRX2:

Gene SymbolEntrez IDGene Name
HOXB6 ENSG00000108511.8 HOXB6
PRRX2 ENSG00000167157.9 PRRX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRRX2hg19_v2_chr9_+_132427883_132427951-0.232.8e-01Click!
HOXB6hg19_v2_chr17_-_46682321_466823620.067.7e-01Click!


Activity profile for motif HOXB6_PRRX2.

activity profile for motif HOXB6_PRRX2


Sorted Z-values histogram for motif HOXB6_PRRX2

Sorted Z-values for motif HOXB6_PRRX2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB6_PRRX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_135251783 2.611 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chrX_+_135252050 2.423 ENST00000449474.1
ENST00000345434.3
 FHL1

four and a half LIM domains 1

chrX_+_135251835 2.353 ENST00000456445.1
 FHL1
four and a half LIM domains 1
chr1_+_50569575 2.160 ENST00000371827.1
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chrX_+_135279179 2.097 ENST00000370676.3
 FHL1
four and a half LIM domains 1
chr2_-_161056762 1.949 ENST00000428609.2
ENST00000409967.2
 ITGB6

integrin, beta 6

chr5_-_88119580 1.929 ENST00000539796.1
 MEF2C
myocyte enhancer factor 2C
chr12_-_122240792 1.844 ENST00000541657.1
ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
 RHOF
AC084018.1





ras homolog family member F (in filopodia)
AC084018.1





chr12_-_89746173 1.836 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr2_-_216257849 1.728 ENST00000456923.1
 FN1
fibronectin 1
chr12_+_4385230 1.722 ENST00000536537.1
 CCND2
cyclin D2
chr2_+_54785485 1.686 ENST00000333896.5
 SPTBN1
spectrin, beta, non-erythrocytic 1
chr17_-_39211463 1.496 ENST00000542910.1
ENST00000398477.1
 KRTAP2-2

keratin associated protein 2-2

chr7_-_41742697 1.449 ENST00000242208.4
 INHBA
inhibin, beta A
chr6_+_130339710 1.405 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chrX_+_135278908 1.403 ENST00000539015.1
ENST00000370683.1
 FHL1

four and a half LIM domains 1

chr4_-_41750922 1.363 ENST00000226382.2
 PHOX2B
paired-like homeobox 2b
chr3_-_74570291 1.342 ENST00000263665.6
 CNTN3
contactin 3 (plasmacytoma associated)
chr14_-_57272366 1.292 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
 OTX2


orthodenticle homeobox 2


chr2_+_191792376 1.236 ENST00000409428.1
ENST00000409215.1
 GLS

glutaminase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 4.3 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 3.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.3 3.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 2.3 GO:0048813 dendrite morphogenesis(GO:0048813)
0.1 2.2 GO:0002076 osteoblast development(GO:0002076)
0.5 2.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.3 2.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.5 2.0 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.3 1.9 GO:0097338 response to clozapine(GO:0097338)
0.6 1.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.6 1.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 1.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.3 1.6 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 1.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.5 1.4 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.5 1.4 GO:0003358 noradrenergic neuron development(GO:0003358)
0.2 1.4 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 1.4 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.2 GO:0005925 focal adhesion(GO:0005925)
0.0 4.3 GO:0072562 blood microparticle(GO:0072562)
1.0 3.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.8 GO:0030478 actin cap(GO:0030478)
0.2 2.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.6 GO:0045095 keratin filament(GO:0045095)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)
0.1 2.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 2.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 2.1 GO:0032437 cuticular plate(GO:0032437)
0.1 2.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 1.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 1.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.5 1.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 1.3 GO:0043219 lateral loop(GO:0043219)
0.0 1.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.3 GO:0005796 Golgi lumen(GO:0005796)
0.3 1.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0044325 ion channel binding(GO:0044325)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.1 3.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 3.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 3.1 GO:0001618 virus receptor activity(GO:0001618)
0.2 2.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.7 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 2.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 2.1 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 1.7 GO:0050436 microfibril binding(GO:0050436)
0.0 1.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 1.4 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.9 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 2.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.7 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 1.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.3 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis