Motif ID: HSF4

Z-value: 0.559


Transcription factors associated with HSF4:

Gene SymbolEntrez IDGene Name
HSF4 ENSG00000102878.11 HSF4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67198683_671987150.262.2e-01Click!


Activity profile for motif HSF4.

activity profile for motif HSF4


Sorted Z-values histogram for motif HSF4

Sorted Z-values for motif HSF4



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_74137374 2.370 ENST00000322957.6
 FOXJ1
forkhead box J1
chr18_-_71815051 2.007 ENST00000582526.1
ENST00000419743.2
 FBXO15

F-box protein 15

chr18_-_71814999 2.000 ENST00000269500.5
 FBXO15
F-box protein 15
chr19_-_55672037 1.852 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr1_-_60539405 1.472 ENST00000450089.2
 C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 1.460 ENST00000371201.3
 C1orf87
chromosome 1 open reading frame 87
chr2_-_238499303 1.125 ENST00000409576.1
 RAB17
RAB17, member RAS oncogene family
chr1_-_173638976 1.099 ENST00000333279.2
 ANKRD45
ankyrin repeat domain 45
chr5_+_140602904 0.900 ENST00000515856.2
ENST00000239449.4
 PCDHB14

protocadherin beta 14

chr1_-_26633067 0.882 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
 UBXN11








UBX domain protein 11








chr13_-_31736027 0.858 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
 HSPH1


heat shock 105kDa/110kDa protein 1


chr5_-_13944652 0.817 ENST00000265104.4
 DNAH5
dynein, axonemal, heavy chain 5
chr11_-_122932730 0.815 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
 HSPA8




heat shock 70kDa protein 8




chr9_+_33025209 0.814 ENST00000330899.4
ENST00000544625.1
 DNAJA1

DnaJ (Hsp40) homolog, subfamily A, member 1

chr19_-_6720686 0.797 ENST00000245907.6
 C3
complement component 3
chr11_-_89956461 0.780 ENST00000320585.6
 CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr13_-_31736132 0.777 ENST00000429785.2
 HSPH1
heat shock 105kDa/110kDa protein 1
chr11_-_122933043 0.761 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
 HSPA8


heat shock 70kDa protein 8


chr11_-_89956227 0.761 ENST00000457199.2
ENST00000530765.1
 CHORDC1

cysteine and histidine-rich domain (CHORD) containing 1

chr7_-_56119156 0.727 ENST00000421312.1
ENST00000416592.1
 PSPH

phosphoserine phosphatase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.8 2.4 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.3 2.2 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.2 2.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 1.7 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.3 1.6 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.5 1.5 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 1.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 1.1 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.0 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 0.8 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.8 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.2 0.7 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 0.6 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.6 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.5 GO:0043335 protein unfolding(GO:0043335)
0.0 0.5 GO:2000781 positive regulation of double-strand break repair(GO:2000781)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.6 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 1.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.8 GO:0036157 outer dynein arm(GO:0036157)
0.2 0.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.3 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 2.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 2.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 1.1 GO:0019239 deaminase activity(GO:0019239)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.5 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 0.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.5 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.8 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome