Motif ID: HOXD10
Z-value: 0.942
Transcription factors associated with HOXD10:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HOXD10 | ENSG00000128710.5 | HOXD10 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD10 | hg19_v2_chr2_+_176981307_176981307 | -0.15 | 5.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.3 | 0.8 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.3 | 0.8 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.2 | 0.7 | GO:2000196 | positive regulation of female gonad development(GO:2000196) |
| 0.2 | 0.6 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.2 | 0.6 | GO:0072579 | molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579) |
| 0.2 | 0.6 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 0.2 | 1.2 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.2 | 0.7 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.2 | 0.5 | GO:0018874 | benzoate metabolic process(GO:0018874) |
| 0.2 | 0.6 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.1 | 0.4 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.1 | 2.0 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 1.3 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.1 | 0.4 | GO:0010725 | regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854) |
| 0.1 | 0.4 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.1 | 0.8 | GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054) |
| 0.1 | 1.5 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.1 | 0.4 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 0.7 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.1 | 0.9 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.2 | GO:2001183 | negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.1 | 0.6 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.1 | 0.3 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 0.1 | 0.9 | GO:0032417 | positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.1 | 0.6 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.1 | 0.5 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.1 | 0.1 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.1 | 0.3 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.1 | 0.3 | GO:0071284 | response to platinum ion(GO:0070541) cellular response to lead ion(GO:0071284) |
| 0.1 | 0.9 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.1 | 0.5 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.1 | 0.3 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.1 | 0.5 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 0.3 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 0.1 | 0.2 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.1 | 0.1 | GO:0030805 | regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) |
| 0.1 | 1.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 1.0 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 0.3 | GO:0030070 | insulin processing(GO:0030070) |
| 0.1 | 0.6 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 3.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 0.2 | GO:0021526 | medial motor column neuron differentiation(GO:0021526) |
| 0.1 | 0.5 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 0.3 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
| 0.1 | 0.4 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.1 | 0.4 | GO:0003383 | apical constriction(GO:0003383) |
| 0.1 | 0.3 | GO:0010897 | negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252) |
| 0.1 | 0.2 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.1 | 0.3 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.0 | 0.3 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.0 | 0.2 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.0 | 1.0 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.0 | 0.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 4.0 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 0.2 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 0.2 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.0 | 0.2 | GO:0034599 | cellular response to oxidative stress(GO:0034599) |
| 0.0 | 0.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.4 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.0 | 0.2 | GO:0019249 | lactate biosynthetic process(GO:0019249) |
| 0.0 | 0.1 | GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.0 | 0.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.0 | 0.2 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.4 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.3 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.1 | GO:1900158 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.0 | 0.2 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.0 | 0.3 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.0 | 0.2 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.0 | 0.4 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.0 | 0.2 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.0 | 0.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.4 | GO:0045852 | pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
| 0.0 | 0.4 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.0 | 1.1 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.0 | 0.2 | GO:0009253 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) |
| 0.0 | 0.2 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.1 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.0 | 0.3 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.2 | GO:0009804 | coumarin metabolic process(GO:0009804) |
| 0.0 | 0.1 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 0.2 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.3 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 1.0 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.0 | 0.1 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.0 | 0.5 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.5 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.0 | 0.2 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.0 | 0.1 | GO:1903285 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 0.2 | GO:1901374 | acetate ester transport(GO:1901374) |
| 0.0 | 0.4 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 0.4 | GO:0086069 | bundle of His cell to Purkinje myocyte communication(GO:0086069) |
| 0.0 | 0.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.1 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.0 | 0.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.0 | 0.2 | GO:0034454 | microtubule anchoring at centrosome(GO:0034454) |
| 0.0 | 0.1 | GO:0007343 | egg activation(GO:0007343) |
| 0.0 | 1.0 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 0.2 | GO:0019530 | taurine metabolic process(GO:0019530) |
| 0.0 | 0.5 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.3 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 0.1 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.0 | 0.7 | GO:0042311 | vasodilation(GO:0042311) |
| 0.0 | 1.4 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 1.4 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.3 | GO:1904646 | cellular response to beta-amyloid(GO:1904646) |
| 0.0 | 0.0 | GO:0006711 | estrogen catabolic process(GO:0006711) |
| 0.0 | 0.2 | GO:0010886 | positive regulation of cholesterol storage(GO:0010886) |
| 0.0 | 0.1 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 0.2 | GO:0061303 | cornea development in camera-type eye(GO:0061303) |
| 0.0 | 0.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 2.1 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 0.3 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 0.0 | 0.3 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 0.1 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.0 | 0.0 | GO:0060620 | regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909) |
| 0.0 | 0.1 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.0 | 0.0 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.0 | 0.1 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.0 | 0.1 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.0 | 0.0 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.2 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.0 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.0 | 0.9 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.2 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.0 | 0.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.3 | 0.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 1.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.7 | GO:0002081 | outer acrosomal membrane(GO:0002081) |
| 0.1 | 0.4 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 7.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.4 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.7 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 0.7 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 1.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 0.3 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.1 | 0.4 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.1 | 0.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 0.6 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 1.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.4 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.3 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 0.6 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.5 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.2 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.1 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.0 | 0.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.4 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.9 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.8 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.2 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.2 | 0.6 | GO:0061599 | molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
| 0.2 | 0.9 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 0.6 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.1 | 0.7 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.6 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.1 | 0.3 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.1 | 0.3 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.1 | 2.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 1.1 | GO:0043855 | intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.1 | 0.2 | GO:0001181 | transcription factor activity, core RNA polymerase I binding(GO:0001181) |
| 0.1 | 0.7 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.1 | 0.7 | GO:0032190 | manganese ion transmembrane transporter activity(GO:0005384) acrosin binding(GO:0032190) |
| 0.1 | 0.3 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.1 | 0.2 | GO:0080130 | L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.1 | 1.0 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 0.6 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.1 | 0.4 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.1 | 0.2 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.1 | 0.3 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 0.3 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 0.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.2 | GO:0008513 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.0 | 0.1 | GO:0017130 | poly(C) RNA binding(GO:0017130) |
| 0.0 | 0.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 1.0 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 0.4 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.3 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.4 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.0 | 0.4 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.1 | GO:0031531 | thyrotropin-releasing hormone receptor binding(GO:0031531) |
| 0.0 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.6 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.1 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.5 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.2 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.4 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.2 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.2 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.5 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.0 | 0.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208) |
| 0.0 | 0.1 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.0 | 0.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.2 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 0.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 0.3 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.1 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.0 | 0.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.5 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 5.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.4 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.2 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.4 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 1.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.4 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 1.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.1 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 2.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.2 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.1 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.0 | 0.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.1 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.4 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.6 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.1 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.6 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.9 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.7 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.7 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.8 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.9 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.2 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.2 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.7 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.3 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.9 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.1 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.7 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
| 0.0 | 0.3 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.4 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.6 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.0 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 2.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.6 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.6 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.4 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.2 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.2 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_APOPTOSIS | Genes involved in Regulation of Apoptosis |
| 0.0 | 0.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
