Motif ID: HOXC10_HOXD13

Z-value: 1.219

Transcription factors associated with HOXC10_HOXD13:

Gene SymbolEntrez IDGene Name
HOXC10 ENSG00000180818.4 HOXC10
HOXD13 ENSG00000128714.5 HOXD13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD13hg19_v2_chr2_+_176957619_1769576190.843.4e-07Click!
HOXC10hg19_v2_chr12_+_54378923_54378970-0.232.7e-01Click!


Activity profile for motif HOXC10_HOXD13.

activity profile for motif HOXC10_HOXD13


Sorted Z-values histogram for motif HOXC10_HOXD13

Sorted Z-values for motif HOXC10_HOXD13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC10_HOXD13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 7.100 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr12_-_52779433 6.808 ENST00000257951.3
 KRT84
keratin 84
chr5_+_7654057 6.499 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr1_+_84630645 5.408 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_116654376 4.675 ENST00000369500.3
 MAB21L3
mab-21-like 3 (C. elegans)
chr2_-_190044480 4.488 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr1_-_152386732 4.329 ENST00000271835.3
 CRNN
cornulin
chr20_+_37554955 3.500 ENST00000217429.4
 FAM83D
family with sequence similarity 83, member D
chr7_+_134464376 3.460 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chr2_-_216878305 3.246 ENST00000263268.6
 MREG
melanoregulin
chr1_+_152957707 2.944 ENST00000368762.1
 SPRR1A
small proline-rich protein 1A
chr7_+_134464414 2.907 ENST00000361901.2
 CALD1
caldesmon 1
chr7_-_41742697 2.821 ENST00000242208.4
 INHBA
inhibin, beta A
chr4_-_69111401 2.768 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr17_-_39553844 2.762 ENST00000251645.2
 KRT31
keratin 31
chr4_+_69313145 2.744 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr4_+_169013666 2.658 ENST00000359299.3
 ANXA10
annexin A10
chr8_-_49834299 2.504 ENST00000396822.1
 SNAI2
snail family zinc finger 2
chr9_+_105757590 2.489 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chrX_-_73072534 2.399 ENST00000429829.1
 XIST
X inactive specific transcript (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0070268 cornification(GO:0070268)
0.0 8.4 GO:0006936 muscle contraction(GO:0006936)
1.1 7.7 GO:0097338 response to clozapine(GO:0097338)
2.4 7.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.5 6.8 GO:0035878 nail development(GO:0035878)
0.5 6.5 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 6.1 GO:0010107 potassium ion import(GO:0010107)
1.5 4.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 3.6 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 3.4 GO:0016197 endosomal transport(GO:0016197)
0.1 3.3 GO:0032402 melanosome transport(GO:0032402)
0.1 3.3 GO:1902808 positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.5 3.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.9 2.8 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.4 2.7 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 2.7 GO:0030574 collagen catabolic process(GO:0030574)
0.8 2.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 2.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.3 2.4 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 2.3 GO:0019371 cyclooxygenase pathway(GO:0019371)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.9 GO:0005882 intermediate filament(GO:0005882)
0.8 12.2 GO:0030478 actin cap(GO:0030478)
0.4 7.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 7.3 GO:0005577 fibrinogen complex(GO:0005577)
0.2 6.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.5 4.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 4.5 GO:0001533 cornified envelope(GO:0001533)
0.1 3.7 GO:0030673 axolemma(GO:0030673)
0.3 3.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 3.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 3.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.4 GO:0035579 specific granule membrane(GO:0035579)
0.1 3.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.1 GO:0000786 nucleosome(GO:0000786)
0.1 2.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.9 2.8 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.7 2.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 2.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.8 2.5 GO:0033150 cytoskeletal calyx(GO:0033150)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.8 GO:0005523 tropomyosin binding(GO:0005523)
0.7 11.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.4 7.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 7.1 GO:0016504 peptidase activator activity(GO:0016504)
0.4 6.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 6.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 4.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.0 GO:0043236 laminin binding(GO:0043236)
0.0 3.8 GO:0030674 protein binding, bridging(GO:0030674)
0.6 3.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 3.5 GO:0019894 kinesin binding(GO:0019894)
0.0 3.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.9 GO:0051400 BH domain binding(GO:0051400)
0.9 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 2.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 2.6 GO:0002162 dystroglycan binding(GO:0002162)
0.2 2.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 12.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.9 NABA_COLLAGENS Genes encoding collagen proteins
0.2 7.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 6.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 3.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.5 PID_BCR_5PATHWAY BCR signaling pathway
0.1 2.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 7.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 7.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 7.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 7.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 6.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 5.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.7 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 2.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 2.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.0 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones