Motif ID: IRF2_STAT2_IRF8_IRF1

Z-value: 2.497

Transcription factors associated with IRF2_STAT2_IRF8_IRF1:

Gene SymbolEntrez IDGene Name
IRF1 ENSG00000125347.9 IRF1
IRF2 ENSG00000168310.6 IRF2
IRF8 ENSG00000140968.6 IRF8
STAT2 ENSG00000170581.9 STAT2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF1hg19_v2_chr5_-_131826457_1318265140.898.7e-09Click!
STAT2hg19_v2_chr12_-_56753858_567539300.529.3e-03Click!
IRF8hg19_v2_chr16_+_85942594_859426350.174.2e-01Click!
IRF2hg19_v2_chr4_-_185395672_1853957340.154.9e-01Click!


Activity profile for motif IRF2_STAT2_IRF8_IRF1.

activity profile for motif IRF2_STAT2_IRF8_IRF1


Sorted Z-values histogram for motif IRF2_STAT2_IRF8_IRF1

Sorted Z-values for motif IRF2_STAT2_IRF8_IRF1



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_39770803 18.303 ENST00000518237.1
 IDO1
indoleamine 2,3-dioxygenase 1
chr6_+_32821924 14.496 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr1_-_207119738 13.992 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr2_-_7005785 12.489 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
 CMPK2


cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial


chr21_+_42733870 11.923 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr1_+_79115503 10.507 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr6_-_29527702 9.856 ENST00000377050.4
 UBD
ubiquitin D
chr1_+_79086088 9.119 ENST00000370751.5
ENST00000342282.3
 IFI44L

interferon-induced protein 44-like

chr9_-_32526184 9.106 ENST00000545044.1
ENST00000379868.1
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr4_-_169239921 8.685 ENST00000514995.1
ENST00000393743.3
 DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr19_-_17516449 8.614 ENST00000252593.6
 BST2
bone marrow stromal cell antigen 2
chr1_-_27998689 8.500 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
 IFI6


interferon, alpha-inducible protein 6


chr10_+_91152303 8.476 ENST00000371804.3
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr17_+_6659153 7.714 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1



XIAP associated factor 1



chr1_+_948803 7.316 ENST00000379389.4
 ISG15
ISG15 ubiquitin-like modifier
chr9_-_32526299 6.967 ENST00000379882.1
ENST00000379883.2
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr3_+_187086120 6.621 ENST00000259030.2
 RTP4
receptor (chemosensory) transporter protein 4
chr10_+_91087651 6.535 ENST00000371818.4
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_40264692 6.404 ENST00000591220.1
ENST00000251642.3
 DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

chr7_-_122526799 6.183 ENST00000334010.7
ENST00000313070.7
 CADPS2

Ca++-dependent secretion activator 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 31.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
1.8 19.3 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
4.6 18.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
4.6 18.3 GO:0036269 swimming behavior(GO:0036269)
1.2 16.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
1.5 15.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.8 15.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.4 14.4 GO:0035456 response to interferon-beta(GO:0035456)
2.8 14.0 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
4.2 12.5 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
1.4 10.8 GO:1990504 dense core granule exocytosis(GO:1990504)
2.0 9.9 GO:0070842 aggresome assembly(GO:0070842)
0.8 9.9 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.4 9.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 9.2 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.2 9.0 GO:0032608 interferon-beta production(GO:0032608)
2.9 8.6 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
2.8 8.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 8.2 GO:0007286 spermatid development(GO:0007286)
0.7 8.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 40.5 GO:0005739 mitochondrion(GO:0005739)
3.0 27.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 25.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 17.0 GO:0032587 ruffle membrane(GO:0032587)
2.5 15.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 10.5 GO:0000139 Golgi membrane(GO:0000139)
0.2 10.1 GO:0005643 nuclear pore(GO:0005643)
0.1 9.2 GO:0016235 aggresome(GO:0016235)
0.1 9.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 8.9 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.1 7.3 GO:0005811 lipid particle(GO:0005811)
0.0 6.9 GO:0031965 nuclear membrane(GO:0031965)
0.1 5.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 4.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.4 4.0 GO:0030870 Mre11 complex(GO:0030870)
0.2 4.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 4.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 3.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 3.7 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 3.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 43.3 GO:0005525 GTP binding(GO:0005525)
0.3 37.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.9 27.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
6.1 18.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
1.8 14.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
3.1 12.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.5 9.9 GO:0070628 proteasome binding(GO:0070628)
0.0 9.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 8.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.1 7.6 GO:0046979 TAP2 binding(GO:0046979)
0.6 7.3 GO:0031386 protein tag(GO:0031386)
0.0 7.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.6 6.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 6.3 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
1.2 6.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
1.2 5.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 5.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 5.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 5.2 GO:0070330 aromatase activity(GO:0070330)
0.1 4.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 6.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 6.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 2.8 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 2.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.3 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 84.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 28.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
1.0 20.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.9 17.8 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.3 12.9 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.6 8.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.5 7.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 6.0 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 4.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.6 2.5 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 2.3 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 2.0 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.8 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression