Motif ID: IRX2

Z-value: 0.431


Transcription factors associated with IRX2:

Gene SymbolEntrez IDGene Name
IRX2 ENSG00000170561.8 IRX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX2hg19_v2_chr5_-_2751762_2751784-0.096.9e-01Click!


Activity profile for motif IRX2.

activity profile for motif IRX2


Sorted Z-values histogram for motif IRX2

Sorted Z-values for motif IRX2



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 151 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_112565703 0.941 ENST00000488794.1
 CD200R1L
CD200 receptor 1-like
chr10_-_28270795 0.860 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr22_-_36013368 0.818 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
 MB



myoglobin



chr19_+_13134772 0.815 ENST00000587760.1
ENST00000585575.1
 NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr16_+_82068830 0.813 ENST00000199936.4
 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_+_88117683 0.798 ENST00000369562.4
 C6ORF165
UPF0704 protein C6orf165
chr13_+_35516390 0.737 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr14_+_75536280 0.706 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr5_+_36608422 0.664 ENST00000381918.3
 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_75536335 0.641 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C



zinc finger, C2HC-type containing 1C



chr4_-_70505358 0.623 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
 UGT2A2


UDP glucuronosyltransferase 2 family, polypeptide A2


chr10_+_134150835 0.596 ENST00000432555.2
 LRRC27
leucine rich repeat containing 27
chrX_-_117119243 0.590 ENST00000539496.1
ENST00000469946.1
 KLHL13

kelch-like family member 13

chr17_+_7761301 0.575 ENST00000332439.4
ENST00000570446.1
 CYB5D1

cytochrome b5 domain containing 1

chr17_+_7761013 0.553 ENST00000571846.1
 CYB5D1
cytochrome b5 domain containing 1
chr5_+_156696362 0.489 ENST00000377576.3
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr10_+_127661942 0.483 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
 FANK1


fibronectin type III and ankyrin repeat domains 1


chr3_-_151102529 0.481 ENST00000302632.3
 P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_-_38806404 0.448 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
 TLR1


toll-like receptor 1


chr11_+_103907308 0.448 ENST00000302259.3
 DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.2 0.8 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.7 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.4 GO:0042495 detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.4 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.4 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 0.3 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.2 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.2 0.5 GO:0030849 autosome(GO:0030849)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 0.8 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.3 GO:0004803 transposase activity(GO:0004803)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins