Motif ID: HSF2

Z-value: 0.505


Transcription factors associated with HSF2:

Gene SymbolEntrez IDGene Name
HSF2 ENSG00000025156.8 HSF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF2hg19_v2_chr6_+_122720681_122720713-0.281.8e-01Click!


Activity profile for motif HSF2.

activity profile for motif HSF2


Sorted Z-values histogram for motif HSF2

Sorted Z-values for motif HSF2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_151646800 1.520 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chrX_+_135279179 1.170 ENST00000370676.3
 FHL1
four and a half LIM domains 1
chrX_+_135230712 1.136 ENST00000535737.1
 FHL1
four and a half LIM domains 1
chrX_+_135278908 1.038 ENST00000539015.1
ENST00000370683.1
 FHL1

four and a half LIM domains 1

chr13_-_20805109 0.990 ENST00000241124.6
 GJB6
gap junction protein, beta 6, 30kDa
chr16_+_55600580 0.968 ENST00000457326.2
 CAPNS2
calpain, small subunit 2
chr15_-_81616446 0.946 ENST00000302824.6
 STARD5
StAR-related lipid transfer (START) domain containing 5
chr12_-_10007448 0.929 ENST00000538152.1
 CLEC2B
C-type lectin domain family 2, member B
chr16_-_30125177 0.875 ENST00000406256.3
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr15_-_70388943 0.741 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
 TLE3






transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)






chr15_-_70388599 0.735 ENST00000560996.1
ENST00000558201.1
 TLE3

transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

chr6_-_53213587 0.721 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
 ELOVL5


ELOVL fatty acid elongase 5


chr7_+_130126012 0.657 ENST00000341441.5
 MEST
mesoderm specific transcript
chr7_+_130126165 0.653 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
 MEST


mesoderm specific transcript


chr10_+_135340859 0.587 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
 CYP2E1


cytochrome P450, family 2, subfamily E, polypeptide 1


chr19_-_14629224 0.555 ENST00000254322.2
 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr16_+_71392616 0.552 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
 CALB2


calbindin 2


chr9_+_34989638 0.550 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
 DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr10_-_90611566 0.535 ENST00000371930.4
 ANKRD22
ankyrin repeat domain 22
chr1_-_6453426 0.518 ENST00000545482.1
 ACOT7
acyl-CoA thioesterase 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 1.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 1.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 1.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 1.1 GO:0051602 response to electrical stimulus(GO:0051602)
0.3 1.0 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.9 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 0.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.8 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.7 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.6 GO:0010193 response to ozone(GO:0010193)
0.0 0.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.5 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.5 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.0 0.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.4 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.4 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0005922 connexon complex(GO:0005922)
0.3 0.9 GO:0097447 dendritic tree(GO:0097447)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.4 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.4 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0044325 ion channel binding(GO:0044325)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.0 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.9 GO:0032052 bile acid binding(GO:0032052)
0.1 0.8 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.7 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.6 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.9 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.9 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions