Motif ID: HOXD11_HOXA11

Z-value: 0.788

Transcription factors associated with HOXD11_HOXA11:

Gene SymbolEntrez IDGene Name
HOXA11 ENSG00000005073.5 HOXA11
HOXD11 ENSG00000128713.11 HOXD11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD11hg19_v2_chr2_+_176972000_1769720250.154.7e-01Click!
HOXA11hg19_v2_chr7_-_27224795_27224840,
hg19_v2_chr7_-_27224842_27224872		-0.038.7e-01Click!


Activity profile for motif HOXD11_HOXA11.

activity profile for motif HOXD11_HOXA11


Sorted Z-values histogram for motif HOXD11_HOXA11

Sorted Z-values for motif HOXD11_HOXA11



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXD11_HOXA11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 1.714 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr21_-_31869451 1.486 ENST00000334058.2
 KRTAP19-4
keratin associated protein 19-4
chr10_+_118187379 1.405 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr20_+_30102231 1.346 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
 HM13




histocompatibility (minor) 13




chr4_+_169013666 1.162 ENST00000359299.3
 ANXA10
annexin A10
chr1_+_62439037 1.136 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr4_-_68749699 1.120 ENST00000545541.1
 TMPRSS11D
transmembrane protease, serine 11D
chr11_+_76745385 1.099 ENST00000533140.1
ENST00000354301.5
ENST00000528622.1
 B3GNT6


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)


chr6_+_12290586 1.089 ENST00000379375.5
 EDN1
endothelin 1
chr2_+_158114051 1.066 ENST00000259056.4
 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr5_-_39270725 1.050 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
 FYB


FYN binding protein


chr4_-_68749745 0.926 ENST00000283916.6
 TMPRSS11D
transmembrane protease, serine 11D
chr9_-_21305312 0.879 ENST00000259555.4
 IFNA5
interferon, alpha 5
chr5_+_7654057 0.873 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr7_-_41742697 0.867 ENST00000242208.4
 INHBA
inhibin, beta A
chr7_+_134464376 0.811 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chrX_-_73072534 0.808 ENST00000429829.1
 XIST
X inactive specific transcript (non-protein coding)
chr21_-_31859755 0.802 ENST00000334055.3
 KRTAP19-2
keratin associated protein 19-2
chr12_-_25055177 0.787 ENST00000538118.1
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr4_+_86525299 0.783 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0031424 keratinization(GO:0031424)
0.6 1.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 1.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.4 1.1 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 1.1 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 1.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 0.9 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.9 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.9 GO:0046847 filopodium assembly(GO:0046847)
0.1 0.8 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.7 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.7 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.6 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.6 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0005882 intermediate filament(GO:0005882)
0.1 1.9 GO:0030478 actin cap(GO:0030478)
0.1 1.8 GO:0005577 fibrinogen complex(GO:0005577)
0.3 1.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.3 1.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 0.9 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.7 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.6 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.7 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.4 1.1 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.2 1.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 1.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 0.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.7 GO:0005503 all-trans retinal binding(GO:0005503)
0.1 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.7 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling