Motif ID: HOXC8

Z-value: 1.168


Transcription factors associated with HOXC8:

Gene SymbolEntrez IDGene Name
HOXC8 ENSG00000037965.4 HOXC8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXC8hg19_v2_chr12_+_54402790_544028320.358.9e-02Click!


Activity profile for motif HOXC8.

activity profile for motif HOXC8


Sorted Z-values histogram for motif HOXC8

Sorted Z-values for motif HOXC8



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXC8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_46655538 8.297 ENST00000303383.3
 SHCBP1
SHC SH2-domain binding protein 1
chr8_-_27695552 5.034 ENST00000522944.1
ENST00000301905.4
 PBK

PDZ binding kinase

chr1_-_153113927 4.698 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr1_+_120839412 4.569 ENST00000355228.4
 FAM72B
family with sequence similarity 72, member B
chr1_-_153066998 4.227 ENST00000368750.3
 SPRR2E
small proline-rich protein 2E
chr6_+_151646800 4.225 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_206138884 4.165 ENST00000341209.5
ENST00000607379.1
 FAM72A

family with sequence similarity 72, member A

chr1_+_45205478 4.123 ENST00000452259.1
ENST00000372224.4
 KIF2C

kinesin family member 2C

chr1_-_153085984 3.967 ENST00000468739.1
 SPRR2F
small proline-rich protein 2F
chr17_+_62223320 3.605 ENST00000580828.1
ENST00000582965.1
 SNORA76

small nucleolar RNA, H/ACA box 76

chr1_-_153029980 3.459 ENST00000392653.2
 SPRR2A
small proline-rich protein 2A
chr1_+_45205498 3.410 ENST00000372218.4
 KIF2C
kinesin family member 2C
chr12_-_10978957 3.371 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr4_-_57524061 3.306 ENST00000508121.1
 HOPX
HOP homeobox
chr19_-_43382142 3.289 ENST00000597058.1
 PSG1
pregnancy specific beta-1-glycoprotein 1
chr12_-_57634475 3.263 ENST00000393825.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr1_+_152975488 3.214 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr1_-_153013588 3.015 ENST00000360379.3
 SPRR2D
small proline-rich protein 2D
chr1_+_152956549 2.693 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr20_-_54967187 2.685 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A














Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 474 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.0 GO:0018149 peptide cross-linking(GO:0018149)
0.1 9.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 7.6 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.8 7.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 6.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 6.7 GO:0030449 regulation of complement activation(GO:0030449)
0.1 6.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.4 6.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 5.5 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.1 4.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 4.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.7 4.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.4 3.9 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.8 3.8 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.5 3.8 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.9 3.5 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.7 3.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.5 3.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 3.2 GO:0006968 cellular defense response(GO:0006968)
0.6 3.1 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.2 GO:0001533 cornified envelope(GO:0001533)
0.4 14.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 13.9 GO:0005925 focal adhesion(GO:0005925)
0.0 9.1 GO:0030027 lamellipodium(GO:0030027)
0.0 7.6 GO:0030496 midbody(GO:0030496)
0.1 4.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 4.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.6 4.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 4.1 GO:0005882 intermediate filament(GO:0005882)
1.3 3.9 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 3.6 GO:0005776 autophagosome(GO:0005776)
0.7 3.5 GO:0097149 centralspindlin complex(GO:0097149)
0.4 3.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 3.0 GO:0008091 spectrin(GO:0008091)
0.2 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.7 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 2.7 GO:0005610 laminin-5 complex(GO:0005610)
0.0 2.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 2.6 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 2.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 15.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 9.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 8.4 GO:0042169 SH2 domain binding(GO:0042169)
0.7 7.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.3 5.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 5.6 GO:0044325 ion channel binding(GO:0044325)
0.5 4.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 4.9 GO:0005549 odorant binding(GO:0005549)
0.2 4.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 4.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 4.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.8 3.2 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 3.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.6 3.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 3.0 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 5.8 PID_CDC42_PATHWAY CDC42 signaling events
0.0 4.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 3.3 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 3.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 2.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 10.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 6.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 5.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 4.1 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.2 3.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 3.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 3.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 3.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.0 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 2.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.4 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK