Motif ID: HOXD4

Z-value: 0.377


Transcription factors associated with HOXD4:

Gene SymbolEntrez IDGene Name
HOXD4 ENSG00000170166.5 HOXD4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD4hg19_v2_chr2_+_177015950_177015950-0.377.2e-02Click!


Activity profile for motif HOXD4.

activity profile for motif HOXD4


Sorted Z-values histogram for motif HOXD4

Sorted Z-values for motif HOXD4



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXD4

PNG image of the network

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Top targets:


Showing 1 to 20 of 179 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_63638339 1.098 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr5_-_13944652 0.941 ENST00000265104.4
 DNAH5
dynein, axonemal, heavy chain 5
chr17_+_9479944 0.806 ENST00000396219.3
ENST00000352665.5
 WDR16

WD repeat domain 16

chr4_-_70505358 0.677 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
 UGT2A2


UDP glucuronosyltransferase 2 family, polypeptide A2


chr5_-_137475071 0.667 ENST00000265191.2
 NME5
NME/NM23 family member 5
chr12_+_9980113 0.518 ENST00000537723.1
 KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr13_-_61989655 0.512 ENST00000409204.4
 PCDH20
protocadherin 20
chr3_+_97483572 0.476 ENST00000335979.2
ENST00000394206.1
 ARL6

ADP-ribosylation factor-like 6

chr1_-_60539422 0.435 ENST00000371201.3
 C1orf87
chromosome 1 open reading frame 87
chr2_-_159237472 0.356 ENST00000409187.1
 CCDC148
coiled-coil domain containing 148
chr7_-_25268104 0.351 ENST00000222674.2
 NPVF
neuropeptide VF precursor
chrX_+_36246735 0.348 ENST00000378653.3
 CXorf30
chromosome X open reading frame 30
chr16_-_3350614 0.344 ENST00000268674.2
 TIGD7
tigger transposable element derived 7
chr10_+_95848824 0.319 ENST00000371385.3
ENST00000371375.1
 PLCE1

phospholipase C, epsilon 1

chr7_-_137028498 0.319 ENST00000393083.2
 PTN
pleiotrophin
chr8_-_72274467 0.305 ENST00000340726.3
 EYA1
eyes absent homolog 1 (Drosophila)
chr13_+_24144509 0.303 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_87804815 0.300 ENST00000369582.2
 CGA
glycoprotein hormones, alpha polypeptide
chr4_+_146539415 0.294 ENST00000281317.5
 MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr5_+_69321074 0.293 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
 SERF1B



small EDRK-rich factor 1B (centromeric)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0036158 lateral ventricle development(GO:0021670) outer dynein arm assembly(GO:0036158)
0.1 0.7 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 0.6 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.5 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.4 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.3 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.3 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.1 GO:0051180 vitamin transport(GO:0051180)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.5 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.5 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis