Motif ID: HOXC12_HOXD12

Z-value: 1.357

Transcription factors associated with HOXC12_HOXD12:

Gene SymbolEntrez IDGene Name
HOXC12 ENSG00000123407.3 HOXC12
HOXD12 ENSG00000170178.5 HOXD12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD12hg19_v2_chr2_+_176964458_176964540-0.564.2e-03Click!
HOXC12hg19_v2_chr12_+_54348618_54348693-0.087.2e-01Click!


Activity profile for motif HOXC12_HOXD12.

activity profile for motif HOXC12_HOXD12


Sorted Z-values histogram for motif HOXC12_HOXD12

Sorted Z-values for motif HOXC12_HOXD12



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC12_HOXD12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_2709527 15.340 ENST00000250784.8
 RPS4Y1
ribosomal protein S4, Y-linked 1
chrY_+_2709906 6.052 ENST00000430575.1
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr19_-_55677999 4.869 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
 DNAAF3


dynein, axonemal, assembly factor 3


chr7_+_6797288 3.570 ENST00000433859.2
ENST00000359718.3
 RSPH10B2

radial spoke head 10 homolog B2 (Chlamydomonas)

chr3_-_19975665 3.558 ENST00000295824.9
ENST00000389256.4
 EFHB

EF-hand domain family, member B

chr7_-_6006768 3.412 ENST00000441023.2
 RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr11_-_102668879 3.309 ENST00000315274.6
 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr19_-_55677920 3.225 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr17_+_11501748 2.587 ENST00000262442.4
ENST00000579828.1
 DNAH9

dynein, axonemal, heavy chain 9

chr3_+_63638339 2.387 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr9_-_124976185 2.269 ENST00000464484.2
 LHX6
LIM homeobox 6
chr8_+_101170563 2.269 ENST00000520508.1
ENST00000388798.2
 SPAG1

sperm associated antigen 1

chr9_-_124976154 2.212 ENST00000482062.1
 LHX6
LIM homeobox 6
chr1_-_47407097 2.150 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr12_-_71551652 2.086 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr1_+_171060018 2.083 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
 FMO3




flavin containing monooxygenase 3




chr7_+_152456904 1.863 ENST00000537264.1
 ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
chr3_-_172241250 1.840 ENST00000420541.2
ENST00000241261.2
 TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

chr4_-_16085340 1.744 ENST00000508167.1
 PROM1
prominin 1
chr8_-_33370607 1.738 ENST00000360742.5
ENST00000523305.1
 TTI2

TELO2 interacting protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 10.4 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.3 4.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.8 3.4 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 3.3 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.2 3.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 2.9 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 2.5 GO:0051764 actin crosslink formation(GO:0051764)
0.1 2.5 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.6 2.3 GO:0003095 pressure natriuresis(GO:0003095)
0.1 2.3 GO:0003341 cilium movement(GO:0003341)
0.7 2.1 GO:0042351 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
0.4 1.8 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.8 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 1.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 1.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.3 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 1.3 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.1 1.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.4 GO:0005844 polysome(GO:0005844)
0.2 3.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 3.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 2.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 2.7 GO:0031941 filamentous actin(GO:0031941)
0.0 2.6 GO:0016459 myosin complex(GO:0016459)
0.0 2.3 GO:0030286 dynein complex(GO:0030286)
0.2 1.8 GO:0097255 R2TP complex(GO:0097255)
0.1 1.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 1.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.2 GO:0032982 myosin filament(GO:0032982)
0.0 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.2 0.9 GO:1990423 RZZ complex(GO:1990423)
0.2 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.8 GO:0019843 rRNA binding(GO:0019843)
0.1 4.6 GO:0042805 actinin binding(GO:0042805)
0.5 3.2 GO:0032089 NACHT domain binding(GO:0032089)
0.3 2.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 2.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.6 2.3 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 2.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 2.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 2.1 GO:0005178 integrin binding(GO:0005178)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 1.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.8 GO:0016853 isomerase activity(GO:0016853)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.4 GO:0032052 bile acid binding(GO:0032052)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.8 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 5.5 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 4.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 3.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.8 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.8 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease