Motif ID: IRF2_STAT2_IRF8_IRF1
Z-value: 2.497
Transcription factors associated with IRF2_STAT2_IRF8_IRF1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF1 | ENSG00000125347.9 | IRF1 |
| IRF2 | ENSG00000168310.6 | IRF2 |
| IRF8 | ENSG00000140968.6 | IRF8 |
| STAT2 | ENSG00000170581.9 | STAT2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.89 | 8.7e-09 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.52 | 9.3e-03 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | 0.17 | 4.2e-01 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.15 | 4.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 18.3 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 4.6 | 18.3 | GO:0036269 | swimming behavior(GO:0036269) |
| 4.2 | 12.5 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 3.8 | 15.3 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 2.9 | 8.6 | GO:1901253 | negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253) |
| 2.8 | 8.5 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 2.8 | 14.0 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 2.0 | 9.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 1.8 | 19.3 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.5 | 15.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.5 | 7.4 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 1.5 | 5.8 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 1.4 | 10.8 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 1.3 | 4.0 | GO:0050823 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.2 | 16.1 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.2 | 3.6 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
| 1.1 | 3.3 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 1.1 | 3.2 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 1.0 | 1.0 | GO:1903989 | positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 0.9 | 4.6 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 0.9 | 3.4 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.8 | 9.9 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.8 | 3.1 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.7 | 8.1 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.7 | 2.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.7 | 2.6 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.6 | 1.3 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.6 | 5.1 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.6 | 2.4 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.6 | 4.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.6 | 1.7 | GO:0014057 | positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) |
| 0.5 | 1.5 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.5 | 4.5 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.4 | 1.8 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.4 | 1.3 | GO:0034239 | macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) |
| 0.4 | 1.3 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.4 | 1.8 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.4 | 1.3 | GO:0045608 | negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.4 | 9.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.4 | 14.4 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.4 | 2.4 | GO:2000834 | androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) |
| 0.4 | 2.0 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.4 | 2.0 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.4 | 2.0 | GO:1904977 | lymphatic endothelial cell migration(GO:1904977) |
| 0.4 | 1.1 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.4 | 2.1 | GO:0030421 | defecation(GO:0030421) |
| 0.3 | 1.4 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.3 | 2.3 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 1.0 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
| 0.3 | 1.0 | GO:0042495 | central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
| 0.3 | 9.2 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.3 | 31.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.3 | 0.6 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.3 | 2.3 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.3 | 0.8 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.3 | 1.4 | GO:0031296 | B cell costimulation(GO:0031296) |
| 0.3 | 6.0 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.3 | 1.3 | GO:0019075 | virus maturation(GO:0019075) |
| 0.3 | 0.5 | GO:0021794 | thalamus development(GO:0021794) |
| 0.3 | 0.8 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.3 | 3.6 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.3 | 2.0 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.2 | 0.7 | GO:0070541 | response to platinum ion(GO:0070541) |
| 0.2 | 1.5 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.2 | 1.7 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 2.1 | GO:2001023 | regulation of response to drug(GO:2001023) |
| 0.2 | 1.1 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.2 | 0.6 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) negative regulation of alkaline phosphatase activity(GO:0010693) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.2 | 0.9 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.2 | 1.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 0.8 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.2 | 3.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 1.2 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.2 | 0.8 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.2 | 1.0 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
| 0.2 | 2.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 0.4 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 0.2 | 7.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 0.7 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.2 | 2.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.2 | 1.1 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.2 | 0.7 | GO:0007402 | ganglion mother cell fate determination(GO:0007402) |
| 0.2 | 0.7 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.2 | 0.9 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.2 | 0.7 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.2 | 0.5 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 0.2 | 4.3 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 0.2 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
| 0.2 | 3.2 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.2 | 9.0 | GO:0032608 | interferon-beta production(GO:0032608) |
| 0.2 | 0.5 | GO:0015993 | L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.2 | 0.5 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.2 | 0.9 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.2 | 0.6 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.1 | 0.9 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 0.4 | GO:1905246 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.1 | 1.8 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.1 | 1.9 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.1 | 0.8 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
| 0.1 | 0.8 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.1 | 0.3 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 0.8 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.1 | 0.3 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.1 | 0.6 | GO:0034128 | detection of lipopolysaccharide(GO:0032497) negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.1 | 0.9 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.4 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 6.1 | GO:0006536 | glutamate metabolic process(GO:0006536) |
| 0.1 | 1.0 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 3.0 | GO:1900116 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.1 | 1.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 1.8 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.8 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.1 | 1.5 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.3 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.1 | 0.3 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.1 | 0.4 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 0.5 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
| 0.1 | 2.0 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 0.4 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.1 | 0.4 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.1 | 0.4 | GO:0039506 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.1 | 0.2 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.1 | 0.6 | GO:0003014 | renal system process(GO:0003014) |
| 0.1 | 0.6 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.1 | 0.5 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 0.1 | 1.1 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 0.5 | GO:0022604 | regulation of cell morphogenesis(GO:0022604) |
| 0.1 | 0.4 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.1 | 1.1 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.1 | 0.3 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 0.1 | 1.4 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 0.3 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.1 | 3.1 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.1 | 0.2 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.1 | 0.2 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 0.2 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 0.6 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.1 | 0.2 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.1 | 0.5 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 0.5 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 1.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 2.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 4.1 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.1 | 2.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 0.3 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.1 | 0.2 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.1 | 0.6 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 0.3 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.1 | 0.4 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 1.6 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.3 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.1 | 0.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 0.5 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.9 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.6 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.1 | 0.3 | GO:1904764 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.1 | 0.5 | GO:0021678 | third ventricle development(GO:0021678) |
| 0.1 | 1.9 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 0.6 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 0.3 | GO:0045348 | positive regulation of MHC class II biosynthetic process(GO:0045348) |
| 0.1 | 0.2 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.1 | 0.2 | GO:0046968 | peptide antigen transport(GO:0046968) |
| 0.1 | 0.3 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.1 | 1.5 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 0.5 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.1 | 0.2 | GO:0032242 | regulation of nucleoside transport(GO:0032242) positive regulation of necroptotic process(GO:0060545) |
| 0.1 | 0.3 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.1 | 0.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.8 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.1 | 0.5 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.1 | 2.0 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.1 | 0.9 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.2 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.1 | 0.6 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.1 | 0.3 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.1 | 0.4 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.1 | 0.4 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.1 | 0.2 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 1.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 0.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.0 | 0.5 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.0 | 8.2 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.9 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 0.0 | 0.4 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.5 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 1.9 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.0 | 1.2 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 1.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 1.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 2.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.2 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) regulation of ovarian follicle development(GO:2000354) |
| 0.0 | 0.1 | GO:0046005 | positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005) |
| 0.0 | 0.2 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.0 | 0.8 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.1 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.0 | 0.7 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.0 | 1.1 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 1.9 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.0 | 0.5 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.4 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.0 | 0.6 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.0 | 0.1 | GO:0098907 | protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907) |
| 0.0 | 0.2 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.8 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.0 | 0.2 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.0 | 0.6 | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process(GO:0070525) |
| 0.0 | 0.2 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.0 | 0.9 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.0 | 0.6 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.7 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 0.4 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.1 | GO:0051140 | regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) |
| 0.0 | 0.7 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 0.6 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.0 | 0.2 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 0.1 | GO:0060926 | cardiac pacemaker cell development(GO:0060926) sinoatrial node cell development(GO:0060931) |
| 0.0 | 0.2 | GO:1900165 | negative regulation of interleukin-6 secretion(GO:1900165) |
| 0.0 | 0.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.0 | 0.2 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.2 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.0 | 0.2 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.3 | GO:2000121 | regulation of removal of superoxide radicals(GO:2000121) |
| 0.0 | 1.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.1 | GO:2000809 | positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.0 | 1.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 1.2 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.6 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.3 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 0.1 | GO:0085020 | protein K6-linked ubiquitination(GO:0085020) regulation of kinetochore assembly(GO:0090234) |
| 0.0 | 0.7 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.0 | 0.1 | GO:0050955 | thermoception(GO:0050955) |
| 0.0 | 0.4 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.4 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 0.2 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.0 | 0.3 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
| 0.0 | 0.4 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.3 | GO:0002775 | antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) |
| 0.0 | 0.1 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
| 0.0 | 0.1 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.0 | 0.2 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.0 | 0.4 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.4 | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) |
| 0.0 | 0.7 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 1.0 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 0.2 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.2 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 0.1 | GO:0045726 | positive regulation of integrin biosynthetic process(GO:0045726) |
| 0.0 | 0.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.4 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.2 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.0 | 0.5 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:0036508 | protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.0 | 0.2 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.1 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 0.2 | GO:0002758 | innate immune response-activating signal transduction(GO:0002758) |
| 0.0 | 0.2 | GO:0071351 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
| 0.0 | 0.1 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.0 | 0.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.1 | GO:1903756 | regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.0 | 0.7 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.2 | GO:0015747 | urate transport(GO:0015747) |
| 0.0 | 0.6 | GO:0007601 | visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953) |
| 0.0 | 0.2 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway(GO:0035791) |
| 0.0 | 0.2 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.0 | 0.4 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.0 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.0 | 3.1 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.2 | GO:0010523 | negative regulation of calcium ion transport into cytosol(GO:0010523) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.0 | 0.2 | GO:0035810 | positive regulation of urine volume(GO:0035810) |
| 0.0 | 0.2 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 0.0 | 0.1 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.0 | 0.3 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
| 0.0 | 0.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.2 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.6 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 0.7 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.1 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.1 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.0 | 0.3 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
| 0.0 | 0.4 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.0 | 0.9 | GO:0051603 | proteolysis involved in cellular protein catabolic process(GO:0051603) |
| 0.0 | 0.0 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.6 | GO:0003341 | cilium movement(GO:0003341) |
| 0.0 | 0.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.8 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.7 | GO:0009988 | cell-cell recognition(GO:0009988) |
| 0.0 | 0.0 | GO:0021612 | rhombomere 3 development(GO:0021569) facial nerve structural organization(GO:0021612) |
| 0.0 | 0.6 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 0.8 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 0.1 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.0 | 1.6 | GO:0007586 | digestion(GO:0007586) |
| 0.0 | 0.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 27.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 2.5 | 15.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.7 | 4.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.7 | 3.4 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.5 | 3.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.5 | 1.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.5 | 3.5 | GO:0042825 | TAP complex(GO:0042825) |
| 0.4 | 4.0 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.4 | 1.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.3 | 3.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.3 | 1.0 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.3 | 0.8 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.3 | 1.1 | GO:0031213 | RSF complex(GO:0031213) |
| 0.3 | 25.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 0.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.2 | 3.7 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.2 | 4.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.2 | 0.6 | GO:0001534 | radial spoke(GO:0001534) |
| 0.2 | 2.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 2.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 1.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 10.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 9.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 0.3 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 0.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 2.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.9 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 1.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 17.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 8.9 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 1.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.4 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.9 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 0.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.6 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.1 | 1.4 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 0.8 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 7.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 9.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.6 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 1.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 2.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 5.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 3.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.2 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 0.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.2 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.2 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 1.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.7 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 1.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.1 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.3 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.0 | 0.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.3 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.0 | 0.1 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 0.0 | 0.6 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 2.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.4 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.1 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.7 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 2.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.0 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.2 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 3.5 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.4 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.4 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.3 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 0.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.1 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.0 | 1.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 6.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 1.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.0 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 0.5 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 40.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.2 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.2 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.1 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 0.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.1 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 0.3 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 10.5 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.3 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 0.1 | GO:0000815 | ESCRT III complex(GO:0000815) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 18.3 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 3.1 | 12.5 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 1.8 | 14.1 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 1.6 | 6.4 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 1.2 | 6.1 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 1.2 | 5.8 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 1.1 | 3.4 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 1.1 | 7.6 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.9 | 3.6 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.9 | 27.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.8 | 4.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.6 | 3.8 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.6 | 7.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.6 | 2.4 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.6 | 2.3 | GO:0016160 | amylase activity(GO:0016160) |
| 0.5 | 4.3 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.5 | 2.8 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.5 | 9.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.4 | 3.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.4 | 2.4 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.4 | 1.6 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.4 | 3.6 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.4 | 2.4 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.4 | 3.1 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.4 | 1.8 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.4 | 1.8 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.4 | 1.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.3 | 1.7 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.3 | 1.3 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.3 | 1.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.3 | 37.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.3 | 4.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.3 | 8.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.3 | 0.8 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 1.1 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.3 | 1.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.3 | 1.0 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 1.7 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.2 | 3.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 5.2 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.2 | 5.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.2 | 3.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 1.0 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.2 | 1.0 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.2 | 0.9 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.2 | 0.7 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.2 | 0.9 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.2 | 1.6 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.2 | 1.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.2 | 0.5 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.2 | 2.3 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.2 | 0.6 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 2.1 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.2 | 0.5 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.2 | 1.4 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 0.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 2.0 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.2 | 0.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 2.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.1 | 0.6 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.1 | 0.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.1 | 0.4 | GO:0051499 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.1 | 0.9 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 1.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.2 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.1 | 0.9 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 2.5 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.1 | 3.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 0.3 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.1 | 0.6 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 0.7 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.1 | 1.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.2 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 0.1 | 0.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.5 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 0.9 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 0.6 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.1 | 4.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.3 | GO:0102008 | cytosolic dipeptidase activity(GO:0102008) |
| 0.1 | 0.4 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 3.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 3.0 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.1 | 4.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.1 | 43.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 0.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.9 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 1.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.2 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 0.1 | 0.7 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 0.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.1 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.1 | 1.2 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 2.0 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.8 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 0.4 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.1 | 0.6 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 5.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 1.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.2 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.1 | 4.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.9 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 1.1 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 1.9 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.6 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 0.1 | 0.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 2.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.0 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.0 | 0.2 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.0 | 0.6 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.0 | 0.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.0 | 0.9 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 1.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.0 | 0.3 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.8 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.4 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.7 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.5 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.1 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.0 | 0.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.2 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.1 | GO:0016608 | growth hormone-releasing hormone activity(GO:0016608) |
| 0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 2.6 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.2 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.9 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 1.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 4.0 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 9.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.3 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.0 | 0.7 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.4 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.1 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.0 | 0.3 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.0 | 0.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.0 | 0.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.0 | 0.1 | GO:0001224 | RNA polymerase II transcription cofactor binding(GO:0001224) |
| 0.0 | 2.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.5 | GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114) |
| 0.0 | 1.6 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 0.5 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.1 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 3.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.7 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 0.2 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.5 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 2.0 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.3 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.9 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.1 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.4 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.0 | 1.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.5 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.0 | 0.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 6.3 | GO:0001159 | core promoter proximal region DNA binding(GO:0001159) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 4.2 | GO:0016746 | transferase activity, transferring acyl groups(GO:0016746) |
| 0.0 | 0.2 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.0 | 0.5 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 1.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.1 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 0.1 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.0 | 0.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 1.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.1 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.0 | 0.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.2 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.4 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 7.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 1.1 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.1 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.2 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 5.8 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.5 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 2.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 6.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 1.9 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 7.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.8 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.3 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.2 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.9 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 1.8 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.9 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 2.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.7 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 1.4 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.3 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 2.3 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.0 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.0 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.0 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.0 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.2 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.7 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.2 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.4 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.4 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.4 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.2 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.3 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 20.1 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.9 | 17.8 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.9 | 84.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 2.5 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.6 | 8.3 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 7.4 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.4 | 28.1 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 12.9 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 2.3 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.2 | 6.0 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 2.1 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.3 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 0.8 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 0.8 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 2.8 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.0 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 0.6 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 4.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.3 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 1.2 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.0 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.0 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 0.8 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.6 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.8 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.2 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.8 | REACTOME_PERK_REGULATED_GENE_EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.2 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.7 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.0 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 1.6 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.5 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 2.0 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.7 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.2 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.0 | 1.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.4 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.8 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.4 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 1.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.2 | REACTOME_SPHINGOLIPID_METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.0 | 0.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.4 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 1.0 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 2.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 1.2 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 3.8 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.6 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.2 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.8 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.4 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.2 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.9 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.2 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.5 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
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