Motif ID: HSF1

Z-value: 0.661


Transcription factors associated with HSF1:

Gene SymbolEntrez IDGene Name
HSF1 ENSG00000185122.6 HSF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_145515299-0.529.8e-03Click!


Activity profile for motif HSF1.

activity profile for motif HSF1


Sorted Z-values histogram for motif HSF1

Sorted Z-values for motif HSF1



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_31870927 3.647 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr6_-_33041378 3.521 ENST00000428995.1
 HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr19_-_55672037 3.070 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr20_+_18794370 2.456 ENST00000377428.2
 SCP2D1
SCP2 sterol-binding domain containing 1
chr6_-_32557610 2.222 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32498046 2.093 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr9_+_127615733 2.062 ENST00000373574.1
 WDR38
WD repeat domain 38
chr7_-_99573677 1.985 ENST00000292401.4
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr2_+_132286754 1.937 ENST00000434330.1
 CCDC74A
coiled-coil domain containing 74A
chr7_-_99573640 1.863 ENST00000411734.1
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr5_+_156696362 1.805 ENST00000377576.3
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_26624775 1.593 ENST00000288710.2
 DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr18_-_71815051 1.542 ENST00000582526.1
ENST00000419743.2
 FBXO15

F-box protein 15

chr18_-_71814999 1.528 ENST00000269500.5
 FBXO15
F-box protein 15
chr2_+_85981008 1.481 ENST00000306279.3
 ATOH8
atonal homolog 8 (Drosophila)
chr2_-_238499303 1.409 ENST00000409576.1
 RAB17
RAB17, member RAS oncogene family
chr3_+_42947600 1.372 ENST00000328199.6
ENST00000541208.1
 ZNF662

zinc finger protein 662

chr9_-_138391692 1.351 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr7_-_5821225 1.329 ENST00000416985.1
 RNF216
ring finger protein 216
chr7_-_138347897 1.290 ENST00000288513.5
 SVOPL
SVOP-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0031295 T cell costimulation(GO:0031295)
0.1 4.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 4.2 GO:0044458 motile cilium assembly(GO:0044458)
0.5 3.6 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.5 2.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4 2.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 2.2 GO:0032608 interferon-beta production(GO:0032608)
0.3 1.9 GO:0021523 somatic motor neuron differentiation(GO:0021523) protein localization to ciliary transition zone(GO:1904491)
0.2 1.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)
0.5 1.6 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 1.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.5 1.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 1.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.4 1.2 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.4 1.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.2 1.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 1.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 1.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.9 GO:0036038 MKS complex(GO:0036038)
0.0 1.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.5 1.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 1.4 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 1.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.2 GO:0042629 mast cell granule(GO:0042629)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.6 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.6 GO:0097542 ciliary tip(GO:0097542)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 4.8 GO:0042605 peptide antigen binding(GO:0042605)
0.2 3.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 1.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 1.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.3 GO:0008430 selenium binding(GO:0008430)
0.0 1.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.2 GO:0019239 deaminase activity(GO:0019239)
0.3 1.1 GO:0008513 secondary active organic cation transmembrane transporter activity(GO:0008513)
0.1 1.1 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 1.0 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0008395 steroid hydroxylase activity(GO:0008395)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.6 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.2 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.7 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport