Motif ID: HOXC11

Z-value: 0.480


Transcription factors associated with HOXC11:

Gene SymbolEntrez IDGene Name
HOXC11 ENSG00000123388.4 HOXC11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXC11hg19_v2_chr12_+_54366894_54366922-0.433.8e-02Click!


Activity profile for motif HOXC11.

activity profile for motif HOXC11


Sorted Z-values histogram for motif HOXC11

Sorted Z-values for motif HOXC11



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC11

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_148521381 1.160 ENST00000504238.1
 ABLIM3
actin binding LIM protein family, member 3
chr9_-_124989804 0.804 ENST00000373755.2
ENST00000373754.2
 LHX6

LIM homeobox 6

chr14_-_57272366 0.764 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
 OTX2


orthodenticle homeobox 2


chr9_-_124976185 0.713 ENST00000464484.2
 LHX6
LIM homeobox 6
chr9_-_124976154 0.704 ENST00000482062.1
 LHX6
LIM homeobox 6
chr8_+_26435359 0.489 ENST00000311151.5
 DPYSL2
dihydropyrimidinase-like 2
chr2_+_228678550 0.482 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr1_-_204135450 0.453 ENST00000272190.8
ENST00000367195.2
 REN

renin

chr7_-_93519471 0.450 ENST00000451238.1
 TFPI2
tissue factor pathway inhibitor 2
chr20_+_58179582 0.449 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr4_+_169013666 0.444 ENST00000359299.3
 ANXA10
annexin A10
chr1_+_209878182 0.427 ENST00000367027.3
 HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr9_-_124990680 0.418 ENST00000541397.2
ENST00000560485.1
 LHX6

LIM homeobox 6

chr7_-_41742697 0.411 ENST00000242208.4
 INHBA
inhibin, beta A
chr9_+_75229616 0.392 ENST00000340019.3
 TMC1
transmembrane channel-like 1
chr3_-_37216055 0.388 ENST00000336686.4
 LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr1_+_209859510 0.382 ENST00000367028.2
ENST00000261465.1
 HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr15_+_67418047 0.365 ENST00000540846.2
 SMAD3
SMAD family member 3
chrX_-_107682702 0.363 ENST00000372216.4
 COL4A6
collagen, type IV, alpha 6
chr7_+_134464414 0.346 ENST00000361901.2
 CALD1
caldesmon 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.0 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.8 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.6 GO:0006825 copper ion transport(GO:0006825)
0.2 0.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.5 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 0.5 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.5 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 0.4 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.4 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.3 GO:0035878 nail development(GO:0035878)
0.1 0.2 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.3 0.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 0.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.5 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.3 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR