Motif ID: IKZF2

Z-value: 0.715


Transcription factors associated with IKZF2:

Gene SymbolEntrez IDGene Name
IKZF2 ENSG00000030419.12 IKZF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v2_chr2_-_214016314_214016343-0.067.6e-01Click!


Activity profile for motif IKZF2.

activity profile for motif IKZF2


Sorted Z-values histogram for motif IKZF2

Sorted Z-values for motif IKZF2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_92219919 0.882 ENST00000252506.6
ENST00000375769.1
 GADD45G

growth arrest and DNA-damage-inducible, gamma

chr20_+_58179582 0.865 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr12_+_26348582 0.554 ENST00000535504.1
 SSPN
sarcospan
chr6_+_32605195 0.537 ENST00000374949.2
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_216257849 0.495 ENST00000456923.1
 FN1
fibronectin 1
chr14_+_32546145 0.462 ENST00000556611.1
ENST00000539826.2
 ARHGAP5

Rho GTPase activating protein 5

chr6_+_32605134 0.453 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
 HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr1_-_157014865 0.427 ENST00000361409.2
 ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr4_+_86525299 0.403 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr17_+_26369865 0.393 ENST00000582037.1
 NLK
nemo-like kinase
chr15_-_90358048 0.382 ENST00000300060.6
ENST00000560137.1
 ANPEP

alanyl (membrane) aminopeptidase

chr22_+_40297105 0.372 ENST00000540310.1
 GRAP2
GRB2-related adaptor protein 2
chr12_-_52867569 0.370 ENST00000252250.6
 KRT6C
keratin 6C
chr12_-_81763127 0.369 ENST00000541017.1
 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_-_161337662 0.362 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr12_-_81763184 0.360 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
 PPFIA2


protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


chr9_-_3469181 0.345 ENST00000366116.2
 AL365202.1
Uncharacterized protein
chrX_-_15683147 0.339 ENST00000380342.3
 TMEM27
transmembrane protein 27
chr22_+_40297079 0.329 ENST00000344138.4
ENST00000543252.1
 GRAP2

GRB2-related adaptor protein 2

chr1_+_111889212 0.328 ENST00000369737.4
 PIFO
primary cilia formation

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.7 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 0.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 0.5 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.5 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.4 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.4 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.1 0.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.3 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.1 1.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.5 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.2 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0005503 all-trans retinal binding(GO:0005503)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.0 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12