Motif ID: HSFY2

Z-value: 0.888


Transcription factors associated with HSFY2:

Gene SymbolEntrez IDGene Name
HSFY2 ENSG00000169953.11 HSFY2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSFY2hg19_v2_chrY_-_20935572_209356210.564.4e-03Click!


Activity profile for motif HSFY2.

activity profile for motif HSFY2


Sorted Z-values histogram for motif HSFY2

Sorted Z-values for motif HSFY2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSFY2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_163148161 1.955 ENST00000337019.3
ENST00000366889.2
 PACRG

PARK2 co-regulated

chr4_+_81256871 1.892 ENST00000358105.3
ENST00000508675.1
 C4orf22

chromosome 4 open reading frame 22

chr19_+_5720666 1.578 ENST00000381624.3
ENST00000381614.2
 CATSPERD

catsper channel auxiliary subunit delta

chr1_+_111888890 1.557 ENST00000369738.4
 PIFO
primary cilia formation
chr7_+_105603683 1.453 ENST00000317716.9
 CDHR3
cadherin-related family member 3
chr10_+_70587279 1.354 ENST00000298596.6
ENST00000399169.4
ENST00000399165.4
ENST00000399162.2
 STOX1



storkhead box 1



chr6_+_163148973 1.231 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr1_+_111889212 1.213 ENST00000369737.4
 PIFO
primary cilia formation
chr7_+_105603657 1.159 ENST00000542731.1
ENST00000343407.5
 CDHR3

cadherin-related family member 3

chr6_-_10838736 1.114 ENST00000536370.1
ENST00000474039.1
 MAK

male germ cell-associated kinase

chr4_+_52917451 1.092 ENST00000295213.4
ENST00000419395.2
 SPATA18

spermatogenesis associated 18

chr19_-_55677920 1.022 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr11_-_71318487 1.012 ENST00000343767.3
 AP000867.1
AP000867.1
chr2_-_209028300 0.960 ENST00000304502.4
 CRYGA
crystallin, gamma A
chr1_+_1109272 0.955 ENST00000379290.1
ENST00000379289.1
 TTLL10

tubulin tyrosine ligase-like family, member 10

chr7_-_6010263 0.947 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr7_+_89874524 0.932 ENST00000497910.1
 C7orf63
chromosome 7 open reading frame 63
chr5_+_68860949 0.924 ENST00000507595.1
 GTF2H2C
general transcription factor IIH, polypeptide 2C
chr6_-_10838710 0.910 ENST00000313243.2
 MAK
male germ cell-associated kinase
chr2_-_28113965 0.908 ENST00000302188.3
 RBKS
ribokinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0007286 spermatid development(GO:0007286)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.0 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.5 1.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 1.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 1.5 GO:0048240 sperm capacitation(GO:0048240)
0.2 1.4 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.0 1.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.2 1.0 GO:0018094 protein polyglycylation(GO:0018094)
0.1 1.0 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 1.0 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.3 0.9 GO:0032203 telomere formation via telomerase(GO:0032203)
0.2 0.9 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.0 0.8 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.7 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.7 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.7 GO:0035721 intraciliary retrograde transport(GO:0035721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0097542 ciliary tip(GO:0097542)
0.1 3.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.7 GO:0036064 ciliary basal body(GO:0036064)
0.2 1.6 GO:0036128 CatSper complex(GO:0036128)
0.0 1.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.7 GO:1990716 axonemal central apparatus(GO:1990716)
0.2 0.7 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.1 0.6 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.9 GO:0001618 virus receptor activity(GO:0001618)
0.4 1.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 1.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.8 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.8 GO:0031433 telethonin binding(GO:0031433)
0.0 0.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 0.6 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.5 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.4 GO:0022865 transmembrane electron transfer carrier(GO:0022865)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol