Motif ID: HOXB8

Z-value: 0.791


Transcription factors associated with HOXB8:

Gene SymbolEntrez IDGene Name
HOXB8 ENSG00000120068.5 HOXB8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB8hg19_v2_chr17_-_46691990_46692066,
hg19_v2_chr17_-_46690839_46690884		0.106.5e-01Click!


Activity profile for motif HOXB8.

activity profile for motif HOXB8


Sorted Z-values histogram for motif HOXB8

Sorted Z-values for motif HOXB8



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_8975061 1.728 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr15_-_80263506 1.620 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr4_+_75230853 1.540 ENST00000244869.2
 EREG
epiregulin
chr16_-_46655538 1.529 ENST00000303383.3
 SHCBP1
SHC SH2-domain binding protein 1
chr7_+_134528635 1.465 ENST00000445569.2
 CALD1
caldesmon 1
chr1_-_205391178 1.296 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr20_-_1309809 1.241 ENST00000360779.3
 SDCBP2
syndecan binding protein (syntenin) 2
chr3_+_100354442 1.221 ENST00000475887.1
 GPR128
G protein-coupled receptor 128
chr12_-_95510743 1.179 ENST00000551521.1
 FGD6
FYVE, RhoGEF and PH domain containing 6
chr1_-_200589859 1.169 ENST00000367350.4
 KIF14
kinesin family member 14
chr15_-_74501360 1.138 ENST00000323940.5
 STRA6
stimulated by retinoic acid 6
chr6_+_130339710 1.127 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr2_-_161056762 1.102 ENST00000428609.2
ENST00000409967.2
 ITGB6

integrin, beta 6

chr4_+_144354644 1.088 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr6_-_150346607 1.062 ENST00000367341.1
ENST00000286380.2
 RAET1L

retinoic acid early transcript 1L

chr2_-_89630186 1.047 ENST00000390264.2
 IGKV2-40
immunoglobulin kappa variable 2-40
chr6_-_131321863 1.027 ENST00000528282.1
 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_+_134430212 0.992 ENST00000436461.2
 CALD1
caldesmon 1
chr1_+_87012753 0.965 ENST00000370563.3
 CLCA4
chloride channel accessory 4
chr14_+_35591858 0.959 ENST00000603544.1
 KIAA0391
KIAA0391

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 278 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.2 1.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 1.7 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 1.7 GO:0002076 osteoblast development(GO:0002076)
0.1 1.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 1.5 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.1 1.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 1.5 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 1.5 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 1.4 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 1.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 1.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 1.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 1.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.2 1.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.1 GO:0035728 response to hepatocyte growth factor(GO:0035728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0001726 ruffle(GO:0001726)
0.2 2.5 GO:0030478 actin cap(GO:0030478)
0.7 2.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.3 1.7 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 1.7 GO:0051233 spindle midzone(GO:0051233)
0.1 1.5 GO:0008091 spectrin(GO:0008091)
0.2 1.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.1 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 1.1 GO:0031430 M band(GO:0031430)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 0.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.1 1.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.9 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 1.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.6 GO:0051400 BH domain binding(GO:0051400)
0.1 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.3 1.3 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.2 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.3 1.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.0 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.7 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.1 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.3 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors