Motif ID: HOXD10

Z-value: 0.942


Transcription factors associated with HOXD10:

Gene SymbolEntrez IDGene Name
HOXD10 ENSG00000128710.5 HOXD10

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD10hg19_v2_chr2_+_176981307_176981307-0.155.0e-01Click!


Activity profile for motif HOXD10.

activity profile for motif HOXD10


Sorted Z-values histogram for motif HOXD10

Sorted Z-values for motif HOXD10



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXD10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_68749745 2.039 ENST00000283916.6
 TMPRSS11D
transmembrane protease, serine 11D
chr5_+_96211643 1.991 ENST00000437043.3
ENST00000510373.1
 ERAP2

endoplasmic reticulum aminopeptidase 2

chr4_-_68749699 1.788 ENST00000545541.1
 TMPRSS11D
transmembrane protease, serine 11D
chr1_+_152975488 1.758 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr1_-_153113927 1.673 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr18_+_29027696 1.437 ENST00000257189.4
 DSG3
desmoglein 3
chr10_-_28623368 1.250 ENST00000441595.2
 MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr8_+_39770803 1.220 ENST00000518237.1
 IDO1
indoleamine 2,3-dioxygenase 1
chr2_-_214016314 1.162 ENST00000434687.1
ENST00000374319.4
 IKZF2

IKAROS family zinc finger 2 (Helios)

chr17_-_38938786 1.126 ENST00000301656.3
 KRT27
keratin 27
chr4_-_47983519 1.083 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
 CNGA1


cyclic nucleotide gated channel alpha 1


chr1_+_62439037 0.999 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr13_+_78109884 0.982 ENST00000377246.3
ENST00000349847.3
 SCEL

sciellin

chr7_+_132333553 0.974 ENST00000332558.4
 AC009365.3
AC009365.3
chr13_+_78109804 0.954 ENST00000535157.1
 SCEL
sciellin
chr9_-_21142144 0.931 ENST00000380229.2
 IFNW1
interferon, omega 1
chr15_+_41549105 0.892 ENST00000560965.1
 CHP1
calcineurin-like EF-hand protein 1
chr2_+_90458201 0.875 ENST00000603238.1
 CH17-132F21.1
Uncharacterized protein
chr2_-_161056762 0.868 ENST00000428609.2
ENST00000409967.2
 ITGB6

integrin, beta 6

chr4_+_71063641 0.813 ENST00000514097.1
 ODAM
odontogenic, ameloblast asssociated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 3.6 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.1 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 2.0 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 1.5 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 1.4 GO:0045576 mast cell activation(GO:0045576)
0.0 1.4 GO:0070268 cornification(GO:0070268)
0.1 1.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.3 1.2 GO:0036269 swimming behavior(GO:0036269)
0.2 1.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 1.1 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 1.0 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.0 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.9 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 0.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.9 GO:0000245 spliceosomal complex assembly(GO:0000245)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0001533 cornified envelope(GO:0001533)
0.5 1.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 1.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 1.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.1 0.7 GO:0002081 outer acrosomal membrane(GO:0002081)
0.1 0.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.7 GO:0089701 U2AF(GO:0089701)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.4 1.2 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 1.2 GO:0032947 protein complex scaffold(GO:0032947)
0.1 1.1 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0042923 neuropeptide binding(GO:0042923)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.7 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.7 GO:0032190 manganese ion transmembrane transporter activity(GO:0005384) acrosin binding(GO:0032190)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 0.6 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 0.6 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.6 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions