Motif ID: IKZF1

Z-value: 2.372


Transcription factors associated with IKZF1:

Gene SymbolEntrez IDGene Name
IKZF1 ENSG00000185811.12 IKZF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF1hg19_v2_chr7_+_50348268_503483660.631.0e-03Click!


Activity profile for motif IKZF1.

activity profile for motif IKZF1


Sorted Z-values histogram for motif IKZF1

Sorted Z-values for motif IKZF1



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 18.242 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr19_-_51466681 13.582 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr19_-_51456198 13.054 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 11.844 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr22_+_31488433 11.597 ENST00000455608.1
 SMTN
smoothelin
chr19_-_51456321 11.496 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr19_-_51471381 11.013 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr12_-_57630873 10.424 ENST00000556732.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_-_51471362 9.720 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr15_-_90039805 8.610 ENST00000544600.1
ENST00000268122.4
 RHCG

Rh family, C glycoprotein

chr1_-_17307173 7.335 ENST00000438542.1
ENST00000375535.3
 MFAP2

microfibrillar-associated protein 2

chr1_+_150480551 6.993 ENST00000369049.4
ENST00000369047.4
 ECM1

extracellular matrix protein 1

chr1_+_150480576 6.952 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr19_-_19051103 6.625 ENST00000542541.2
ENST00000433218.2
 HOMER3

homer homolog 3 (Drosophila)

chr2_+_95691445 6.523 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL


mal, T-cell differentiation protein


chr9_-_139891165 6.523 ENST00000494426.1
 CLIC3
chloride intracellular channel 3
chr12_+_8975061 6.134 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr19_-_43269809 6.042 ENST00000406636.3
ENST00000404209.4
ENST00000306511.4
 PSG8


pregnancy specific beta-1-glycoprotein 8


chr11_+_61583721 5.916 ENST00000257261.6
 FADS2
fatty acid desaturase 2
chr8_-_23261589 5.853 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,601 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 72.1 GO:0070268 cornification(GO:0070268)
10.1 60.4 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.9 42.1 GO:0016540 protein autoprocessing(GO:0016540)
3.4 27.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.9 24.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.8 23.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 20.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.8 18.8 GO:0032060 bleb assembly(GO:0032060)
0.8 18.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.8 16.1 GO:0000022 mitotic spindle elongation(GO:0000022)
0.7 14.6 GO:0030502 negative regulation of bone mineralization(GO:0030502)
3.5 14.2 GO:0006218 uridine catabolic process(GO:0006218)
0.1 14.0 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.4 13.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 13.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.3 13.5 GO:0051310 metaphase plate congression(GO:0051310)
1.5 13.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.6 12.9 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
1.0 11.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.0 11.5 GO:0009629 response to gravity(GO:0009629)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 487 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 70.6 GO:0005615 extracellular space(GO:0005615)
8.6 60.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 57.6 GO:0030027 lamellipodium(GO:0030027)
0.8 52.8 GO:0001533 cornified envelope(GO:0001533)
0.1 45.0 GO:0005925 focal adhesion(GO:0005925)
1.9 35.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.0 24.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 23.8 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 20.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 18.8 GO:0035371 microtubule plus-end(GO:0035371)
0.2 18.4 GO:0005901 caveola(GO:0005901)
0.2 17.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 16.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 16.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.2 15.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 13.7 GO:0031674 I band(GO:0031674)
0.4 13.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 12.3 GO:0045095 keratin filament(GO:0045095)
0.1 12.2 GO:0032587 ruffle membrane(GO:0032587)
0.4 12.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 871 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 155.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 59.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 48.2 GO:0045296 cadherin binding(GO:0045296)
0.2 37.5 GO:0051015 actin filament binding(GO:0051015)
0.1 37.0 GO:0005096 GTPase activator activity(GO:0005096)
0.2 30.2 GO:0030674 protein binding, bridging(GO:0030674)
0.2 26.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.4 21.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 20.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 19.9 GO:0005504 fatty acid binding(GO:0005504)
0.2 17.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 16.1 GO:0005198 structural molecule activity(GO:0005198)
1.0 14.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 14.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.9 14.4 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.8 14.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.0 14.1 GO:0031014 troponin T binding(GO:0031014)
1.2 12.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 12.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.5 11.8 GO:0030506 ankyrin binding(GO:0030506)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 61.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.2 54.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 43.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 43.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 30.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 19.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
1.3 17.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 17.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.4 17.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 16.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 16.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.7 15.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 14.5 PID_LKB1_PATHWAY LKB1 signaling events
0.3 13.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 12.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 12.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 11.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 11.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 11.0 PID_PLK1_PATHWAY PLK1 signaling events
0.3 10.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 53.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 29.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 23.8 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
1.1 22.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 21.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.5 21.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.4 20.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.5 19.2 REACTOME_KINESINS Genes involved in Kinesins
0.4 19.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
1.1 18.8 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.5 17.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 17.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 16.8 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.4 15.9 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.9 15.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 15.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 14.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.7 13.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 13.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 13.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism