Motif ID: IRF3
Z-value: 1.278
Transcription factors associated with IRF3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF3 | ENSG00000126456.11 | IRF3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50169064_50169132 | -0.14 | 5.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.4 | 5.6 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.2 | 3.5 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 1.2 | 4.6 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 1.1 | 3.2 | GO:1901253 | negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253) |
| 1.0 | 3.1 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 0.9 | 3.8 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.7 | 5.6 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.7 | 3.4 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 0.6 | 1.9 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.5 | 6.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.5 | 2.9 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.5 | 4.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.4 | 1.2 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 0.3 | 0.3 | GO:1903989 | positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 0.3 | 7.4 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.3 | 0.8 | GO:2001190 | natural killer cell tolerance induction(GO:0002519) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.3 | 0.8 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.2 | 2.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 0.9 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.2 | 0.7 | GO:0019056 | modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
| 0.2 | 1.6 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.2 | 3.0 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.2 | 0.7 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.1 | 3.4 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.1 | 1.0 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.4 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.1 | 0.4 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 0.1 | 7.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 1.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 2.6 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 1.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.5 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.1 | 0.1 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.1 | 0.3 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 2.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 2.9 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 3.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 2.5 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 1.0 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.4 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 1.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.1 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.0 | 2.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 2.6 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 0.0 | 0.8 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.7 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.0 | 0.6 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.5 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 1.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.6 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.7 | GO:0048714 | positive regulation of oligodendrocyte differentiation(GO:0048714) |
| 0.0 | 1.5 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.0 | 0.4 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 0.2 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.3 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.2 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 1.9 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.0 | 1.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 0.3 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.8 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.6 | 5.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.4 | 2.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 0.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 2.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 3.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.6 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.1 | 0.4 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 1.6 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 0.4 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 2.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 0.3 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.0 | 0.4 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 2.7 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 2.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 4.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 3.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 7.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 3.4 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 3.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.8 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.1 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 1.0 | 2.9 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.9 | 4.6 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.5 | 7.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.3 | 2.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.3 | 1.1 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.3 | 1.1 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.2 | 0.7 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.2 | 2.7 | GO:0031386 | protein tag(GO:0031386) |
| 0.2 | 1.8 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.2 | 5.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 0.8 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.1 | 0.5 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.1 | 0.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 3.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.4 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.1 | 0.6 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.1 | 10.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 1.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 1.1 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 0.8 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 0.5 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.1 | 0.4 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.1 | 2.5 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.1 | 0.7 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.1 | 0.7 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 1.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 3.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.3 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 0.4 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.0 | 0.2 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.7 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 2.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.3 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.9 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 1.4 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.0 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 4.4 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.4 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 5.6 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.2 | 3.4 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 3.8 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 14.4 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 7.5 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 0.3 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 4.8 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 1.4 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 2.9 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.0 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.5 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 2.4 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.6 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.5 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 1.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.1 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.7 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.1 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.3 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
