Motif ID: INSM1

Z-value: 0.761


Transcription factors associated with INSM1:

Gene SymbolEntrez IDGene Name
INSM1 ENSG00000173404.3 INSM1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
INSM1hg19_v2_chr20_+_20348740_203487650.491.4e-02Click!


Activity profile for motif INSM1.

activity profile for motif INSM1


Sorted Z-values histogram for motif INSM1

Sorted Z-values for motif INSM1



Network of associatons between targets according to the STRING database.



First level regulatory network of INSM1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_72375167 2.565 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr15_+_45722727 2.464 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
C15orf48


chromosome 15 open reading frame 48


chr22_+_38071615 2.392 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr12_-_58131931 1.905 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_+_85996471 1.268 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_+_70760056 1.245 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr17_+_42081914 1.215 ENST00000293404.3
ENST00000589767.1
NAGS

N-acetylglutamate synthase

chr6_-_41863098 1.187 ENST00000373006.1
USP49
ubiquitin specific peptidase 49
chr12_-_6960407 1.140 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
CDCA3



cell division cycle associated 3



chr1_+_153750622 1.116 ENST00000532853.1
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr7_+_86274145 1.035 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3


glutamate receptor, metabotropic 3


chr9_+_116263639 0.983 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr9_+_116263778 0.979 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr3_+_50192537 0.911 ENST00000002829.3
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr3_+_50192499 0.901 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_76776957 0.830 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr6_+_31126291 0.806 ENST00000376257.3
ENST00000376255.4
TCF19

transcription factor 19

chr11_+_124932955 0.749 ENST00000403796.2
SLC37A2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr11_+_124932986 0.738 ENST00000407458.1
ENST00000298280.5
SLC37A2

solute carrier family 37 (glucose-6-phosphate transporter), member 2

chr14_+_65879668 0.733 ENST00000553924.1
ENST00000358307.2
ENST00000557338.1
ENST00000554610.1
FUT8



fucosyltransferase 8 (alpha (1,6) fucosyltransferase)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 2.9 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.5 2.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 2.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 2.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 1.8 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 1.8 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 1.8 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.3 1.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 1.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 1.4 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.4 1.2 GO:0036071 N-glycan fucosylation(GO:0036071)
0.3 1.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 0.8 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.8 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.7 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) positive regulation of axon regeneration(GO:0048680) action potential propagation(GO:0098870)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.4 GO:0070435 Shc-EGFR complex(GO:0070435)
0.0 1.4 GO:0015030 Cajal body(GO:0015030)
0.1 0.9 GO:0032039 integrator complex(GO:0032039)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.6 GO:0045160 myosin I complex(GO:0045160)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0019034 viral replication complex(GO:0019034)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 GO:0045499 chemorepellent activity(GO:0045499)
0.6 2.9 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.6 2.4 GO:0030395 lactose binding(GO:0030395)
0.3 2.2 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.3 1.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.5 1.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 1.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 1.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 1.2 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.2 1.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand