Motif ID: IKZF2

Z-value: 0.715


Transcription factors associated with IKZF2:

Gene SymbolEntrez IDGene Name
IKZF2 ENSG00000030419.12 IKZF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v2_chr2_-_214016314_214016343-0.067.6e-01Click!


Activity profile for motif IKZF2.

activity profile for motif IKZF2


Sorted Z-values histogram for motif IKZF2

Sorted Z-values for motif IKZF2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_92219919 0.882 ENST00000252506.6
ENST00000375769.1
GADD45G

growth arrest and DNA-damage-inducible, gamma

chr20_+_58179582 0.865 ENST00000371015.1
ENST00000395639.4
PHACTR3

phosphatase and actin regulator 3

chr12_+_26348582 0.554 ENST00000535504.1
SSPN
sarcospan
chr6_+_32605195 0.537 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_216257849 0.495 ENST00000456923.1
FN1
fibronectin 1
chr14_+_32546145 0.462 ENST00000556611.1
ENST00000539826.2
ARHGAP5

Rho GTPase activating protein 5

chr6_+_32605134 0.453 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr1_-_157014865 0.427 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr4_+_86525299 0.403 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr17_+_26369865 0.393 ENST00000582037.1
NLK
nemo-like kinase
chr15_-_90358048 0.382 ENST00000300060.6
ENST00000560137.1
ANPEP

alanyl (membrane) aminopeptidase

chr22_+_40297105 0.372 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr12_-_52867569 0.370 ENST00000252250.6
KRT6C
keratin 6C
chr12_-_81763127 0.369 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_-_161337662 0.362 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr12_-_81763184 0.360 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2


protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


chr9_-_3469181 0.345 ENST00000366116.2
AL365202.1
Uncharacterized protein
chrX_-_15683147 0.339 ENST00000380342.3
TMEM27
transmembrane protein 27
chr22_+_40297079 0.329 ENST00000344138.4
ENST00000543252.1
GRAP2

GRB2-related adaptor protein 2

chr1_+_111889212 0.328 ENST00000369737.4
PIFO
primary cilia formation
chr22_-_36220420 0.327 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_+_73164149 0.317 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
JPX




JPX transcript, XIST activator (non-protein coding)




chr6_-_55739542 0.312 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr1_+_111888890 0.311 ENST00000369738.4
PIFO
primary cilia formation
chr5_+_43602750 0.297 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT


nicotinamide nucleotide transhydrogenase


chr8_+_104831554 0.294 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr21_+_17909594 0.291 ENST00000441820.1
ENST00000602280.1
LINC00478

long intergenic non-protein coding RNA 478

chr16_-_33647696 0.286 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9

Uncharacterized protein

chr5_+_17444119 0.279 ENST00000503267.1
ENST00000504998.1
RP11-321E2.4

RP11-321E2.4

chr6_+_27107053 0.271 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chr17_+_7387919 0.266 ENST00000572844.1
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr6_+_123110465 0.264 ENST00000539041.1
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr5_-_147211190 0.262 ENST00000510027.2
SPINK1
serine peptidase inhibitor, Kazal type 1
chr17_-_7120498 0.260 ENST00000485100.1
DLG4
discs, large homolog 4 (Drosophila)
chr4_-_157892167 0.247 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr19_-_51141196 0.246 ENST00000338916.4
SYT3
synaptotagmin III
chr14_-_36988882 0.246 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr10_-_11574274 0.244 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr8_-_18541603 0.241 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr4_-_146859787 0.240 ENST00000508784.1
ZNF827
zinc finger protein 827
chr1_-_242612779 0.240 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr4_-_168155700 0.235 ENST00000357545.4
ENST00000512648.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr15_+_69373184 0.234 ENST00000558147.1
ENST00000440444.1
LINC00277

long intergenic non-protein coding RNA 277

chr14_+_32546274 0.230 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr21_+_26934165 0.230 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr17_+_7387677 0.227 ENST00000322644.6
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr6_+_123110302 0.223 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr4_-_120243545 0.223 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr15_-_20193370 0.223 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr1_+_228870824 0.221 ENST00000366691.3
RHOU
ras homolog family member U
chr4_-_146859623 0.221 ENST00000379448.4
ENST00000513320.1
ZNF827

zinc finger protein 827

chr19_+_44220247 0.219 ENST00000596627.1
IRGC
immunity-related GTPase family, cinema
chr5_+_1225470 0.219 ENST00000324642.3
ENST00000296821.4
SLC6A18

solute carrier family 6 (neutral amino acid transporter), member 18

chr10_-_79398250 0.215 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr19_-_43422019 0.208 ENST00000402603.4
ENST00000594375.1
PSG6

pregnancy specific beta-1-glycoprotein 6

chr12_+_121570631 0.206 ENST00000546057.1
ENST00000377162.2
ENST00000328963.5
ENST00000535250.1
ENST00000541446.1
P2RX7




purinergic receptor P2X, ligand-gated ion channel, 7




chr4_-_83765613 0.203 ENST00000503937.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr4_-_157892498 0.202 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr12_-_91573316 0.198 ENST00000393155.1
DCN
decorin
chr10_+_81892477 0.197 ENST00000372263.3
PLAC9
placenta-specific 9
chr5_-_42811986 0.197 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1


selenoprotein P, plasma, 1


chr9_+_5510558 0.196 ENST00000397747.3
PDCD1LG2
programmed cell death 1 ligand 2
chr6_-_26056695 0.196 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr5_-_42812143 0.195 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr3_-_169487617 0.194 ENST00000330368.2
ACTRT3
actin-related protein T3
chr2_+_101437487 0.193 ENST00000427413.1
ENST00000542504.1
NPAS2

neuronal PAS domain protein 2

chr8_-_133637624 0.192 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr12_+_60058458 0.187 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_18496957 0.187 ENST00000252809.3
GDF15
growth differentiation factor 15
chr2_-_228244013 0.187 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chrX_+_73164167 0.186 ENST00000414209.1
ENST00000602895.1
ENST00000453317.1
ENST00000602546.1
ENST00000602985.1
ENST00000415215.1
JPX





JPX transcript, XIST activator (non-protein coding)





chr2_+_189839046 0.186 ENST00000304636.3
ENST00000317840.5
COL3A1

collagen, type III, alpha 1

chrX_-_63425561 0.186 ENST00000374869.3
ENST00000330258.3
AMER1

APC membrane recruitment protein 1

chr7_-_16505440 0.186 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr20_+_52105495 0.185 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr19_-_43269809 0.183 ENST00000406636.3
ENST00000404209.4
ENST00000306511.4
PSG8


pregnancy specific beta-1-glycoprotein 8


chr8_+_30244580 0.183 ENST00000523115.1
ENST00000519647.1
RBPMS

RNA binding protein with multiple splicing

chr10_+_77056134 0.182 ENST00000528121.1
ENST00000416398.1
ZNF503-AS1

ZNF503 antisense RNA 1

chr3_+_178866199 0.182 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr12_-_91573132 0.181 ENST00000550563.1
ENST00000546370.1
DCN

decorin

chr14_+_45431379 0.180 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
FAM179B


family with sequence similarity 179, member B


chr2_-_24583168 0.180 ENST00000361999.3
ITSN2
intersectin 2
chr4_-_114900831 0.180 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr1_+_21880560 0.179 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr7_-_92848858 0.178 ENST00000440868.1
HEPACAM2
HEPACAM family member 2
chr7_-_92848878 0.178 ENST00000341723.4
HEPACAM2
HEPACAM family member 2
chr17_+_77018896 0.178 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_+_105404899 0.177 ENST00000345080.4
LIN28B
lin-28 homolog B (C. elegans)
chr3_-_112329110 0.177 ENST00000479368.1
CCDC80
coiled-coil domain containing 80
chr17_-_7120525 0.173 ENST00000447163.1
ENST00000399506.2
ENST00000302955.6
DLG4


discs, large homolog 4 (Drosophila)


chr9_+_125376948 0.171 ENST00000297913.2
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr17_-_26127525 0.171 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chr3_+_57882024 0.169 ENST00000494088.1
SLMAP
sarcolemma associated protein
chr17_+_77019030 0.168 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr12_-_71551652 0.168 ENST00000546561.1
TSPAN8
tetraspanin 8
chr14_-_45431091 0.168 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28


kelch-like family member 28


chr1_+_209941942 0.167 ENST00000487271.1
ENST00000477431.1
TRAF3IP3

TRAF3 interacting protein 3

chr8_-_15095832 0.167 ENST00000382080.1
SGCZ
sarcoglycan, zeta
chr5_+_173316341 0.167 ENST00000520867.1
ENST00000334035.5
CPEB4

cytoplasmic polyadenylation element binding protein 4

chr3_+_148508845 0.167 ENST00000491148.1
CPB1
carboxypeptidase B1 (tissue)
chr4_+_39184024 0.165 ENST00000399820.3
ENST00000509560.1
ENST00000512112.1
ENST00000288634.7
ENST00000506503.1
WDR19




WD repeat domain 19




chr2_-_127963343 0.164 ENST00000335247.7
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr4_-_157892055 0.163 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr4_-_89978299 0.163 ENST00000511976.1
ENST00000509094.1
ENST00000264344.5
ENST00000515600.1
FAM13A



family with sequence similarity 13, member A



chr8_-_82024290 0.163 ENST00000220597.4
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr11_-_102595681 0.162 ENST00000236826.3
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr12_-_110511424 0.162 ENST00000548191.1
C12orf76
chromosome 12 open reading frame 76
chr3_-_114035026 0.160 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr7_+_107224364 0.160 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr6_+_149539767 0.159 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2

RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2

RP1-111D6.3
chr2_+_233897382 0.159 ENST00000233840.3
NEU2
sialidase 2 (cytosolic sialidase)
chr10_-_100995603 0.159 ENST00000370552.3
ENST00000370549.1
HPSE2

heparanase 2

chr19_-_12777509 0.157 ENST00000221363.4
ENST00000598876.1
ENST00000456935.2
ENST00000486847.2
MAN2B1



mannosidase, alpha, class 2B, member 1



chr3_+_57881966 0.157 ENST00000495364.1
SLMAP
sarcolemma associated protein
chr6_+_167536230 0.156 ENST00000341935.5
ENST00000349984.4
CCR6

chemokine (C-C motif) receptor 6

chr5_-_135701164 0.153 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr19_-_54106751 0.150 ENST00000600193.1
CTB-167G5.5
Uncharacterized protein
chrX_+_80457442 0.149 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_+_102686820 0.148 ENST00000409929.1
ENST00000424272.1
IL1R1

interleukin 1 receptor, type I

chr18_-_5895954 0.148 ENST00000581347.2
TMEM200C
transmembrane protein 200C
chr7_-_74221288 0.148 ENST00000451013.2
GTF2IRD2
GTF2I repeat domain containing 2
chr19_-_47290535 0.147 ENST00000412532.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr6_+_43149903 0.147 ENST00000252050.4
ENST00000354495.3
ENST00000372647.2
CUL9


cullin 9


chr9_+_5510492 0.147 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chrX_-_43741594 0.146 ENST00000536181.1
ENST00000378069.4
MAOB

monoamine oxidase B

chr1_-_57045228 0.142 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_49449107 0.141 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr19_+_30863271 0.141 ENST00000355537.3
ZNF536
zinc finger protein 536
chr18_-_24237339 0.140 ENST00000580191.1
KCTD1
potassium channel tetramerization domain containing 1
chr10_-_76868931 0.140 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13




dual specificity phosphatase 13




chr1_+_104198377 0.139 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chrX_-_30993201 0.139 ENST00000288422.2
ENST00000378932.2
TAB3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

chr12_+_26348246 0.138 ENST00000422622.2
SSPN
sarcospan
chr3_-_18480260 0.138 ENST00000454909.2
SATB1
SATB homeobox 1
chr19_+_48773337 0.137 ENST00000595607.1
ZNF114
zinc finger protein 114
chr7_+_1126461 0.136 ENST00000297469.3
GPER1
G protein-coupled estrogen receptor 1
chr5_+_140557371 0.134 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr8_-_6420759 0.134 ENST00000523120.1
ANGPT2
angiopoietin 2
chr3_-_18466026 0.133 ENST00000417717.2
SATB1
SATB homeobox 1
chr13_-_99959641 0.132 ENST00000376414.4
GPR183
G protein-coupled receptor 183
chr8_+_26240414 0.132 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr18_-_55253989 0.131 ENST00000262093.5
FECH
ferrochelatase
chr13_-_38172863 0.130 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN





periostin, osteoblast specific factor





chr8_-_6420565 0.130 ENST00000338312.6
ANGPT2
angiopoietin 2
chr16_+_28763108 0.130 ENST00000357796.3
ENST00000550983.1
NPIPB9

nuclear pore complex interacting protein family, member B9

chr12_-_75603482 0.127 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr12_+_8309630 0.126 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr4_+_158141899 0.126 ENST00000264426.9
ENST00000506284.1
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr12_-_75603643 0.124 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr14_+_64932210 0.123 ENST00000394718.4
AKAP5
A kinase (PRKA) anchor protein 5
chr6_+_159084188 0.123 ENST00000367081.3
SYTL3
synaptotagmin-like 3
chr17_-_7387524 0.123 ENST00000311403.4
ZBTB4
zinc finger and BTB domain containing 4
chr4_-_74486347 0.122 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr14_+_22948510 0.122 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr3_-_46068969 0.122 ENST00000542109.1
ENST00000395946.2
XCR1

chemokine (C motif) receptor 1

chr18_-_21852143 0.121 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr6_-_89927151 0.120 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_-_157015162 0.118 ENST00000368194.3
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr12_-_127256858 0.117 ENST00000542248.1
ENST00000540684.1
LINC00944

long intergenic non-protein coding RNA 944

chr3_+_238273 0.117 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr17_+_7792101 0.116 ENST00000358181.4
ENST00000330494.7
CHD3

chromodomain helicase DNA binding protein 3

chr15_+_85147127 0.116 ENST00000541040.1
ENST00000538076.1
ENST00000485222.2
ZSCAN2


zinc finger and SCAN domain containing 2


chr14_-_60337684 0.114 ENST00000267484.5
RTN1
reticulon 1
chr12_+_26348429 0.114 ENST00000242729.2
SSPN
sarcospan
chrX_+_45364633 0.113 ENST00000435394.1
ENST00000609127.1
RP11-245M24.1

RP11-245M24.1

chr8_-_17942432 0.113 ENST00000381733.4
ENST00000314146.10
ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

chr16_+_75033210 0.112 ENST00000566250.1
ENST00000567962.1
ZNRF1

zinc and ring finger 1, E3 ubiquitin protein ligase

chr14_-_106610852 0.111 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr14_-_106668095 0.111 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr4_-_74486217 0.111 ENST00000335049.5
ENST00000307439.5
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr6_+_33388013 0.111 ENST00000449372.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr6_-_10412600 0.110 ENST00000379608.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_+_39382900 0.109 ENST00000377721.3
ENST00000455970.2
KRTAP9-2

keratin associated protein 9-2

chr7_+_1126437 0.107 ENST00000413368.1
ENST00000397092.1
GPER1

G protein-coupled estrogen receptor 1

chr10_-_116444371 0.106 ENST00000533213.2
ENST00000369252.4
ABLIM1

actin binding LIM protein 1

chr4_-_168155417 0.106 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr9_-_139361503 0.106 ENST00000453963.1
SEC16A
SEC16 homolog A (S. cerevisiae)
chr3_-_46069223 0.105 ENST00000309285.3
XCR1
chemokine (C motif) receptor 1
chr1_-_48866517 0.105 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr8_-_145754428 0.104 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82


chromosome 8 open reading frame 82


chr4_+_158141806 0.104 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr2_+_220462560 0.104 ENST00000456909.1
ENST00000295641.10
STK11IP

serine/threonine kinase 11 interacting protein

chr2_-_202562716 0.103 ENST00000428900.2
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chrX_-_15619076 0.103 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr20_+_4702548 0.102 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr21_-_36421535 0.101 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1


runt-related transcription factor 1


chr5_+_43603229 0.100 ENST00000344920.4
ENST00000512996.2
NNT

nicotinamide nucleotide transhydrogenase

chr5_+_92919043 0.099 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_-_75912508 0.098 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr5_+_131993856 0.097 ENST00000304506.3
IL13
interleukin 13
chr2_-_101767715 0.097 ENST00000376840.4
ENST00000409318.1
TBC1D8

TBC1 domain family, member 8 (with GRAM domain)

chr9_-_6015607 0.096 ENST00000259569.5
RANBP6
RAN binding protein 6
chr21_-_36421626 0.095 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr13_+_97874574 0.095 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
MBNL2


muscleblind-like splicing regulator 2


chr16_+_81272287 0.095 ENST00000425577.2
ENST00000564552.1
BCMO1

beta-carotene 15,15'-monooxygenase 1

chrX_+_135251783 0.095 ENST00000394153.2
FHL1
four and a half LIM domains 1
chr4_-_168155730 0.094 ENST00000502330.1
ENST00000357154.3
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr9_-_36401155 0.094 ENST00000377885.2
RNF38
ring finger protein 38
chrX_+_135230712 0.094 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr1_-_8877692 0.093 ENST00000400908.2
RERE
arginine-glutamic acid dipeptide (RE) repeats

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 0.5 GO:0001172 transcription, RNA-templated(GO:0001172)
0.1 0.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 0.2 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.2 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.2 GO:1904170 NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.1 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.2 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.5 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0070541 response to platinum ion(GO:0070541)
0.0 0.3 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.4 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:0060648 mammary gland bud morphogenesis(GO:0060648) regulation of determination of dorsal identity(GO:2000015)
0.0 0.3 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.1 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.0 0.1 GO:1990523 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.1 GO:1905167 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.1 GO:0061526 acetylcholine secretion(GO:0061526)
0.0 0.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:0090034 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.0 0.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.1 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.1 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 1.7 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.2 GO:0032310 prostaglandin secretion(GO:0032310)
0.0 0.4 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.7 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.0 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.1 GO:0035004 phosphatidylinositol 3-kinase activity(GO:0035004) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.2 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.1 1.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0005503 all-trans retinal binding(GO:0005503)
0.0 0.2 GO:0030305 heparanase activity(GO:0030305)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0016160 amylase activity(GO:0016160)
0.0 0.2 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.2 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.3 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.2 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 1.2 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation