Motif ID: IRF6_IRF4_IRF5

Z-value: 0.868

Transcription factors associated with IRF6_IRF4_IRF5:

Gene SymbolEntrez IDGene Name
IRF4 ENSG00000137265.10 IRF4
IRF5 ENSG00000128604.14 IRF5
IRF6 ENSG00000117595.6 IRF6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979375_209979389-0.491.5e-02Click!
IRF5hg19_v2_chr7_+_128577972_128578047-0.272.1e-01Click!
IRF4hg19_v2_chr6_+_391739_391759-0.019.5e-01Click!


Activity profile for motif IRF6_IRF4_IRF5.

activity profile for motif IRF6_IRF4_IRF5


Sorted Z-values histogram for motif IRF6_IRF4_IRF5

Sorted Z-values for motif IRF6_IRF4_IRF5



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_32526299 4.379 ENST00000379882.1
ENST00000379883.2
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr9_-_32526184 4.255 ENST00000545044.1
ENST00000379868.1
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr15_-_45670924 2.745 ENST00000396659.3
 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr21_+_42733870 1.867 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr2_-_7005785 1.701 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
 CMPK2


cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial


chr5_-_35938674 1.534 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr17_+_6659153 1.413 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1



XIAP associated factor 1



chr11_-_57335280 1.400 ENST00000287156.4
 UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr21_+_42792442 1.390 ENST00000398600.2
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_-_207119738 1.373 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr21_+_42798094 1.171 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
 MX1


myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)


chr19_-_3029011 1.125 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
 TLE2



transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)



chr1_+_78769549 1.065 ENST00000370758.1
 PTGFR
prostaglandin F receptor (FP)
chr8_+_8559406 1.052 ENST00000519106.1
 CLDN23
claudin 23
chr14_-_61190754 1.032 ENST00000216513.4
 SIX4
SIX homeobox 4
chr11_-_86383650 0.984 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
 ME3



malic enzyme 3, NADP(+)-dependent, mitochondrial



chr17_+_18380051 0.969 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
 LGALS9C





lectin, galactoside-binding, soluble, 9C





chr6_+_32605195 0.955 ENST00000374949.2
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_+_113344582 0.937 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
 OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr17_-_20370847 0.931 ENST00000423676.3
ENST00000324290.5
 LGALS9B

lectin, galactoside-binding, soluble, 9B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.4 4.4 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.3 3.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 2.7 GO:0006600 creatine metabolic process(GO:0006600)
0.2 2.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 2.1 GO:0035456 response to interferon-beta(GO:0035456)
0.6 1.7 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 1.5 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 1.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.3 1.4 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 1.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 1.1 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 1.1 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.3 1.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.9 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 0.8 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.1 0.8 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 0.7 GO:2001190 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.9 GO:0005643 nuclear pore(GO:0005643)
0.1 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.4 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.8 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.8 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 0.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.3 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 4.8 GO:0003924 GTPase activity(GO:0003924)
0.2 3.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 2.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 1.5 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.4 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 1.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 0.8 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 0.7 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.7 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.5 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 7.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.9 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane