Motif ID: IRF9

Z-value: 0.967


Transcription factors associated with IRF9:

Gene SymbolEntrez IDGene Name
IRF9 ENSG00000213928.4 IRF9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.096.7e-01Click!


Activity profile for motif IRF9.

activity profile for motif IRF9


Sorted Z-values histogram for motif IRF9

Sorted Z-values for motif IRF9



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF9

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_+_42733870 6.166 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr1_+_79115503 3.556 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr2_-_7005785 3.550 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
 CMPK2


cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial


chr9_-_32526184 3.543 ENST00000545044.1
ENST00000379868.1
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr17_+_6659153 3.520 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1



XIAP associated factor 1



chr1_-_207119738 3.510 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr21_+_42798094 3.102 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
 MX1


myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)


chr1_-_150738261 2.921 ENST00000448301.2
ENST00000368985.3
 CTSS

cathepsin S

chr19_-_17516449 2.265 ENST00000252593.6
 BST2
bone marrow stromal cell antigen 2
chr8_+_39770803 2.252 ENST00000518237.1
 IDO1
indoleamine 2,3-dioxygenase 1
chr12_-_121477039 2.126 ENST00000257570.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr9_-_32526299 1.959 ENST00000379882.1
ENST00000379883.2
 DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr1_+_79086088 1.915 ENST00000370751.5
ENST00000342282.3
 IFI44L

interferon-induced protein 44-like

chr12_-_121476959 1.845 ENST00000339275.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr9_+_74764340 1.824 ENST00000376986.1
ENST00000358399.3
 GDA

guanine deaminase

chr11_-_86383157 1.655 ENST00000393324.3
 ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr1_+_948803 1.644 ENST00000379389.4
 ISG15
ISG15 ubiquitin-like modifier
chr6_-_46889694 1.557 ENST00000283296.7
ENST00000362015.4
ENST00000456426.2
 GPR116


G protein-coupled receptor 116


chr4_-_169239921 1.547 ENST00000514995.1
ENST00000393743.3
 DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr7_+_100728720 1.501 ENST00000306085.6
ENST00000412507.1
 TRIM56

tripartite motif containing 56


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.3 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.5 5.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 5.0 GO:0034340 response to type I interferon(GO:0034340)
1.2 3.6 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.7 3.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 3.5 GO:0035456 response to interferon-beta(GO:0035456)
0.6 3.1 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.3 3.0 GO:0072592 oxygen metabolic process(GO:0072592)
0.3 2.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.7 2.7 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 2.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.8 2.3 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.6 2.3 GO:0036269 swimming behavior(GO:0036269)
0.3 2.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 1.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 1.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 1.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.4 1.2 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.9 GO:0019805 quinolinate biosynthetic process(GO:0019805)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0005643 nuclear pore(GO:0005643)
0.0 5.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 5.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.4 2.9 GO:0036021 endolysosome lumen(GO:0036021)
0.4 2.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 9.3 GO:0008017 microtubule binding(GO:0008017)
0.9 3.6 GO:0009041 uridylate kinase activity(GO:0009041)
0.4 3.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.5 3.0 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3 2.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 2.9 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.7 GO:0019239 deaminase activity(GO:0019239)
0.8 2.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 2.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.6 GO:0031386 protein tag(GO:0031386)
0.0 1.4 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 1.2 GO:0034046 poly(G) binding(GO:0034046)
0.2 1.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 5.0 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4 4.5 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.2 3.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 2.4 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.8 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP